Cerebral perfusion weighted imaging method based on arterial spin labeling and variable delay time

Abstract

The invention discloses a cerebral perfusion weighted imaging method based on artery spin labeling and variable delay time, wherein the method comprises the steps: applying 180-degree pulses to a marked area, and acquiring signals on an imaging layer by adopting a rapid sequence after t time to obtain an image signal scanned for the first time; applying 180-degree pulses to the marked area, aftert+(n-1)*m time, collecting signals on the imaging layer in a rapid sequence mode, and thus obtaining image signals scanned for the n time, wherein n is greater than or equal to 3; constructing animage signal intensity-time curve according to the n scanned image signals; and calculating the image signal intensity-time curve to obtain cerebral perfusion parameters. According to the method, twice scanning of marking and unmarking is not needed, so that the sensitivity to motion is reduced; the radio frequency energy deposition is small; brain perfusion parameters such as blood volume, bloodflow, average transfer time and arrival time can be generated.

Description

Technical field [0001] The present invention relates to the field of magnetic resonance sequence, in particular to a cerebral perfusion weighted imaging method based on arterial spin labeling with variable delay time. Background technique [0002] Magnetic resonance perfusion weighted imaging uses endogenous or exogenous contrast agents to measure a series of parameters such as blood flow and blood volume in the capillary bed in normal or diseased tissues. Exogenous contrast agents are generally paramagnetic contrast agents commonly used in magnetic resonance, such as gadolinium-based contrast agents, which can shorten blood t2 and t2 in the blood * Time, leading to the time between t2 and t2 * The signal of capillary blood vessels and adjacent tissues on the weighted image will be reduced, and the degree of signal reduction is proportional to the content of the intravascular contrast agent, so that the blood volume and blood flow in the unit volume of tissue can be calculated. [...

AI Technical Summary

Problems solved by technology

[0004] In view of the above deficiencies in the prior art, the purpose of the present invention is to provide a brain perfusion weighted imaging method based on arterial spin labeling with variable delay time, aiming to solve the existing arterial spin labeling technology based on endogenous contrast agent Only cerebral blood flow parameters can be obtained, and its radio frequency energy is relatively high, and it is very sensitive to exercise

Images