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Formula of quick-disintegrating NCP premix and preparation method thereof

A manufacturing method and premix technology, applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of affecting drug efficacy, affecting the effective release of drug ingredients, and unfavorable NCP treatment, etc. problems, to achieve the effect of convenient drug use, improved drug efficacy, and high bioavailability

Inactive Publication Date: 2020-08-04
常州灵塑科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The coating on the outside of the common NCP premix is ​​made of special materials, resulting in the coating not being able to disintegrate quickly after reaching the intestinal tract, affecting the effective release of the drug ingredients, thereby affecting its efficacy, and causing the biological degradation of the drug. The utilization is low, which is not conducive to the treatment of NCP. For the convenience of patients, especially the elderly and children who have dysphagia or patients in special circumstances, we propose a formula of fast-disintegrating NCP premix and its manufacturing method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The invention provides a technical solution: a formula of a fast-disintegrating NCP premix and a manufacturing method thereof, the raw materials of which are as follows in parts by weight: 8 parts of ribavirin ordinary tablets, 28 parts of mannitol, povidone 4 parts, lactose 12 parts, crospovidone 6 parts, low-substituted hydroxypropyl cellulose 4 parts, microcrystalline cellulose 16 parts, hydroxymethyl starch sodium 4 parts.

[0017] A kind of manufacture method of fast disintegrating type NCP premix specifically comprises the following steps:

[0018] S1. Milling: pass ribavirin ordinary tablets, mannitol, povidone, lactose, crospovidone, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, and hydroxymethyl starch sodium through 100 meshes respectively Sieve to make fine powder for later use;

[0019] S2, mixing: mix ribavirin ordinary tablet powder and auxiliary material powder evenly, add binder, binder is 75% ethanol in S2, obtain mixture A;

[...

Embodiment 2

[0023] The invention provides a technical solution: a formula of a fast-disintegrating NCP premix and a manufacturing method thereof, the raw materials of which are as follows in parts by weight: 10 parts of ribavirin ordinary tablets, 30 parts of mannitol, povidone 6 parts, lactose 14 parts, crospovidone 8 parts, low-substituted hydroxypropyl cellulose 6 parts, microcrystalline cellulose 18 parts, hydroxymethyl starch sodium 6 parts.

[0024] A kind of manufacture method of fast disintegrating type NCP premix specifically comprises the following steps:

[0025] S1. Milling: pass ribavirin ordinary tablets, mannitol, povidone, lactose, crospovidone, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, and hydroxymethyl starch sodium through 100 meshes respectively Sieve to make fine powder for later use;

[0026] S2, mixing: mix ribavirin ordinary tablet powder and auxiliary material powder evenly, add binder, binder is 75% ethanol in S2, obtain mixture A;

...

Embodiment 3

[0030] The invention provides a technical solution: a formula of fast-disintegrating NCP premix and its manufacturing method, the raw materials of which are as follows in parts by weight: 12 parts of ribavirin ordinary tablets, 32 parts of mannitol, povidone 8 parts, lactose 16 parts, crospovidone 10 parts, low-substituted hydroxypropyl cellulose 8 parts, microcrystalline cellulose 20 parts, hydroxymethyl starch sodium 8 parts.

[0031] A kind of manufacture method of fast disintegrating type NCP premix specifically comprises the following steps:

[0032] S1. Milling: pass ribavirin ordinary tablets, mannitol, povidone, lactose, crospovidone, low-substituted hydroxypropyl cellulose, microcrystalline cellulose, and hydroxymethyl starch sodium through 100 meshes respectively Sieve to make fine powder for later use;

[0033] S2, mixing: mix ribavirin ordinary tablet powder and auxiliary material powder evenly, add binder, binder is 75% ethanol in S2, obtain mixture A;

[0034] ...

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PUM

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Abstract

The invention discloses a formula of a quick-disintegrating NCP premix and a preparation method thereof. The quick-disintegrating NCP premix is prepared from 8-12 parts of ribavirin common tablets, 28-32 parts of mannitol, 4-8 parts of povidone, 12-16 parts of lactose, 6-10 parts of polyvinylpolypyrrolidone, 4-8 parts of low-substituted hydroxypropyl cellulose, 16-20 parts of microcrystalline cellulose and 4-8 parts of carboxymethyl starch sodium. According to the formula, a proper rapid disintegrating agent is selected; a tablet prepared from the magnesium stearate has certain hardness; certain looseness is realized; water is not needed to assist swallowing when the medicine is taken; the composition can be quickly disintegrated into fine particles in an oral cavity in a short time; the taking process can be completed by only several swallowing actions without influencing the effective release of medicine components, so that the medicine effect of the medicine is improved, the bioavailability of the medicine is relatively high, the NCP is favorably treated, the medicine is convenient for patients to take, especially for old people and children who have difficulty in swallowing ortake medicine in special environments, and great convenience is brought to the patients.

Description

technical field [0001] The present invention relates to the technical field of NCP premix, in particular to a formulation of fast disintegrating NCP premix and a manufacturing method thereof. Background technique [0002] NCP refers to Novel Coronavirus Pneumonia, and premix refers to a powder or granular preparation made by uniformly mixing a drug with a suitable matrix. The coating on the outside of the common NCP premix is ​​made of special materials, resulting in the coating not being able to disintegrate quickly after reaching the intestinal tract, affecting the effective release of the drug ingredients, thereby affecting its efficacy, and causing the biological degradation of the drug. The low availability is not conducive to the treatment of NCP. For the convenience of patients, especially the elderly and children who have dysphagia or patients in special circumstances, we propose a formulation of a fast-disintegrating NCP premix and its manufacturing method. Conten...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/38A61K47/26A61K47/10A61K47/32A61K47/36A61K31/7056A61P31/14A61P11/00A61P29/00A61P11/14
CPCA61K9/0056A61K9/2018A61K9/2027A61K9/2054A61K9/2059A61K9/2095A61K31/7056A61P11/00A61P11/14A61P29/00A61P31/14
Inventor 蒋晓渝蒋晓冰毛丽勤
Owner 常州灵塑科技发展有限公司