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Self-healing multi-bridging network chitosan derivatization hydrogel and preparation method thereof

A chitosan and hydrogel technology is applied in the field of self-healing multi-bridged network chitosan derivatized hydrogel and its preparation, which can solve problems such as insufficient mechanical properties, and achieve excellent mechanical properties and good self-healing. high efficacy, biocompatibility and safety

Active Publication Date: 2020-08-04
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to solve the problem of insufficient mechanical properties of the existing chitosan derivatized hydrogel, and provide a self-healing multi-bridged network chitosan derivatized hydrogel and its preparation method

Method used

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  • Self-healing multi-bridging network chitosan derivatization hydrogel and preparation method thereof
  • Self-healing multi-bridging network chitosan derivatization hydrogel and preparation method thereof
  • Self-healing multi-bridging network chitosan derivatization hydrogel and preparation method thereof

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specific Embodiment approach 1

[0043] Embodiment 1: In this embodiment, a self-healing multi-bridged network chitosan derivatized hydrogel uses chitosan as a raw material, and first obtains O-carboxymethyl based on the etherification reaction between chloroacetic acid and chitosan Chitosan, the O-carboxymethyl chitosan carries active carboxyl groups, hydroxyl groups and amino groups at the same time; then the cyclodextrin functional unit is introduced into the O-carboxymethyl chitosan structure by free radical polymerization to obtain cyclodextrin Carboxymethyl chitosan; reusing the amidation reaction to introduce thiol into the cyclodextrin carboxymethyl chitosan structure to obtain thiolated cyclodextrin carboxymethyl chitosan, the thiolated cyclodextrin carboxymethyl chitosan The polysaccharide carries active carboxyl, sulfhydryl and cyclodextrin functional units at the same time; the ferrocene functional unit is introduced into the polyacrylamide structure to obtain polyacrylamide-ferrocene; the thiolate...

specific Embodiment approach 2

[0047] Embodiment 2: This embodiment is different from Embodiment 1 in that: the degree of deacetylation of the chitosan is 90%, and the molecular weight is 80,000-140,000. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0048] Specific embodiment three: the preparation method of a self-healing multi-bridged network chitosan derivatized hydrogel in this embodiment is specifically carried out in the following steps:

[0049] 1. Preparation of O-carboxymethyl chitosan: ①. Disperse chitosan in isopropanol, and stir for 30min to 60min, obtain the isopropanol solution of chitosan, the concentration of chitosan in the isopropanol solution of chitosan is 0.3mmol / L~1.2mmol / L; ②, divide the sodium hydroxide aqueous solution 4~6 times Add chitosan in isopropanol solution, and stir and react for 30min to 60min at a temperature of 20°C to 26°C and a rotational speed of 800r / min to 1300r / min to obtain a reaction solution I; the sodium hydroxide aqueous solution The sodium hydroxide concentration in the medium is 8mol / L~12mol / L; The volume ratio of the isopropanol solution of described sodium hydroxide aqueous solution and chitosan is 1:(3~5); ③, chloroacetic acid is dissolved in isopropyl alcohol Alcohol ...

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Abstract

The invention discloses a self-healing multi-bridging network chitosan derivatization hydrogel and a preparation method thereof, which relates to a multi-bridging network hydrogel and a preparation method thereof. The invention aims to solve the problem that the mechanical property and the self-healing property of the existing natural polysaccharide hydrogel cannot be obtained at the same time. The chitosan is used as a raw material, carboxyl, cyclodextrin and sulfydryl are introduced into the chitosan through carboxylation, free radical polymerization and amidation, and the multi-bridging network hydrogel is obtained through host-guest coordination between the cyclodextrin and ferrocene, disulfide bonds between double sulfydryls and hydrogen bonds between hydroxyl oxygen and hydrogen. Themethod comprises the following steps: 1, preparing O-carboxymethyl chitosan; 2, preparing vinyl-cyclodextrin-itaconic acid ester; 3, preparing cyclodextrin carboxymethyl chitosan; 4, preparing thiolated cyclodextrin carboxymethyl chitosan; 5, preparing polyacrylamide ferrocene; and 6, preparing the hydrogel material. The preparation method has the advantages that the elasticity modulus of the hydrogel reaches 1500KPa, and the mechanical property is reduced by 80% after self-healing. The self-healing multi-bridging network chitosan derivatization hydrogel is used as a high-strength self-healing hydrogel material.

Description

technical field [0001] The invention relates to a self-healing multi-bridge network chitosan derivatized hydrogel and a preparation method thereof. Background technique [0002] The integrity of body tissue is one of the indispensable and important symbols of human health. However, due to the variety of injury inducements and complex forms of injury, the actual speed and degree of tissue damage generally far exceed its self-healing ability, and patients suffering from this may face permanent damage. The damage is irreparable and ultimately seriously affects the quality of life. Natural polysaccharide-based hydrogels have a high similarity to the texture and possible functions of biological tissues in the body, and are suitable as ideal tissue engineering replacement materials. A series of deficiencies in the application of replacement related fields, such as the basic properties of materials such as special strength and toughness, the synergy of composite functional propert...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L33/26C08L87/00C08G81/00C08B37/16C08B37/08C08F8/42C08F120/56
CPCC08J3/075C08G81/00C08B37/0012C08B37/003C08F8/42C08J2333/26C08J2387/00C08F120/56
Inventor 王路王笑李书彬刘延浩
Owner HARBIN INST OF TECH
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