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Blood sugar reducing composition and application thereof

A technology of hypoglycemic composition, which is applied in the field of hypoglycemic composition, can solve the problems of limited hypoglycemic effect and high dosage, and achieve the effects of inhibiting synergistic effect, reducing drug resistance and reducing dosage

Active Publication Date: 2020-07-10
ZHENGZHOU FRUIT RES INST CHINESE ACADEMY OF AGRI SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem of limited hypoglycemic effect and high dosage of a single natural active ingredient in the prior art, the object of the present invention is to provide a hypoglycemic composition, the active ingredient of which is 3-O-methyl quercetin naringenin and naringenin; the composition has synergistic inhibition of α-glucosidase activity, and has broad application prospects in the preparation of medicines for treating diabetes, health products or food

Method used

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  • Blood sugar reducing composition and application thereof
  • Blood sugar reducing composition and application thereof
  • Blood sugar reducing composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A composition with hypoglycemic effect, its active ingredients are 3-O-methyl quercetin and naringenin; the mass concentration ratio of 3-O-methyl quercetin and naringenin in the composition It is 2:25.

[0032] In vitro inhibition of α-glucosidase activity by 3-O-methylquercetin and naringenin at a concentration ratio of 2∶25

[0033] 1.1 Materials and instruments: α-glucosidase (α-glucosidase, Sigma, 10U / mg), 4-nitrophenyl-α-D-glucopyranoside (pNPG, TOKYO Chemica Industry Co., LTD), Akka Wave sugar, corosolic acid (TOKYO Chemical Industry Co., LTD), 3-O-methyl quercetin, naringenin (Soleibao, Beijing), disodium hydrogen phosphate, sodium dihydrogen phosphate (Tianjin Damao ), TECAN infinite M200 PRO microplate reader (Teacan Group Ltd., Switzerland).

[0034] 1.2 Experimental steps:

[0035] 1.2.1 Preparation of drug solution: 3-O-methyl quercetin, naringenin, corosolic acid and acarbose were prepared into a 10 mg / mL mother solution with dimethyl sulfoxide (DMSO); ...

Embodiment 2

[0067] A composition with hypoglycemic effect, its active ingredients are 3-O-methyl quercetin and naringenin; the mass concentration ratio of 3-O-methyl quercetin and naringenin in the composition It is 1:25.

[0068] In vitro inhibition of α-glucosidase activity by 3-O-methylquercetin and naringenin at a mass concentration ratio of 1:25

[0069] 2.1 Materials and instruments: α-glucosidase (α-glucosidase, Sigma, 10U / mg), 4-nitrophenyl-α-D-glucopyranoside (pNPG, TOKYO Chemica Industry Co., LTD), Akka Wave sugar, corosolic acid (TOKYO Chemical Industry Co., LTD), 3-O-methyl quercetin, naringenin (Soleibao, Beijing), disodium hydrogen phosphate, sodium dihydrogen phosphate (Tianjin Damao ), TECAN infinite M200 PRO microplate reader (Teacan Group Ltd., Switzerland).

[0070] 2.2 Experimental steps:

[0071] 2.2.1 Preparation of drug solution: 3-O-methyl quercetin, naringenin, corosolic acid and acarbose were prepared into a 10 mg / mL mother solution with dimethyl sulfoxide (DM...

Embodiment 3

[0099] A composition with hypoglycemic effect, its active ingredients are 3-O-methyl quercetin and naringenin; the mass concentration ratio of 3-O-methyl quercetin and naringenin in the composition It is 4:25.

[0100] In vitro inhibition of α-glucosidase activity by 3-O-methylquercetin and naringenin at a concentration ratio of 4∶25

[0101] 3.1 Materials and instruments: α-glucosidase (α-glucosidase, Sigma, 10U / mg), 4-nitrophenyl-α-D-glucopyranoside (pNPG, TOKYO Chemica Industry Co., LTD), Akka Wave sugar, corosolic acid (TOKYO Chemical Industry Co., LTD), 3-O-methyl quercetin, naringenin (Soleibao, Beijing), disodium hydrogen phosphate, sodium dihydrogen phosphate (Tianjin Damao ), TECAN infinite M200 PRO microplate reader (Teacan Group Ltd., Switzerland).

[0102] 3.2 Experimental steps:

[0103] 3.2.1 Preparation of drug solution: 3-O-methyl quercetin, naringenin, corosolic acid and acarbose were prepared into a 10 mg / mL mother solution with dimethyl sulfoxide (DMSO); ...

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Abstract

The present invention discloses a blood sugar reducing composition and an application thereof, and belongs to the technical field of medicines. The blood sugar reducing composition is prepared from 3-O-methyl quercetin and naringenin according to a mass concentration ratio of (1:25) to (6:25). Preferably, the mass concentration ratio of the 3-O-methyl quercetin to the naringenin is (2:25) to (6:25). The 3-O-methyl quercetin and naringenin composition has the obvious alpha-glucosidase inhibiting synergistic effect, the effect is superior to that of a flavone compound used alone, the medicine dosage can be reduced, and the occurrence of drug resistance is reduced; and the composition has the wide application prospect in the preparation of diabetes treatment medicines, health care products orfoods.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a hypoglycemic composition and its application. Background technique [0002] In recent years, type II diabetes has developed into one of the chronic diseases that seriously endanger human health in the world. It is estimated that by 2035, the global diabetic population will reach 600 million. Studies have shown that controlling postprandial blood sugar is an effective means to prevent diabetes and prevent its complications, and inhibiting the activity of α-glucosidase on the brush border of small intestinal villous mucosa cells is a very effective way to reduce postprandial blood sugar. At present, there are acarbose, voglibose and miglibose on the market that have been used in clinical practice to lower blood sugar, but continuous use will cause some side effects. Therefore, it is imminent to discover new α-glucosidase inhibitors with less toxic side effects from ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P3/10A23L33/105
CPCA23V2002/00A61K31/352A23L33/105A61P3/10A61K2300/00A23V2200/328A23V2250/21168A23V2250/2116
Inventor 张强焦中高刘杰超张春岭刘慧吕真真杨文博陈大磊
Owner ZHENGZHOU FRUIT RES INST CHINESE ACADEMY OF AGRI SCI
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