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A method for preparing conjugated linoleic acid isomer monomer using four-zone simulated moving bed system

A conjugated linoleic acid, four-zone simulation technology, applied in the field of linoleic acid monomer preparation, can solve the problems of difficulty in preparing high-purity CLA, inability to separate isomer monomers, etc., and achieve high-value utilization and improvement The effect of research and development

Active Publication Date: 2022-05-13
THE FIRST INST OF OCEANOGRAPHY SOA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At home and abroad, there is no research and development of single-component products of conjugated linoleic acid isomers. The conventional urea embedding method is difficult to prepare high-purity CLA, let alone separate its isomer monomers

Method used

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  • A method for preparing conjugated linoleic acid isomer monomer using four-zone simulated moving bed system
  • A method for preparing conjugated linoleic acid isomer monomer using four-zone simulated moving bed system
  • A method for preparing conjugated linoleic acid isomer monomer using four-zone simulated moving bed system

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Embodiment 1

[0032] 1. Raw materials

[0033] Provided by Qingdao Aohai Biological Co., Ltd., the total content of c9, t11-CLA and t10, c12-CLA is about 80%.

[0034] 2. Instrument

[0035] The instrument model is: CSEP9116 simulated moving bed, produced by German Nuoer Scientific Instrument Co., Ltd.

[0036] The four-zone simulated moving bed is used for separation, and two chromatographic columns (SB-CN) are arranged in each zone. The purification and separation process is shown in figure 1 .

[0037] The raw material (Feed) and eluent (Desorbent) flow into the simulated moving bed chromatography (SMBC) system continuously, c9, t11-CLA flows out from the extraction port (Extract), t10, c12-CLA flows out from the raffinate port (Raffinate).

[0038] 3. A method for preparing conjugated linoleic acid isomer monomers using a four-zone simulated moving bed system

[0039] 1. Ethyl esterification

[0040] The supplied raw material is acid, and for effective separation, ethyl esterificat...

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Abstract

The invention discloses a method for preparing conjugated linoleic acid isomer monomers using a four-zone simulated moving bed system. The method firstly esterifies conjugated linoleic acid ethyl, and then uses a four-zone simulated moving bed system to sequentially remove The second impurity and the first impurity, and finally the isomers were separated, and the effluents from the extraction port and the raffinate port were collected respectively, and rotary evaporated to dryness under reduced pressure to obtain two isomers of conjugated linoleic acid. The present invention utilizes high-efficiency simulated moving bed technology to separate and prepare CLA single isomers c9, t11-CLA and t10, c12-CLA with key activities of lowering blood sugar and lipids, and establishes two isomers of conjugated linoleic acid c9, t11‑CLA and t10,c12‑CLA separation technology system. The method of the present invention can produce the two isomers c9,t11-CLA and t10,c12-CLA of high-purity conjugated linoleic acid on a large scale, thereby realizing high-value utilization of CLA and further improving the research and development of conjugated linoleic acid products.

Description

technical field [0001] The invention belongs to the field of preparation of linoleic acid monomers, and in particular relates to a method for preparing conjugated linoleic acid isomer monomers by using a four-zone simulated moving bed system. Background technique [0002] Conjugated Linoleic Acid (CLA) is an isomer of linoleic acid, a natural active nutrient that is ubiquitous in humans and animals, and a natural regulator of lipid and carbohydrate metabolism. A large number of studies at home and abroad have proved that CLA has many important physiological functions such as anti-cancer, reducing body fat in humans and animals, increasing muscle, anti-atherosclerosis, anti-oxidation, improving immunity, increasing bone density, and regulating blood sugar. Conjugated linoleic acid has been widely used in the fields of health care products, functional foods and food additives. [0003] CLA is a mixture of octadecadienoic acid isomers containing conjugated double bonds. c9, t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C51/493C07C51/47C07C57/12
CPCC07C51/493C07C51/47C07B2200/09C07C57/12
Inventor 郑洲缪锦来刘丽娜曲长凤
Owner THE FIRST INST OF OCEANOGRAPHY SOA