Application of geranyl flavone A in preparation of medicines for promoting wound healing

A technology of geranyl flavonoids and wound healing, applied in the field of medicine, can solve problems such as susceptibility to trauma, difficulty in recovery, weakened body defense ability of diabetics, etc.

Active Publication Date: 2020-07-31
HANYI BIO TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Diabetics have weakened body defense ability and low nerve sensitivity, making them vulnerable to trauma and difficult to recover. Therefore, it is urgent to develop new drugs that can effectively treat trauma

Method used

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  • Application of geranyl flavone A in preparation of medicines for promoting wound healing
  • Application of geranyl flavone A in preparation of medicines for promoting wound healing
  • Application of geranyl flavone A in preparation of medicines for promoting wound healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0134] Embodiment 1: Construction of type II diabetes model

[0135] Method for constructing type II diabetes model by using low-dose streptozotocin and high-fat diet in combination [7] It is a relatively mature method at present, and has the advantages of short time-consuming, high modeling success rate, good repeatability, and low mortality rate.

[0136] 1. Experimental animals and grouping

[0137] 25 male rats (C57BL / 6, purchased from Victoria Lihua) aged 6-8 weeks, with an average body weight of more than 20 g.

[0138] Control group (control): 5 rats were intraperitoneally injected with 0.1 mmol / L citrate buffer solution at pH 4.2.

[0139] Experimental group (STZ): 50 rats, intraperitoneally injected with 1% streptozotocin; 25 rats were randomly selected for statistics.

[0140] 2. Model making method

[0141] Before modeling, the initial blood glucose and body weight of the mice were detected on an empty stomach, as follows: Figure 1A , Figure 1C shown.

[0...

Embodiment 2

[0147] Embodiment 2: skin wound healing experiment

[0148] 1. Experimental method

[0149] (1) Construction of skin wound model

[0150] C57 wild adult male mice (C57BL / 6, purchased from Victoria Lihua Company) were taken, the back hair was depilated after anesthesia, and a full-thickness wound was constructed with a 6mm biopsy punch. Pay attention to disinfection and prevent infection.

[0151] (2) Grouping and administration method

[0152] Normal control group: 5 rats, no administration.

[0153] Vaseline group: Vaseline (medical Vaseline, purchased from Tianjin Zhiyuan Chemical Reagent Co., Ltd., the same below), 5 mg Vaseline per mouse, 5 mice.

[0154] Drug A group: 10 mg / rat, 10 rats (flavone control, drug A is soybean isoflavone).

[0155] B drug group: 10 mg / rat, 10 rats (flavonoid control, B drug is quercetin).

[0156] Cannflavin A group: Cannflavin A, 10 mg / rat, 10 rats.

[0157] The administration methods of the latter 4 groups were all applied to the woun...

Embodiment 3

[0170] Embodiment 3: the skin wound healing experiment of staphylococcus aureus infection (1)

[0171] The wounds of diabetic patients are not only difficult to heal but also prone to infection. Staphylococcus aureus is the most common pathogen in human suppurative infection, which can cause local suppurative infection, pneumonia, pseudomembranous enteritis, pericarditis, etc., and even sepsis and sepsis Wait for systemic infection. In this study, Staphylococcus aureus was used to construct a skin infection model of diabetic mice [8] , which aims to be closer to the diseases of human wounds that are not easy to heal, making the research more meaningful.

[0172] 1. Experimental method

[0173] (1) Model making method

[0174] Take normal mice as controls and type Ⅱ diabetic mice constructed according to the method in Example 1, and after anesthetizing and hair removal on the back, construct full-thickness wounds with a 6 mm biopsy punch. Inoculate 1.5x10 6 CFU / ml Staphy...

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Abstract

The invention belongs to the field of medicines, and relates to an application of geranyl flavone A in preparation of medicines for promoting wound healing. Specifically, the invention relates to an application of geranyl flavone A in preparation of medicines for promoting wound healing of type II diabetes mellitus. The geranyl flavone A can effectively promote wound healing and has a potential ofbeing used for preparing medicines for promoting wound healing, especially preventing and treating diabetic feet.

Description

technical field [0001] The invention belongs to the field of medicine and relates to the use of geranyl flavone A in the preparation of medicines for promoting wound healing. Specifically, the present invention relates to the use of geranyl flavone A in the preparation of drugs for promoting wound healing in type II diabetes. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by hyperglycemia, often divided into type I, type II and gestational diabetes [1] . Type I diabetes formerly known as insulin-dependent diabetes [2] , with a higher incidence in children and adolescents, and can also occur at various ages. The onset is relatively sharp, and there is absolutely insufficient insulin in the body, and ketoacidosis is prone to occur. Insulin must be used to treat it, otherwise it will be life-threatening. Type II diabetes formerly known as adult-onset diabetes [3] , mostly after the age of 35-40, accounting for more than 90% of diabetic...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61K31/352A61K45/06A61P17/02A61P3/10A61P31/04
CPCA61K36/60A61K31/352A61K45/06A61P17/02A61P3/10A61P31/04A61K2300/00
Inventor 李向东张可谭昕于朝晖常坦然连萌
Owner HANYI BIO TECH CO LTD
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