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A kind of external preparation of nitroglycerin

A technology of nitroglycerin and nitroglycerin dichloromethane, applied in the direction of medical preparations of non-active ingredients, aerosol delivery, non-active ingredients of oil/fat/wax, etc.

Active Publication Date: 2022-07-19
北生星晟科技发展(启东)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This hazardous property is the most important obstacle to the production of nitroglycerin

Method used

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  • A kind of external preparation of nitroglycerin
  • A kind of external preparation of nitroglycerin
  • A kind of external preparation of nitroglycerin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0079] An external preparation of nitroglycerin, characterized in that: the concentrated sulfuric acid and fuming nitric acid are mixed at a rate of 1:1 by a microreactor chip (1); glycerol and dichloromethane are input into the mixing at a rate of 0.2:2 (2), the mixed acid solution of the microreactor chip (1) and the solution of the mixer (2) are input into the microreactor chips (3), (4), (5) at a speed ratio of 2:2.75, The retention time of the reaction solution in the microreactor is 10min to 30min, the reaction solution is input from the microreactor (5) to the Zaiput liquid-liquid separator (6), the acid solution is input to the waste liquid processor, and the organic phase is mixed with water to the input After the device (7) is mixed, it is input to the Zaiput liquid-liquid separator (8), the water phase is input to the waste liquid processor, the organic phase and the saturated salt solution are input to the Zaiput liquid-liquid separator (9), and the water phase is i...

Embodiment 2

[0081] Green granules of nitroglycerin

[0082] A 10% concentration nitroglycerin dichloromethane solution (10 ml) was pumped into a hot melt extruder, 9 grams of lactose granules were added, granulated by wet granulation mode, and vacuum dried to obtain green nitroglycerin granules.

Embodiment 3

[0084] Green lyophilized granules of nitroglycerin (1)

[0085] 20 ml of 10% nitroglycerin dichloromethane solution, 5 g of polyvinylpyrrolidone, and 18 g of lactose; add an appropriate amount of water for injection, slowly add 0% nitroglycerin dichloromethane solution, polyvinylpyrrolidone, and lactose, and stir while adding After complete mixing, the package is stirred for about 2-4 hours; vacuum freeze-dried to obtain green freeze-dried particles of nitroglycerin (1).

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Abstract

The invention relates to an external preparation of nitroglycerin, which realizes the integrated production of API and the external preparation of nitroglycerin, improves safety, reduces impurity content, is conducive to environmental protection and reduces waste discharge.

Description

technical field [0001] The invention belongs to the field of medicaments, in particular to an external preparation of nitroglycerin. Background technique [0002] Angina pectoris is a clinical syndrome mainly manifested by episodic chest pain or chest discomfort caused by insufficient coronary blood supply and acute myocardial ischemia and hypoxia. Nitroglycerin can directly relax vascular smooth muscle, especially small vascular smooth muscle, which can dilate peripheral blood vessels, reduce peripheral resistance, reduce blood return to the heart, reduce cardiac output, reduce cardiac load, reduce myocardial oxygen consumption, and thus relieve angina pectoris. Nitroglycerin can promote the formation of collateral circulation. Take 1 tablet under the tongue, it will take effect in 2 to 3 minutes, and the effect will last for about 30 minutes. [0003] Nitroglycerin, also known as glycerol trinitrate, is produced by the nitration of glycerol. The reaction equation is as ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K9/16A61K9/70A61K9/00A61K9/12A61K9/06A61K31/21A61P9/10A61P11/02A61P1/00A61P15/08A61P15/10G01N33/02
CPCA61K9/08A61K9/1623A61K9/1635A61K9/1652A61K9/7023A61K47/38A61K9/0014A61K9/0019A61K47/26A61K9/12A61K9/06A61K47/44A61K47/28A61K31/21A61P9/10A61P11/02A61P1/00A61P15/08A61P15/10G01N33/02G01N2030/027
Inventor 张志祥
Owner 北生星晟科技发展(启东)有限公司
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