Application of litchi pulp polyphenol extract in preparation of preparation for improving ulcerative colitis

A technology for ulcerative colitis and lychee pulp, applied in application, drug combination, food science, etc., can solve the problem that HPD-826 macroporous resin is expensive, has not been disclosed to improve ulcerative colitis, and the acquisition rate cannot be effectively guaranteed To achieve the safe and reliable preparation method, solve the narrow application range, and improve the effect of changes in physiological indicators

Inactive Publication Date: 2020-07-31
GUANGZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The researchers found that the HPD-826 macroporous resin has a better purification effect on litchi polyphenols, but the HPD-826 macroporous resin is expensive and not suitable for industrial mass production
[0004] At present, there is no published report on the use of litchi pulp polyphenol extracts for the improvement of ulcerative colitis
At the same time, for the traditional solvent extraction method and enzyme extraction method to prepare polyphenol extracts, the steps are cumbersome and complicated, the yield cannot be effectively guaranteed, and it may cause pollution or the problem of industrial production

Method used

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  • Application of litchi pulp polyphenol extract in preparation of preparation for improving ulcerative colitis
  • Application of litchi pulp polyphenol extract in preparation of preparation for improving ulcerative colitis
  • Application of litchi pulp polyphenol extract in preparation of preparation for improving ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0034] One, the preparation of litchi pulp polyphenol extract

[0035] Concrete preparation steps are as follows:

[0036] (1) Fresh lychees are manually peeled and pitted, and the lychee pulp is mixed with 80% volume concentration of edible alcohol at a material-to-liquid ratio (mass volume ratio) of 1:2, and the mixer is crushed and beaten for 10 minutes to obtain a homogenized lychee pulp.

[0037] (2) Ultrasonic treatment is performed on the litchi pulp homogenate obtained in step (1), the ultrasonic power is 400w, and the ultrasonic time is 15 minutes.

[0038] (3) Carry out suction filtration to the litchi pulp homogenate after ultrasonic, obtain filtrate and filter residue, and repeat above-mentioned (1) (2) step once with filter residue, mix twice filtrate, place 45 ℃ of rotary evaporators to concentrate, to obtain a concentrate.

[0039] (4) The concentrated solution was eluted and purified with AB-8 macroporous resin, eluted with distilled water and edible alcohol ...

Embodiment 1

[0051] In Example 1, the mice were removed from the eyeballs and orbits to collect blood, and the blood was centrifuged to get serum to measure tumor necrosis factor α (TNF-α), IL-1β, monocyte chemoattractant protein 1 (MCP-1) and lipopolysaccharide (LPS) content.

[0052] 2. Experimental results:

[0053] The result is as figure 2 shown. The experimental results showed that the contents of TNF-α, IL-1β, LPS and MCP-1 in the DSS group were significantly higher than those in the NC group. 5-ASA+DSS group significantly decreased the levels of IL-1β, LPS and MCP-1, HP+DSS group significantly decreased the levels of TNF-α, IL-1β, LPS and MCP-1, and IL-1β and There was no significant difference in the content of LPS compared with the NC group, but the LP+DSS group did not significantly reduce the levels of these colitis inflammatory factors. Therefore, lychee pulp polyphenol extract has the effect of improving colitis, and it is related to the dose of litchi pulp polyphenol ex...

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Abstract

The invention discloses an application of a litchi pulp polyphenol extract in preparation of a preparation for improving ulcerative colitis. The litchi pulp polyphenol extract provided by the invention can effectively improve the change of physiological indexes caused by colitis, inhibits the increase of colitis inflammatory factor content, and has a certain improvement or regulation effect on colitis inflammation-related enzyme activity and NO release; and the polyphenol extract has the advantages of simple operation process, safety, high efficiency, recyclability and industrial production, and has great social and economic values.

Description

technical field [0001] The natural product application field of the present invention specifically relates to the application of litchi pulp polyphenol extract in preparing preparations for improving ulcerative colitis. Background technique [0002] Ulcerative colitis (UC) is the most common inflammatory bowel disease. Because ulcerative colitis has the characteristics of wide range of lesions and easy recurrence of the disease, it is difficult to understand its pathogenesis, so its treatment is relatively difficult. In modern medicine, ulcerative colitis is treated mainly by 5-aminosalicylic acid, steroid hormones, and immunosuppressants. However, 5-aminosalicylic acid is a non-specific anti-inflammatory drug, which can only temporarily control and relieve symptoms of ulcerative colitis, but cannot fundamentally treat the disease, and headache, kidney disease, and kidney disease will occur after taking the drug. Toxicity and other toxic and side effects, the condition is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/77A61P1/00A61P1/04A23L33/105A61K131/00
CPCA23V2002/00A61K36/77A61K2236/31A61K2236/39A61K2236/51A61K2236/55A23L33/105A61P1/00A61P1/04A23V2250/2132
Inventor 苏东晓黄贞贞曾庆祝袁杨何山
Owner GUANGZHOU UNIVERSITY
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