Magnetic nanoparticle

A magnetic nanoparticle, responsive technology, used in allergic diseases, wave energy or particle radiation treatment materials, medical preparations of non-active ingredients, etc.

Pending Publication Date: 2020-07-03
XIAN TISSUE ENG & REGENERATIVE MEDICINE RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, nanoparticle delivery of exosomes, especially endogenous exosomes, has been less studied

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0171] This embodiment provides a magnetic nanoparticle, the magnetic nanoparticle includes a core, a shell and a halo, the shell covers the core, and the halo covers the shell.

[0172] In some embodiments, the halo further comprises proteins, polypeptides, polysaccharides, aptamers or ions.

[0173] In some embodiments, the halo further comprises a pH responsive group.

[0174] In some embodiments, the pH responsive group responds under neutral or acidic conditions.

[0175] In some embodiments, the pH-responsive groups include hydrazone linkages, ester linkages and aldehyde groups.

[0176] In some embodiments, the protein is selected from transmembrane tetramolecular proteins.

[0177] In some embodiments, the transmembrane tetramolecular protein is selected from one or more of CD9, CD63 and CD81.

[0178] In some embodiments, the polypeptide is selected from CP05.

[0179] In some embodiments, the protein is linked to the halo through the pH responsive group.

[0180...

Embodiment 2

[0213] This embodiment provides a magnetic nanoparticle that can transfer exosomes, and the active ingredient of the magnetic nanoparticle that can transfer exosomes is the magnetic nanoparticle described in Example 1.

[0214] In some embodiments,

[0215] The core of the magnetic nanoparticle of the transferable exosome is ferric oxide,

[0216] The shell of the magnetic nanoparticle of the transferable exosome is silicon dioxide,

[0217] The halo of the magnetic nanoparticles that can transfer exosomes is a hydrazone bond-polyethylene glycol-aldehyde group,

[0218] The antibody of the exosome-transferable magnetic nanoparticle is linked to the halo through an aldehyde group.

[0219] In some embodiments, the antibodies to the magnetic nanoparticles that can transfer exosomes comprise anti-CD63 monoclonal antibodies and anti-MLC monoclonal antibodies.

Embodiment 3

[0221] This embodiment provides a composition comprising magnetic nanoparticles.

[0222] In some embodiments, the magnetic nanoparticles comprise a core, a shell covering the core, and a halo covering the shell.

[0223] In some embodiments, the halo further comprises proteins, polypeptides, polysaccharides, aptamers or ions.

[0224] In some embodiments, the halo further comprises a pH responsive group.

[0225] In some embodiments, the pH responsive group responds under neutral or acidic conditions.

[0226] In some embodiments, the pH-responsive groups include hydrazone linkages, ester linkages and aldehyde groups.

[0227] In some embodiments, the protein is selected from transmembrane tetramolecular proteins.

[0228] In some embodiments, the transmembrane tetramolecular protein is selected from one or more of CD9, CD63 and CD81.

[0229] In some embodiments, the polypeptide is selected from CP05.

[0230] In some embodiments, the protein is linked to the halo throu...

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Abstract

The invention provides a magnetic nanoparticle. The magnetic nanoparticle comprises a core, a shell and a halo, wherein the shell covers the core, and the halo covers the shell. The magnetic nanoparticle has targeted property, magnetic property, pH responsiveness and light sensitivity.

Description

technical field [0001] The invention relates to the field of functional magnetic microspheres, in particular to magnetic nanoparticles and applications thereof. Background technique [0002] Extracellular vesicles (EVs) include exosomes, microvesicles, and apoptotic bodies. They are small membranous vesicles released by the body outside the cells. Play an important regulatory role. Among them, exosomes (Exosomes, EXO, 30-150nm), as a carrier that can transmit biological information over a long distance, participate in the regulation of important cell physiological activities, and play an important role in maintaining tissue homeostasis, immune response, apoptosis, angiogenesis, and inflammation. Sexual response and other physiological and pathological processes play an important role. The function of exosomes depends on their quantity, transport and distribution in the system. Exosomes may regulate the immune function of the body, promote the formation of microenvironment b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/69A61K47/68A61K39/395A61K41/00A61K47/54A61K47/60A61K47/61A61K47/62A61K47/02A61P9/00A61P9/10A61P31/12A61P35/00A61P37/02
CPCA61K39/3955A61K41/00A61K47/02A61K47/549A61K47/60A61K47/61A61K47/62A61K47/6843A61K47/6925A61P9/00A61P9/10A61P31/12A61P35/00A61P37/02A61K2300/00
Inventor 鲍丽丽刘文婷
Owner XIAN TISSUE ENG & REGENERATIVE MEDICINE RES INST
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