Feeding equipment suitable for solventing-out crystallization or reaction crystallization
A technology of reaction crystallization and dissolution crystallization, which is applied in solution crystallization, evaporation separation crystallization, filtration circuit, etc., can solve the problems that cannot be solved by the crystallization method, and achieve the improvement of drug efficacy and product competitiveness, pure color, and dissolution fast speed effect
Active Publication Date: 2020-06-30
TIANJIN UNIV
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Problems solved by technology
[0005] For the above practical problems such as powder agglomeration, there is no effective crystallization method to solve the problem, and conventional methods such as the transformation of the crystallization method, the strengthening of the crystallization process, and the design of the crystallizer structure have not solved the problem.
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[0038] The following examples further illustrate the present invention, but not as a limitation of the present invention.
[0039] The present invention takes the substance atorvastatin calcium as an example to demonstrate the effect of the device of the present invention.
[0040] Verify that the test equipment sketch of the present invention is as attached Figure 4 As shown, the description of each component is as follows:
[0041]1) Voltage and flow stabilization device: A 50mL syringe is used to hold the methanol feed liquid, and a dual-channel syringe pump is used to drive two syringes to form two equal streams with a constant flow rate, thus forming a voltage and flow stabilization device;
[0042] 2) Filter: The filter membrane of the medical infusion set is used as the filter membrane for filtering the methanol feed liquid;
[0043] 3) Preheating pipe section: It is made of No. 7 stainless steel needle with a length of 20cm, the outer diameter is 0.71mm, and the inn...
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Abstract
The invention relates to feeding equipment suitable for solventing-out crystallization or reaction crystallization. The equipment is composed of four parts, namely a pressure and flow stabilizing device, a filter, a preheating pipe section and a bent pipe opening; the lower end of the pressure and flow stabilizing device is connected with the filter; a filter outlet is connected with the preheating pipe section, the tail end of the preheating pipe section is connected with the bent pipe opening, and the wall thickness of an outlet pipe wall of the bent pipe opening is gradually changed to be close to zero. The bending angle alpha of the bent pipe opening ranges from 60 degrees to 120 degrees. And after the solution in a crystallizer reaches a stable state, a raw material solution is addedinto the solution by using the feeding equipment, the bent pipe opening is arranged below the liquid level, and the outlet direction of the bent pipe opening is along the tangential direction of the circumference swept by a stirring blade tip near the circumference swept by the stirring blade tip. According to the feeding equipment, the mixing process of solution can be shortened, mixing of fluidis promoted, lump coalescent particles can be prevented from being generated in the crystallization process to the maximum extent, and more monodisperse crystals are formed.
Description
technical field [0001] The application relates to a solution mixing device, which is especially suitable for feeding equipment for elution crystallization or reaction crystallization. Background technique [0002] The elution crystallization is by changing the composition of the solvent in the solution, so that the dissolved amount of the solute in the mixed solvent decreases, so that the solute is precipitated in the form of crystals. In this case, as soon as the two solutions come into contact and mix, the local solvent composition of the crystallization system changes and crystals precipitate out. Therefore, the time for crystallization in the dissolution and crystallization process is very short, and the process of crystallization is very fast and difficult to control. Therefore, the key to the dissolution and crystallization process is to control the local mixing process. [0003] Similar to the dissolution and crystallization process, in the reaction crystallization ...
Claims
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IPC IPC(8): B01D9/02B01D36/00C07D207/34
CPCB01D9/0027B01D36/00C07D207/34
Inventor 龚俊波秦春雷侯晓清侯宝红吴送姑郭盛争
Owner TIANJIN UNIV