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Application of rotigotine microspheres in preparation of medicine for treating inflammatory pain
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An inflammatory pain, microsphere technology for biomedical applications
Inactive Publication Date: 2020-06-16
YANTAI UNIV
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[0005] At present, the research on rotigotine mainly includes the preparation method, analysis method, application, new preparation of rotigotine and its derivatives, and the treatment of Parkinson's disease, Parkinson-plus syndrome, depression caused by dopaminergicnervous system damage. There are no reports on the analgesic effect of rotigotine microsphere preparations in these aspects.
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Embodiment 1
[0021] Example 1: Analgesic effect and results of rotigotine microspheres on carrageenan-induced inflammatory pain
[0022] Materials and Reagents
[0023] Rotigotine Microspheres (Specification: 42mg / bottle, made by Shandong Luye Pharmaceutical Co., Ltd.); Rotigotine Microspheres Vehicle (made by Shandong Luye Pharmaceutical Co., Ltd.); Carrageenan (Sigma-Aldrich, USA)
[0026] Thermal stimulation was measured on the YLS-6B intelligent hot plate instrument. During the experiment, the temperature of the hot plate was kept at 52±0.2 °C. The timing was started from the time of contact, and the time until the...
Embodiment 2
[0029] Example 2: Determination results of rotigotine microspheres on carrageenan-induced inflammatory tissue pain-causing substances
[0030] Materials and Reagents
[0031] Rotigotine Microspheres (Specification: 42 mg / bottle, made by Shandong Luye Pharmaceutical Co., Ltd.); Rotigotine Microspheres Vehicle (made by Shandong Luye Pharmaceutical Co., Ltd.); ChloralHydrate (Sinopharm Chemical Reagent Co., Ltd.) ; Carrageenan (Sigma-Aldrich, USA); Rat PGE2 ELISA Kit (Shanghai EnzymeBiotechnology Co., Ltd.)
[0034] After the three groups of rats in Example 1...
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technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of rotigotine microspheres in the preparation of medicines for treating inflammatory pain. Background technique [0002] Rotigotine is a non-ergot dopaminereceptoragonist that produces anti-parkinsonian effects by stimulating dopamine D3 / D2 / D1 receptors. In primate and rodent Parkinsonian models induced by 6-hydroxydopa and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, rotigotine exhibited significant anti-Parkinsonism Jinsen effect and neuroprotection, and continuous administration of rotigotine can reduce the occurrence of motor complications compared with pulsed administration of levodopa and rotigotine. [0003] Rotigotine Sustained-release Microspheres for Injection (LY03003) developed by Luye Pharma has completed phase I clinical trials in China and the United States respectively and has been exempted from phase II clinical trials, and is currently ...
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