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Application of compound COMPOUND ZZ-8 in preparation of drug for treating obesity

A technology of COMPOUNDZZ-8 and compound, which is applied in the field of preparation of anti-obesity drugs, and can solve the problems of restricting the long-term use of anti-obesity drugs

Active Publication Date: 2020-07-17
SHENZHEN XIANHU BOTANICAL GARDEN ADMINISTRATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Serious adverse reactions such as gastrointestinal or cardiovascular complications, as well as safety concerns such as mood changes and suicide, limit the long-term use of anti-obesity drugs

Method used

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  • Application of compound COMPOUND ZZ-8 in preparation of drug for treating obesity
  • Application of compound COMPOUND ZZ-8 in preparation of drug for treating obesity
  • Application of compound COMPOUND ZZ-8 in preparation of drug for treating obesity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046]

[0047] Compound COMPOUND ZZ-8

[0048] 1. The effect of compound ZZ-8 on weight loss and lipid-lowering in vivo

[0049] 1.1 Reagents and instruments

[0050] Gastrointestinal needles, feed, litter, conventional 4°C freezer, thermometer, ice machine, -80°C ultra-low temperature refrigerator, automatic biochemical analyzer (Hitachi 7080, Japan)

[0051] 1.2 Animal modeling and administration in groups

[0052] 1.2.1 Animal modeling and group administration

[0053] Six-week-old male wild-type C57BL / 6J (WT) mice were purchased from the Animal Experiment Center of Fujian Medical University (Fujian, China). Mice were maintained in a temperature-controlled animal room at 20-22°C with a 12-h light / dark cycle. C57BL / 6 mice were randomly divided into two groups, one group was fed with normal diet (9% fat; independent diet in the laboratory), and the other group was fed with high-fat diet HFD (60kcal% fat; Research Diets, USA), free to drink water until Modeling is ove...

Embodiment 2

[0074] Example 2. Effect of compound COMPOUND ZZ-8 on adipose tissue weight

[0075] 2.1 Experimental materials: The mouse tissues of each group in Example 1 were collected, cryopreserved and fixed. The mice in each experimental group completed body temperature measurement, triglyceride and cholesterol detection, weighed and recorded the final body weight. The blood was taken from the eyeball, and the neck was broken to death. Wipe the mouse body with alcohol for dissection. Immediately take the brown fat from the back of the mouse, and the subcutaneous white fat, epididymal fat, and liver, weigh the fat tissue and liver, take pictures, and observe whether there is any abnormality in the abdominal cavity of the mouse. Half of the tissues were frozen in liquid nitrogen in EP tubes, and the other half were soaked in EP tubes filled with 4% paraformaldehyde. The whole experiment should be completed as quickly as possible, and the tissues placed in liquid nitrogen were transfer...

Embodiment 3

[0084] Example 3. Effect of compound COMPOUND ZZ-8 on pathology of adipose tissue

[0085] 3.1 Experimental materials: The white fat, brown fat and epididymal fat tissues of the experimental mice obtained in Example 2 were taken for pathological section observation.

[0086] 3.2 Test method: Pathological section observation was carried out on the fixed adipose tissue of mice in each test group. Specifically, some white adipose tissue, brown adipose tissue and epididymal adipose tissue were taken, washed with normal saline, and fixed at a temperature of more than 4%. Paraformaldehyde (PFA), embedded in paraffin, and cut into 7 μm sections. Hematoxylin-eosin (HE) staining was used to observe the changes of adipocytes in IWAT of mice in each experimental group.

[0087] 3.3 Experimental results

[0088] Compound ZZ-8 on the pathological section results of white adipose tissue, brown adipose tissue and epididymal adipose tissue of obese mice induced by high-fat diet, see Figur...

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Abstract

The invention discloses an application of compound COMPOUND ZZ-8 in preparation of a drug for treating obesity. The application of the compound COMPOUND ZZ-8 or a medicinal salt thereof as an only active ingredient in the preparation of the drug for preventing and / or treating the obesity is provided, and the molecular structural formula of the compound COMPOUND ZZ-8 is shown in the specification.The inventors find that the compound COMPOUND ZZ-8 can promote the conversion of white adipose tissue to brown adipose tissue and inhibit fat absorption, so that the compound COMPOUND ZZ-8 can be usedfor the drug for preventing and / or treating the obesity; and the inventors further find that the compound COMPOUND ZZ-8 can reduce total cholesterol, reduce triglycerides, increase low high-density lipoprotein and / or reduce low-density lipoprotein, and prevent and / or treat fatty liver and hepatitis caused by the obesity, so that the compound COMPOUND ZZ-8 can be used to prepare the drug for preventing and / or treating the fatty liver and hepatitis caused by the obesity or hyperlipidemia, and is a potential drug for effectively preventing and treating the obesity, the fatty liver and hepatitiscaused by the obesity, and / or the hyperlipidemia.

Description

technical field [0001] The invention belongs to the field of weight loss, and in particular relates to the application of the compound COMPOUND ZZ-8 in the preparation of medicines for treating obesity. Background technique [0002] Since the 1970s, the phenomenon of being overweight worldwide has become increasingly common. In 2016, about 40% of adults and 18% of children (5-19 years old) in the world were overweight. The number of people converted into a specific number is: nearly 20 100 million adults and 340 million children are overweight. In 2018, 4 million people worldwide died from being overweight. The global economic impact of diseases related to overweight and obesity is estimated at $2.2 trillion. A report published in "CA: A Cancer Journal of Clinicians" shows that overweight and obesity are the second largest cancer risk factors, after smoking. [0003] The primary cause of obesity is changes in diet and lifestyle. Obesity refers to abnormal or excessive fa...

Claims

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Application Information

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IPC IPC(8): A61K31/7034A61P3/04A61P1/16A61P3/06
CPCA61K31/7034A61P1/16A61P3/04A61P3/06
Inventor 冯世秀马文玉张旻张力陈涛董慧李建友邓丽
Owner SHENZHEN XIANHU BOTANICAL GARDEN ADMINISTRATION