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Continuous nitration reaction system and continuous nitration process of methyl benzoic acid

A technology of toluic acid and nitrification system, applied in the field of continuous nitrification process, can solve the problems of low production efficiency, high energy consumption, complicated operation and the like

Pending Publication Date: 2020-08-07
山东友道化学有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to solve this problem in the batch production process, nitric acid is added dropwise or toluic acid is slowly fed, and the reactor will increase the heat exchange area by adding a heat exchange structure to ensure that the flow rate of the refrigerant is relatively large. Under normal circumstances, the heat generated by the nitration reaction of methyl benzoic acid can be removed in time to achieve a benign control effect. Therefore, the batch kettle process is cumbersome to operate, high in energy consumption, and low in production efficiency.

Method used

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  • Continuous nitration reaction system and continuous nitration process of methyl benzoic acid
  • Continuous nitration reaction system and continuous nitration process of methyl benzoic acid
  • Continuous nitration reaction system and continuous nitration process of methyl benzoic acid

Examples

Experimental program
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Effect test

Embodiment 1

[0095] The outlet of the solid continuous feeding system (2) is connected with the first material inlet of the continuous nitration reactor (1), the outlet of the liquid continuous feeding system (3) is connected with the material inlet of the liquid cooler (4), and the liquid cooler (4) ) is connected to the second material inlet of the continuous nitration reactor (1), the material outlet of the continuous nitration reactor (1) is connected to the inlet of the reaction solution thickener (5), and the reaction solution thickener (5) The outlet of the clear liquid is connected with the material inlet of the circulating liquid condenser (6), the material outlet of the circulating liquid condenser (6) is connected with the third material inlet of the continuous nitration reactor (1), and the refrigerant outlet of the refrigerant system (7) It is connected with the refrigerant inlet of the continuous nitration reactor (1), and the refrigerant return port of the refrigerant system ...

Embodiment 2

[0101] The difference between embodiment 2 and embodiment 1 is that the continuous nitration reactor (1) selected is a tubular reactor with a rod-shaped stirring structure with a volume of 100 L, and the connection mode of the equipment and the inlet position of the material are all the same as in embodiment 1.

[0102] Use the continuous nitration reaction system of toluic acid to carry out the continuous nitration reaction of o-toluic acid:

[0103] The o-toluic acid is continuously transported at a flow rate of 150kg / h through the solid continuous feeding system (2), and enters the continuous nitration reactor (1) from the first material inlet, and at the same time, the nitric acid with a concentration of 98% is continuously fed from the liquid The system (3) conveys the continuous flow through the liquid raw material cooler (4) to be precooled to 18°C ​​lower than the reaction temperature, i.e. -30°C, and enters the continuous nitration reactor (1) from the second material ...

Embodiment 3

[0106] The difference between embodiment 3 and embodiment 1 is that the continuous nitration reactor (1) selected is a tubular reactor with a plug-in mixing structure with a volume of 100 L, and the connection mode of the equipment and the inlet position of the material are all the same as those in embodiment 1. same.

[0107] Use the continuous nitration reaction system of toluic acid to carry out the continuous nitration reaction of p-toluic acid:

[0108] P-benzoic acid is continuously transported at a flow rate of 140kg / h through the solid continuous feeding system (2), and enters the continuous nitration reactor (1) from the first material inlet, and simultaneously the nitric acid with a concentration of 98% is fed from the liquid continuous feeding system (3) Convey and flow through the liquid raw material cooler (4) to be pre-cooled to 20 ℃ lower than the reaction temperature, i.e. -30 ℃, enter the continuous nitration reactor (1) by the second material inlet, the quali...

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Abstract

The invention provides a continuous nitrification system and the continuous nitrification process of methyl benzoic acid. The continuous nitrification reaction of methyl benzoic acid is realized by utilizing a continuous reaction system; on the one hand, the heat exchange efficiency is improved due to reduction of the reaction volume, and the energy utilization rate is higher; on the other hand, the dilute phase liquid separated by a reaction liquid thickener is added into the continuous nitrification reactor, so that the nitric acid is fully utilized, the cooling capacity of the dilute phaseliquid is also fully utilized, the workload of a refrigerant system is greatly reduced, and the energy waste is reduced while the dosage of the nitric acid is reduced. Meanwhile, by matching the improvement of process conditions, the continuous and rapid implementation of the nitration reaction of methyl benzoic acid is ensured, and the production efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of chemical industry, in particular to a continuous nitration reaction system and continuous nitration process of methyl benzoic acid. Background technique [0002] There are three isomers of toluic acid, m-toluic acid, o-toluic acid and p-toluic acid. The nitrated products obtained after the nitration reaction of m-toluic acid have three isomers, namely 2-nitro-3-methylbenzoic acid, 3-methyl-4-nitrobenzoic acid, 2-nitro -5-Methylbenzoic acid, these three isomeric products are all important intermediates in the field of medicine and pesticides, among which 2-nitro-3-methylbenzoic acid is a highly effective compound for the synthesis of chlorantraniliprole and cyantraniliprole, etc. The key intermediate of low-toxic pesticides, 3-methyl-4-nitrobenzoic acid is an important intermediate for the synthesis of telmisartan and other medicines, 2-nitro-5-methylbenzoic acid is a synthetic pyrimidine anticancer drug ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J19/00B01J19/18B01J19/24B01J4/00C07C201/08C07C205/57
CPCB01J4/001B01J19/0013B01J19/1812B01J19/1881B01J19/2415B01J19/2465B01J2204/002B01J2219/00033B01J2219/00074C07C201/08C07C205/57
Inventor 张本松王远超张海波赵平唐立星焦玉坤郑浩
Owner 山东友道化学有限公司
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