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Method for catalytic oxidation and functional modification of hydrogel material

A catalytic oxidation and hydrogel technology, applied in fermentation and other directions, can solve the problems of protein adsorption capacity, low light permeability, etc.

Active Publication Date: 2020-07-07
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The modified hydrogel material prepared by the method of the present invention is conducive to solving the problems encountered when wearing contact lenses based on the pHEMA hydrogel material on the market, and has high moisture retention, low protein adsorption capacity, good appearance, and light permeability. And the advantages of constant refractive index

Method used

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  • Method for catalytic oxidation and functional modification of hydrogel material
  • Method for catalytic oxidation and functional modification of hydrogel material
  • Method for catalytic oxidation and functional modification of hydrogel material

Examples

Experimental program
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Effect test

Embodiment 1-1

[0057] The hydrogel material of this embodiment is a contact lens containing pHEMA (Bausch & Lomb's colorful annual disposable contact lens, purchased from Bausch & Lomb's self-operated flagship store in JD.com).

Embodiment 1-2-1

[0059] The preparation method of the hydrogel material of the present embodiment comprises the following steps:

[0060] Step 1. Mix and shake 3g hydroxyethyl methacrylate, 90mg ethylene glycol dimethacrylate and 7mg initiator until dissolved to obtain a mixture; the initiator is Irgacure184, and the mixing and shaking time is 5min; The molecular weight of the hydroxyethyl methacrylate is 130.14g / mol, product number 17348; the molecular weight of the ethylene glycol dimethacrylate is 198.22g / mol, the product number 335681; the hydroxyethyl methacrylate and Both ethylene glycol dimethacrylate was purchased from Sigma-Aldrich, and both hydroxyethyl methacrylate and ethylene glycol dimethacrylate were removed with inhibitor scavengers to remove the 4-methoxyphenol inhibitor before use , the inhibitor scavenger is purchased from Sigma-Aldrich, product number 306312; the molecular weight of the Irgacure184 is 204.26g / mol;

[0061] Step 2. Place the mixture described in step 1 in a...

Embodiment 1-2-2

[0066] The preparation method of the hydrogel material of the present embodiment comprises the following steps:

[0067] Step 1. Mix and shake 3g hydroxyethyl methacrylate, 90mg ethylene glycol dimethacrylate and 7mg initiator until dissolved to obtain a mixture; the initiator is Irgacure184, and the mixing and shaking time is 8min; The molecular weight of the hydroxyethyl methacrylate is 130.14g / mol, product number 17348; the molecular weight of the ethylene glycol dimethacrylate is 198.22g / mol, the product number 335681; the hydroxyethyl methacrylate and Both ethylene glycol dimethacrylate was purchased from Sigma-Aldrich, and both hydroxyethyl methacrylate and ethylene glycol dimethacrylate were removed with inhibitor scavengers to remove the 4-methoxyphenol inhibitor before use , the inhibitor scavenger is purchased from Sigma-Aldrich, product number 306312; the molecular weight of the Irgacure184 is 204.26g / mol;

[0068] Step 2. Place the mixture described in step 1 in a...

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Abstract

The invention discloses a method for catalytic oxidation and functional modification of a hydrogel material, which is characterized by comprising the following steps: step 1, soaking the hydrogel material in a buffer solution dissolved with a piperidine compound to obtain a mixed system; step 2, adding a laccase solution into the mixed system obtained in the step 1, and then introducing oxygen forcatalytic oxidation to obtain an oxidized hydrogel material; and 3, soaking the hydrogel material oxidized in the step 2 in a hyaluronic acid-adipic dihydrazide solution, and carrying out functionalmodification under a stirring condition to obtain the modified hydrogel material. The method has the advantages that the process is controllable, the water-soluble polymer range is wide, experimentalreagents are easy to obtain, large experimental equipment is not needed, and the reaction is carried out under the conditions of normal temperature and normal pressure. The modified hydrogel materialprepared by the method disclosed by the invention has the advantages of high moisture retention, low protein adsorption capacity, unchanged appearance, light permeability and refractive index and thelike.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a method for catalytic oxidation and functional modification of hydrogel materials. Background technique [0002] Polymer hydrogel is a gel with water as the dispersion medium, and its interior is composed of a cross-linked hydrophilic polymer network structure. A large amount of water is absorbed and swollen in the network structure, which appears as a quasi-flowless fluid macroscopically. net state. Hydrogel has adjustable strength and porosity, and its surface generally has strong hydrophilicity. These special properties make hydrogel have a variety of application potentials, and can be used in the industry to prepare oil-water separation membranes, etc.; and in biological In the medical field, due to its good biocompatibility, hydrogel materials are widely used in the preparation of drug delivery carriers, biosensors, anti-bioadsorption surfaces, or bio...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L33/14C08L79/02C08L33/04C08L71/02C08L5/08C08F220/20C08F222/14C08F2/48C12P7/62
CPCC08F2/48C08F220/20C08J3/075C08J2333/14C08J2405/08C08J2433/04C08J2471/02C08J2479/02C12P7/62
Inventor 邓旭东张熙尹大川王雪霆张托弟贺聪
Owner NORTHWESTERN POLYTECHNICAL UNIV
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