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First-aid dressing for large-area wound and preparation method thereof

A large-area, traumatic technology, applied in the field of large-area wound first aid dressing and its preparation, can solve the problems of secondary wound injury, skin irritation, poor bacteriostatic effect of the dressing, and achieve good biocompatibility and restore vascular function. , the effect of high hemostatic efficiency

Pending Publication Date: 2020-08-28
YIGONG RUISI FUJIAN ENG RES CENT CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Experiments have shown that: among them, the content of chitosan is less than 2%, and the antibacterial effect of the dressing is poor, which is not conducive to the growth of wounds.
[0007] Patent CN106334209A discloses a polydopamine-modified chitosan hemostatic dressing, which contains chitosan, polydopamine and at least one calcium salt. The tissue viscosity of this material is too high, which will cause secondary damage to the wound when the dressing is changed, and Polydopamine solution is obtained by adjusting the pH of dopamine hydrochloride to alkaline. Alkaline solution will be irritating to the skin and affect the healing of the bleeding site

Method used

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  • First-aid dressing for large-area wound and preparation method thereof
  • First-aid dressing for large-area wound and preparation method thereof
  • First-aid dressing for large-area wound and preparation method thereof

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Embodiment approach 1

[0034] The invention provides a first-aid dressing for large-area wounds, which comprises the following components: modified chitosan, biomass protein fibers and polyphenol compounds.

[0035] In the present invention, the modified chitosan with good biocompatibility, biomass protein fiber and polyphenolic compound are selected as the main raw materials, and obtained through self-assembly and compound synergy under the realization of wet environment (comprising water, PBS buffering) Liquid, blood environment) fast-adhesive and antibacterial new hemostatic materials.

[0036] Among them, modified chitosan, such as: dodecylated chitosan is a kind of natural mucopolysaccharide, which has good biocompatibility, its cationic effect and the characteristics of three-dimensional molecular network structure in blood, which can Quickly capture and activate red blood cells and platelets to form blood clots. Furthermore, modified chitosan, such as: the segment of dodecylated chitosan mol...

Embodiment approach 2

[0057] This embodiment provides a method for preparing a first-aid dressing for large-area wounds, which includes the following steps: adding a biomass protein fiber solution and a polyphenol compound solution to the modified chitosan solution and mixing them uniformly to obtain the dressing.

[0058] In the modified chitosan solution, it is preferable to add the biomass protein fiber solution and the polyphenolic compound solution successively, and after adding the polyphenolic compound solution, silver alginate can also be added; adopting this adding method, the auxiliary material has better and More stable network structure.

[0059] Wherein, the mixing speed is 0.01-1L / min, and stirring is carried out during the mixing.

[0060] Wherein, in the modified chitosan solution, the concentration of the modified chitosan is 0.001~10g / mL; the modified chitosan solution is preferably a dodecylated chitosan solution, and its preparation method is:

[0061] Dissolve chitosan in acet...

Embodiment 1

[0069] The large-area wound emergency dressing is prepared from dodecylated chitosan, silk fibroin, keratin and tannic acid in a mass ratio of 1000:1:1:1000.

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Abstract

The invention belongs to the field of biomaterial preparation and biomedical application, and particularly relates to a first-aid dressing for large-area wound and a preparation method thereof. The first-aid dressing comprises the following components: modified chitosan, biomass protein fibers and a polyphenol compound. The dressing is prepared by uniformly mixing the modified chitosan, the biomass protein fibers and the polyphenol compound at room temperature. The dressing prepared by the invention is high in hemostatic efficiency, high in bonding speed, wide in application range, strong in targeted antibacterial property, safe, non-toxic, good in biocompatibility and convenient to operate in a wet environment. The dressing is wide in raw material source, can be used for hemostasis and healing repair of various wound surfaces, is expected to replace traditional medical adhesives, and has a wide clinical application prospect.

Description

technical field [0001] The invention belongs to the fields of biological material preparation and biomedical application, and in particular relates to a first-aid dressing for large-area wounds and a preparation method thereof. Background technique [0002] Over the years, the first aid treatment for sudden accidents in daily life, the doctor’s wound hemostasis during the operation of the patient, and the rescue and hemostasis of the wounded soldiers in the war are mostly through physical oppression, such as bandages, gauze, rubber strips, etc., but The effect is limited. In clinical medicine, the demand for bandaging and hemostasis in the whole chain of the rescue ladder, especially for acute severe bleeding of wounds in emergencies, due to the variety of wet states and dynamic complexity of the sudden bleeding environment, currently available hemostatic products cannot meet the requirements. Rapid and effective hemostasis can also have an antibacterial effect, and hemorrh...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/32A61L15/44
CPCA61L15/28A61L15/32A61L15/44A61L2300/104A61L2300/252A61L2300/402A61L2300/404A61L2400/04C08L5/08
Inventor 张进林哲
Owner YIGONG RUISI FUJIAN ENG RES CENT CO LTD
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