PLA/CA/PAMAM dendrimer blend and preparation method thereof

A technology of dendrimers and blends, applied in the direction of resisting vector-borne diseases, etc., can solve the problems of poor compatibility between PLA and CA

Active Publication Date: 2020-08-07
BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, current studies have found that the compatibility between PLA and CA is poor, so solving the compatibility between the two is the goal we are pursuing.

Method used

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  • PLA/CA/PAMAM dendrimer blend and preparation method thereof
  • PLA/CA/PAMAM dendrimer blend and preparation method thereof
  • PLA/CA/PAMAM dendrimer blend and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1 Preparation of G5.5 generation PAMAM dendrimers terminated with ester groups

[0054] Synthesis of PAMAM dendrimers:

[0055] (1) Take 68.8g of methyl acrylate after vacuum distillation in a 250mL round bottom flask, add 100mL of methanol to dissolve; add 6g of ethylenediamine dropwise at a rate of 2 drops / s, and react at 35°C for 6h; Then at 50° C., excess methyl acrylate and reaction solvent methanol were removed under 0.1 mmHg vacuum to obtain PAMAM dendrimers terminated by ester groups in the G0.5 generation;

[0056] (2) Get 240g of ethylenediamine in a 500mL round-bottomed flask, add 100mL of methanol to dissolve it, and set aside; take 20.2g of PAMAM dendrimers terminated with ester groups on behalf of G0.5 and add 100mL of methanol to dissolve it, and dissolve the obtained solution with Add dropwise at a speed of 2 drops / s to the previous methanol solution of ethylenediamine, react at 50°C for 24 hours; then remove excess ethylenediamine and reaction ...

Embodiment 2

[0061] Example 2 Preparation of G4.5 generation PAMAM dendrimers terminated with ester groups

[0062] Synthesis of PAMAM dendrimers:

[0063] (1) Take 63.5g of methyl acrylate after vacuum distillation in a 250mL round bottom flask, add 100mL of methanol to dissolve; add 6g of ethylenediamine dropwise at a rate of 2 drops / s, and react at 30°C for 7h; Then at 50° C., excess methyl acrylate and reaction solvent methanol were removed under 0.1 mmHg vacuum to obtain PAMAM dendrimers terminated by ester groups in the G0.5 generation;

[0064] (2) Get 225g of ethylenediamine in a 500mL round-bottomed flask, add 100mL of methanol to dissolve it, and set aside; take 20.2g of PAMAM dendrimers terminated with ester groups on behalf of G0.5 and add 100mL of methanol to dissolve it, and the obtained solution is Add dropwise at a speed of 2 drops / s to the previous methanol solution of ethylenediamine, react at 40°C for 28 hours; then remove excess ethylenediamine and reaction solvent met...

Embodiment 3

[0068] Example 3 Preparation of G3.5 generation PAMAM dendrimers terminated with ester groups

[0069] Synthesis of PAMAM dendrimers:

[0070] (1) Take 70.2g of methyl acrylate after vacuum distillation in a 250mL round bottom flask, add 100mL of methanol to dissolve; add 6g of ethylenediamine dropwise at a rate of 2 drops / s, and react at 40°C for 5h; Then at 50° C., excess methyl acrylate and reaction solvent methanol were removed under 0.1 mmHg vacuum to obtain PAMAM dendrimers terminated by ester groups in the G0.5 generation;

[0071] (2) Get 250g of ethylenediamine in a 500mL round-bottomed flask, add 100mL of methanol to dissolve it, and set it aside; take 20.2g of PAMAM dendrimer terminated with ester groups on behalf of G0.5 and add 100mL of methanol to dissolve it, and dissolve the obtained solution with Add dropwise at a speed of 2 drops / s to the previous methanol solution of ethylenediamine, and react at 60°C for 20 hours; then at 65°C, remove excess ethylenediamin...

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Abstract

The invention discloses a PLA/CA/PAMAM dendrimer blend and a preparation method thereof. According to the preparation method, PLA, CA and PAMAM dendrimers are subjected to solution blending so as to obtain the PLA/CA/PAMAM dendrimer blend. A preparation method of the PAMAM dendrimers comprises the following steps: carrying out an addition reaction on ethylenediamine and methyl acrylate to obtain ester group-terminated G-0.5 PAMAM dendrimers; carrying out an amidation reaction on the G-0.5 PAMAM dendrimer and ethanediamine to obtain G-1.0 PAMAM dendrimers which are terminated by amino groups; and repeating the addition reaction and the amidation reaction to synthesize the PAMAM dendrimers with different end group types and different generations. According to the invention, the PAMAM dendrimers are adopted for compatibilization modification of the compatibility of PLA and CA, the compatibility of the prepared PLA/CA/PAMAM dendrimer blend is better, and the strength and toughness of the prepared PLA/CA/PAMAM dendrimer blend are also improved.

Description

technical field [0001] The invention relates to the field of polymer materials, in particular to a PLA / CA / PAMAM dendrimer blend and a preparation method thereof. Background technique [0002] Polylactic acid (PLA) is a thermoplastic aliphatic polyester that can be derived from microbial fermentation of biomass feedstocks (cassava, sugar beet, sugar cane, etc.). PLA has many fascinating properties, such as good biodegradability, biocompatibility, and tensile strength. However, due to the existence of a semi-rigid structure in the molecular chain segments, the molecular chain flexibility of PLA is poor. Therefore, the entanglement between molecules is greatly restricted, and PLA exhibits obvious brittleness at room temperature, which greatly limits the application of PLA. In order to overcome these shortcomings of PLA, research on the modification of PLA is needed. Blending PLA with other bio-based degradable materials (such as PHBV, PBS, cellulose, etc.) is an important mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L67/04C08L1/12C08L73/02C08J5/18C08G73/02
CPCC08J5/18C08G73/028C08J2367/04C08J2401/12C08J2473/02Y02A50/30
Inventor 靳玉娟汪博翁云宣孙健健
Owner BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY
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