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Compound preparation for preventing transplant rejection after renal transplantation

A technology of transplant rejection and compound preparations, which is applied in the field of compound preparations for the prevention of transplant rejection after kidney transplantation, can solve problems such as thrombocytopenia, achieve the effects of reducing side effects, improving thrombocytopenia, and relieving headaches

Inactive Publication Date: 2020-06-19
ZHUOHE PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, using ezetimibe alone may cause side effects such as headache, abdominal pain, and thrombocytopenia

Method used

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  • Compound preparation for preventing transplant rejection after renal transplantation
  • Compound preparation for preventing transplant rejection after renal transplantation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] This embodiment discloses a compound preparation for preventing transplant rejection after kidney transplantation, including the following components in parts by weight:

[0028] Component weight Tacrolimus5g mixture30g Methyl cellulose: Claw ear gum = 1:3 (weight ratio)30g Corn starch: MCC101=3:1 (weight ratio)30g Povidone K304g Magnesium stearate 1g

[0029] In this case, the preparation method of the compound preparation for preventing transplant rejection after kidney transplantation includes the following steps:

[0030] S1. Put tacrolimus into a jet mill for micronization. D90 is required to be 5-12μm.

[0031] S2. The mixture is composed of white peony root, Chuanqiong, Taizi ginseng, licorice, Ziheche, Yinchen, and Cnidium in any proportion, and is made into very fine powder by a fine powder grinder.

[0032] S3. Weigh the prescribed amount of sustained-release materials, fillers, binders, and lubricants, and pass them through an 80-mesh sieve for use.

[0033] S...

Embodiment 2

[0041] This embodiment discloses a compound preparation for preventing transplant rejection after kidney transplantation, including the following components in parts by weight:

[0042] Component weight Tacrolimus8g mixture30g Methyl cellulose: Claw ear gum = 1:3 (weight ratio)24g Corn starch: MCC101=3:1 (weight ratio)33g Povidone K304g Magnesium stearate 1g

[0043] In this case, the preparation method of the compound preparation for preventing transplant rejection after kidney transplantation includes the following steps:

[0044] S1. Put tacrolimus into a jet mill for micronization. D90 is required to be 5-12μm.

[0045] S2. The mixture is composed of white peony root, Chuanqiong, Taizi ginseng, licorice, Ziheche, Yinchen, and Cnidium in any proportion, and is made into a very fine powder by a fine powder grinder.

[0046] S3. Weigh the prescribed amount of sustained-release materials, fillers, binders, and lubricants, and pass them through an 80-mesh sieve for use.

[0047]...

Embodiment 3

[0055] This embodiment discloses a compound preparation for preventing transplant rejection after kidney transplantation, including the following components in parts by weight:

[0056] Component weight Tacrolimus10g mixture25g Methyl cellulose: Claw ear gum = 1:3 (weight ratio)20g Corn starch: MCC101=3:1 (weight ratio)36g Povidone K306g Magnesium stearate 3g

[0057] The preparation method includes the following steps:

[0058] S1. Put tacrolimus into a jet mill for micronization. D90 is required to be 5-12μm.

[0059] S2. The mixture is composed of white peony root, Chuanqiong, Taizi ginseng, licorice, Ziheche, Yinchen, and Cnidium in any proportion, and is made into very fine powder by a fine powder grinder.

[0060] S3. Weigh the prescribed amount of sustained-release materials, fillers, binders, and lubricants, and pass them through an 80-mesh sieve for use.

[0061] S4. Prepare the adhesive with 70% ethanol as a solvent to prepare an 8% adhesive solution for later use.

[...

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Abstract

The invention discloses a compound preparation for preventing transplant rejection after renal transplantation. The compound preparation comprises tacrolimus, a mixture comprised by radix paeoniae alba, rhizoma ligustici, radix pseudostellariae, radix glycyrrhizae, placenta hominis, herba artemisiae scopariae, and fructus cnidii in random proportion, sustained-release materials, fillers, binders,and lubricants. Compared with exclusive use of tacrolimus, the compound preparation can effectively reduce side effects, relieve symptoms of headaches, abdominal pain and the like, especially has a significant improvement on thrombocytopenia, has beneficial effects of effectively benefiting qi and nourishing blood, supplementing human energy, and strengthening immunologic function of human body.

Description

Technical field [0001] The invention relates to the technical field of medical preparations, in particular to a compound preparation for preventing transplant rejection after kidney transplantation. Background technique [0002] my country performs 5000 to 10,000 kidney transplants every year, and the cumulative number of cases is increasing year by year. In order to prevent and treat postoperative rejection after kidney transplantation, postoperative medication is very important. Tacrolimus (Tac; FK506) is an immunosuppressant developed by Fujisawa Pharmaceutical Co., Ltd., and is a macrolide compound It is mainly used to prevent and treat graft rejection after liver and kidney transplantation. Its effect is significantly stronger than cyclosporin A. It is currently a first-line immunosuppressant with increasingly widespread clinical application. However, ezetimibe alone may cause side effects such as headache, abdominal pain, and thrombocytopenia. [0003] Among them, thrombocy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61P37/06A61P13/12A61K31/436A61K35/50
CPCA61K31/436A61K35/50A61K36/234A61K36/236A61K36/282A61K36/36A61K36/484A61K36/65A61K36/71A61P13/12A61P37/06A61K2300/00
Inventor 沈维丹黄红红李标有
Owner ZHUOHE PHARM GRP CO LTD
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