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Preparation method of L-methionine

A technology of methionine and acetyl, applied in the field of preparation of L-methionine, can solve the problems of impurity of L-methionine, enterprise loss, product quality not meeting sales requirements, etc.

Active Publication Date: 2020-06-12
湖北省八峰药化股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in the enzymatic preparation process, L-methionine is often impure due to the defects of the process itself or process control factors, mainly because a small amount of D-methionine is mixed in the L-methionine, so that the optical activity of the L-methionine product cannot meet the requirements. In the end, the quality of the product cannot meet the sales requirements, and the company suffers huge losses.

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  • Preparation method of L-methionine

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preparation example Construction

[0034] In view of this, the present invention proposes a preparation method of L-methionine, starting from the process of improving the enzymatic production of L-methionine, and realizing the purpose of the optical rotation of the finished product of L-methionine, figure 1 Shown is an example of the preparation method of L-methionine provided by the present invention. see figure 1 Shown, in this embodiment, the preparation method of described L-methionine comprises the following steps:

[0035] Step S10, acetylating DL-methionine to obtain an acetylated product containing N-acetyl-DL-methionine;

[0036] In this example, the method of acetylating DL-methionine to generate N-acetyl-DL-methionine is as follows: DL-methionine is mixed with NaOH and acetic anhydride, and the acetylation reaction is carried out at a temperature of 35-50°C to obtain the N-acetyl-DL-methionine. An acetylation product of N-acetyl-DL methionine; wherein, the mass ratio of DL-methionine, NaOH and acet...

Embodiment 1

[0059] (1) Mix commercially available DL-methionine with NaOH and acetic anhydride (the mass ratio of the three is 1:0.4:0.6), and carry out acetylation reaction at a temperature of 40°C to obtain N-acetyl-DL-methionine Acetylation products;

[0060] (2) Suction filter the acetylated product obtained in step (1) and collect the solid matter, and then dry it at a temperature of 55° C. to obtain a mixture of N-acetyl-DL methionine;

[0061] (3) Dissolving the N-acetyl-DL methionine mixture obtained in step (2) in absolute ethanol, then suction filtering and collecting the filtrate;

[0062] (4) under the vacuum of 0.03MPa, the filtrate obtained in step (3) is heated and distilled until the solvent is completely volatilized, and then the solid matter obtained by distillation is collected to obtain N-acetyl-DL methionine;

[0063] (5) Put the N-acetyl-DL methionine obtained in step (4) into the enzymolysis tank, then add aminoacylase and an appropriate amount of water to form the...

Embodiment 2

[0067] (1) Mix commercially available DL-methionine with NaOH and acetic anhydride (the mass ratio of the three is 1:0.2:0.3), and perform an acetylation reaction at a temperature of 35°C to obtain N-acetyl-DL-methionine. Acetylation products;

[0068](2) adding diameter to the acetylation product that step (1) obtains is the glass microsphere of 2.5mm (the mass ratio of glass microsphere and acetylation product is 1:10), then suction filtration and collect solid matter, solid The substance is dried at a temperature of 50° C. to obtain a mixture of N-acetyl-DL methionine;

[0069] (3) Dissolving the N-acetyl-DL methionine mixture obtained in step (2) in absolute ethanol, then suction filtering and collecting the filtrate;

[0070] (4) under the vacuum of 0.01MPa, the filtrate obtained in step (3) is heated and distilled until the solvent is completely volatilized, and then the solid matter obtained by distillation is collected to obtain N-acetyl-DL methionine;

[0071] (5) P...

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Abstract

The invention discloses a preparation method of L-methionine. The method comprises the following steps: carrying out acetylation treatment on DL-methionine to obtain an acetylation product with N-acetyl-DL methionine; carrying out suction filtration on the acetylation product, collecting a solid substance, and drying to obtain an N-acetyl-DL methionine mixture; dissolving the N-acetyl-DL methionine mixture into absolute ethyl alcohol, then carrying out suction filtration, and collecting a filtrate; carrying out reduced pressure distillation on the filtrate, and then collecting solid substancesto obtain N-acetyl-DL methionine; carrying out enzymolysis and decoloration treatment on the N-acetyl-DL methionine so as to obtain a product solution with L-methionine; and carrying out reduced pressure crystallization on the product solution, collecting a crystallized solid, removing impurities from the crystallized solid by using an ethanol solution, and drying to obtain L-methionine. According to the preparation method of the L-methionine, purity of the L-methionine is improved, and optical rotation quality of the L-methionine is increased.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of L-methionine. Background technique [0002] Methionine is also known as methionine, and its chemical name is 2-amino-4-methylmercaptobutyric acid. Methionine is an essential amino acid that has important nutritional value for the human body. Methionine maintains the growth and development of the body and nitrogen balance, and has a certain effect on the synthesis of choline and liver fat from adrenaline in medicine; Treatment; Methionine can be used as an adjuvant treatment for poisoning such as sulfonamides, arsenic or benzene, and can also be used as a choleretic. In the feed industry, methionine is one of the most important amino acids necessary for livestock and poultry to synthesize animal protein. It is a fortifier for protein feed and a nutritional additive to make up for the balance of amino acids. Since methionine cannot be synthesized in anima...

Claims

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Application Information

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IPC IPC(8): C12P13/12C07C319/20C07C319/28C07C323/59C07C323/58
CPCC12P13/12C07C319/20C07C319/28C07B2200/07C07C323/59C07C323/58
Inventor 梅运军张笑迎张小萱曾仪维程思俊
Owner 湖北省八峰药化股份有限公司
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