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Medicinal preparation for repairing wounds, and preparation method thereof

A pharmaceutical preparation and wound technology, applied in the field of pharmaceutical preparations, can solve the problems of insignificant wound repair effect, low repair effect, obvious foreign body sensation of polymer materials, etc., achieve great clinical application value and social benefits, remarkable wound repair effect, The effect of preparing raw materials is easy to obtain

Inactive Publication Date: 2020-06-12
苏州沃立医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Most traditional wound repair pharmaceutical preparations have problems such as high toxicity and irritation, or obvious foreign body sensation of polymer materials and poor effect
Chitosan is a secondary product obtained from chitin through biodegradation or other methods. It has certain physiological activities, such as repairing wounds and inhibiting bacteria. However, it has poor water solubility and low repairing effect after acting on wounds.
Oligochitosan is a derivative of chitosan degraded under specific conditions. It has the advantages of unique spatial configuration, high water solubility, stable chemical structure, and strong physiological activity. However, the effect of wound repair alone is not significant.
Studies have found that combining oligochitosan with natural plant extracts under certain conditions and ratios can form a stable conjugate and make wound repair preparations, which can solve the problems of high toxicity, high irritation, or high Problems such as obvious foreign body sensation and poor effect of molecular materials

Method used

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  • Medicinal preparation for repairing wounds, and preparation method thereof
  • Medicinal preparation for repairing wounds, and preparation method thereof
  • Medicinal preparation for repairing wounds, and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Dissolve 20g of chitosan with 800ml of acetic acid, the concentration of chitosan is 0.025g / ml, add 20ml of mixed enzyme composed of apple protease and papain to hydrolyze, hydrolyze at 45°C for 30mim, inactivate the enzyme at 110°C for 15min, centrifuge to take the supernatant, Freeze-dry to obtain 18.52 g of oligochitosan. Through LC-MS test, it is confirmed that it is oligochitosan, the average molecular weight is 1260, and the purity is more than or equal to 99%.

[0016] Wherein, the chitosan was purchased from Jinan Haidebei Marine Engineering Co., Ltd., with a deacetylation degree of 95%, a moisture content of 4.6%, ash content of 0.5%, and a viscosity-average molecular weight of 100,000.

[0017] The LC-MS test results of the oligochitosan obtained in this example are: the average molecular weight is 1260, and the purity is more than or equal to 99%.

Embodiment 2

[0019] A pharmaceutical preparation for repairing wounds, comprising the following components by weight: 5 g of oligochitosan, 2 g of Auranthus chinensis, 2 g of Galla chinensis, 2 g of southern bamboo, 2 g of glycerin, 2 g of polyethylene glycol with a molecular weight of 600, and 85 mL of distilled water; Wherein said oligochitosan is prepared in Example 1.

[0020] The preparation method of the above-mentioned medicinal preparation for repairing wounds is as follows: In a 1000ml flask, add 2g of Auranthus chinensis, 2g of Galla gall, 2g of Southern bamboo, mix with 500ml of 80% ethanol, fully stir to make it evenly mixed, and heat to reflux for 3 hours Afterwards, the insoluble matter was filtered off, and concentrated under reduced pressure to 100ml. Then cool the concentrated solution to 1°C, place it for 24 hours and filter to remove the insoluble matter, concentrate the filtrate to dryness, add 50ml of distilled water to dissolve, cool to 1°C, let it stand for 48 hours,...

Embodiment 3

[0022] A pharmaceutical preparation for repairing wounds, comprising the following components by weight: 5 g of oligochitosan, 1 g of Auranthus chinensis, 3 g of Galla chinensis, 2 g of southern bamboo, 4 g of glycerin, 3 g of polyethylene glycol with a molecular weight of 600, and 82 mL of distilled water; Wherein said oligochitosan is prepared in Example 1.

[0023] The preparation method of the above-mentioned medicinal preparation for repairing wounds is as follows: In a 1000ml flask, add 1g of Aurantia chinensis, 3g of Galla gall, 2g of Southern Bamboo, mix with 500ml of 80% ethanol, stir well to make it evenly mixed, and heat to reflux for 3 hours Afterwards, the insoluble matter was filtered off, and concentrated under reduced pressure to 100ml. Then cool the concentrated solution to 1°C, place it for 24 hours and filter to remove the insoluble matter, concentrate the filtrate to dryness, add 50ml of distilled water to dissolve, cool to 1°C, let it stand for 48 hours, f...

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Abstract

The invention discloses a medicinal preparation for repairing wounds, and a preparation method thereof. The medicinal preparation comprises the following components: oligochitosan, callicarpa bodinieri, gallnut, nandina domestica, glycerol, polyethylene glycol and distilled water. The preparation method comprises the following steps: sequentially adding callicarpa bodinieri, gallnut, nandina domestica and ethanol into a reaction bottle; uniformly stirring, carrying out heating reflux, extracting the filtrate, concentrating under reduced pressure, cooling, standing, filtering to remove insoluble substances, concentrating to be dry, adding distilled water to dissolve, cooling, standing, filtering to remove insoluble substances, sequentially adding oligochitosan, glycerol and polyethylene glycol with the molecular weight of 600, stirring to fully dissolve, and adding distilled water to fix the volume to obtain the medicinal preparation for repairing wounds. The medicinal preparation disclosed by the invention is non-toxic, remarkable in wound repair effect and small in irritation, and has relatively great clinical application value and social benefit when being used for repairing wounds, wherein the preparation raw materials of the medicinal preparation are easy to obtain, the preparation method is simple, and industrialization is convenient to achieve.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a pharmaceutical preparation for repairing wounds and a preparation method. Background technique [0002] Most of the traditional wound repair pharmaceutical preparations have problems such as high toxicity and irritation, or obvious foreign body sensation of polymer materials and poor effect. Chitosan is a secondary product obtained from chitin through biodegradation or other methods. It has certain physiological activities, such as repairing wounds and inhibiting bacteria. However, it has poor water solubility and low repairing effect after acting on wounds. Oligochitosan is a derivative of chitosan degraded under specific conditions. It has the advantages of unique spatial configuration, high water solubility, stable chemical structure, and strong physiological activity. However, the effect of wound repair alone is still not significant. Studies have found...

Claims

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Application Information

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IPC IPC(8): A61K36/85A61K9/08A61K47/26A61K47/10A61P17/02
CPCA61K9/0014A61K9/08A61K35/64A61K36/29A61K36/85A61K47/10A61K47/26A61K2236/333A61P17/02A61K2300/00
Inventor 陆昊王卫华张雪华张建平
Owner 苏州沃立医疗科技有限公司