Octacosanol composition used for improving microcirculation and lowering blood fat, and application

A technology of octacosanol and composition, which is applied in the direction of application, drug combination, active ingredient of hydroxyl compound, etc.

Active Publication Date: 2020-07-03
南京昌润生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the application of octacosanol in drugs or health foods to improve microcirculation

Method used

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  • Octacosanol composition used for improving microcirculation and lowering blood fat, and application
  • Octacosanol composition used for improving microcirculation and lowering blood fat, and application
  • Octacosanol composition used for improving microcirculation and lowering blood fat, and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1 Preparation of Octacosanol Composition for Improving Microcirculation and Lowering Blood Lipid

[0026] 5 g of octacosanol, 160 g of Panax notoginseng extract, 165 g of salvia miltiorrhiza extract, 4 g of silicon dioxide, and 26 g of lactose were evenly mixed to obtain a octacosanol composition for later use.

[0027] The obtained octacosanol composition powder was directly filled to prepare octacosanol composition capsules, each capsule containing 360 mg of the octacosanol composition.

Embodiment 2

[0028] Embodiment 2 Rat comparative test

[0029] Take 40 Wistar rats, half male and half male, first adapted to feeding for 3 days, weighed and divided into groups. Randomly divided into 4 groups (group 1-4), 10 in each group. Rats were gavaged once a day for 30 days. On the 31st day of the experiment, anesthetized by intraperitoneal injection of 10% chloral hydrate, blood was collected from the abdominal aorta, centrifuged (3000r / min) for 15min, and serum was separated and prepared.

[0030] In this embodiment, the experimental grouping is as follows:

[0031] Group 1: octacosanol;

[0032] Group 2: Danshen extract + Astragalus extract (mass ratio 1:1);

[0033] Group 3: Octacosanol + Danshen extract + Astragalus extract (the mass ratio of the three is 1:32:33);

[0034] Control group: Feed only.

[0035] The contents of serum triglyceride (TG), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C) and total cholesterol (TC) were measured by automatic bioch...

Embodiment 3 28

[0039] Example 3 Toxicity detection test of octacosanol composition

[0040] 1. Mouse detection:

[0041] 1.) Materials and methods:

[0042] 1.1) Sample:

[0043] Packed in plastic bottles, stored at room temperature, cool and dark, with a shelf life of 24 months, the test sample is the octacosanol composition capsule obtained in Example 1, and the capsule content is light brown powder.

[0044] 1.2) Test animals:

[0045] 40 healthy ICR mice, half male and half female, weighing 18.3-22.0 g; license number for barrier environment experimental animal facilities: SYXK (Su) 2012-0037; sterilized mouse feed and sterile water free to eat.

[0046] 1.3) Test method:

[0047] Maximum tolerated dose test method. Dose selection and test substance administration: the designed dose is 15000mg / kg b.wt., weigh 15000mg of sample and add purified water to 40ml to prepare the test substance. After fasting overnight, the mice were given two oral gavages, with an interval of 4 hours in b...

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Abstract

The invention discloses an octacosanol composition used for improving microcirculation and lowering blood fat, and application. The octacosanol composition comprises octacosanol, radix notoginseng extracts and radix salviae miltiorrhizae extracts. The formed compound preparation combines the advantages of each ingredient, an animal experiment proves that the octacosanol composition can be used forpreparing a medicine / health care food capable of lowering the blood fat and improving the microcirculation, and the octacosanol composition has an obvious synergistic effect.

Description

technical field [0001] The application relates to the field of health food, in particular to an octacosanol composition and its application in the preparation of a traditional Chinese medicine composition for improving human microcirculation function. Background technique [0002] Microcirculation refers to the blood circulation between arterioles and venules, and is an exchange place for tissue cells to absorb nutrients and oxygen and discharge metabolic waste. A variety of diseases (such as hypertension, coronary heart disease, diabetes, cerebral thrombosis, gastrointestinal diseases, etc.) are closely related to microcirculation. Whether the function of microcirculation is normal or not is an important symbol of human health. Blood stasis syndrome is a disease described by traditional medical theory. It refers to the symptoms of poor blood flow in the human body, blocked blood vessels or blood disease outside the veins, and stops accumulating as stasis. Blood stasis syn...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61P3/06A61P7/02A23L33/12A23L33/10A61K31/045
CPCA61K31/045A61K36/258A61K36/537A61P3/06A61P7/02A23L33/12A23L33/10A23V2002/00A61K2300/00A23V2200/326A23V2200/3262A23V2250/21A23V2250/612A23V2250/1628A23V2250/126
Inventor 不公告发明人
Owner 南京昌润生物科技有限公司
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