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Emulsified inhalational anaesthetic for intravenous injection and its preparation

An anesthetic and systemic technology, applied in the directions of anesthesia, drug combination, emulsion delivery, etc., can solve the problems of difficulty in adjusting the depth of general anesthesia, increasing the cost of general anesthesia, and the impact of human liver and kidney function, etc. Residual capacity of pulmonary function and the effect of adjusting the depth of general anesthesia

Inactive Publication Date: 2003-07-30
刘进 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing inhaled general anesthetics need to be used through a special anesthesia machine and equipped with an inhaled general anesthetic volatilizer. The cost of anesthesia and medical expenses are high, and due to the influence of the breathing circuit and lung function residual capacity, the controllability of inhalation general anesthesia is poor, the induction speed is slow, and the amount of inhalation general anesthesia is insufficient; the existing intravenous systemic anesthesia Anesthetics need to circulate in the body with the veins and participate in the metabolism in the body during use. Therefore, the controllability of the existing intravenous general anesthetics is poor, and it has a greater impact on human liver and kidney functions, and it is difficult to adjust the depth of general anesthesia; As mentioned above, the existing general anesthetics need to be improved

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment one, flask method:

[0019] In this method, care should be taken to prevent gas from entering during the preparation process.

[0020] ①Take a 100ml flask, insert two needles of different lengths on the bottle cap, the long needle is close to the bottom of the bottle, and the upper part of the needle is connected to a stainless steel tee;

[0021] ② Fill the flask with 20g of refined soybean oil, 1.2g of refined lecithin, 2.25g of glycerin and 4.5g of glucose;

[0022] ③Refill with water for injection and shake well to get 100ml fat emulsion;

[0023] ④Use a glass syringe with a tee to extract the liquid inhalation anesthetic isoflurane;

[0024] ⑤Weigh with an electronic scale, weigh out 2ml of liquid isoflurane,

[0025] ⑥Add 2ml of liquid isoflurane anesthetic into the flask;

[0026] ⑦ The excess fat emulsion in the flask is discharged from the short needle;

[0027] ⑧Suck the syringe back and forth 5 to 10 times to fully dissolve the anesthetic into...

Embodiment 2

[0029] Embodiment two, latex plastic bag method:

[0030] ①Take a 200ml latex bag;

[0031] ②Put 40g of refined soybean oil, 2.4g of refined lecithin, 4.5g of glycerin and 9g of glucose into the latex bag;

[0032] ③Refill with water for injection and shake well to get 200ml fat emulsion;

[0033] ④ Add 3ml of the liquid inhalation anesthetic sevoflurane into the latex bag;

[0034] ⑤Insert a needle with a tee at the exhaust port to exhaust and discharge excess fat emulsion;

[0035] ⑥ Shake well and wait for 10 to 20 minutes to obtain 200 ml of emulsified inhalation anesthetic for intravenous injection of the present invention. Animal experiment of the present invention proves:

[0036] The emulsified inhalation anesthetic for intravenous injection of the present invention is subjected to physical and chemical property testing and animal experiments, and it is found that its performance is stable, and its general anesthesia effect is reliable and effective.

[0037] The ...

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PUM

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Abstract

Emulsified inhalational anaesthetic is compounded with fatty emulsion and inhalational anaesthetic. Its application has less pollution to air, fast and controllable anaesthesia effect, no toxic side effect and less influence to respiratory loop and pulmonary function caused by residual anaesthetic gas. It may be also used in specific case, such as extracorporeal circulation. It can be separated from lung for regulating anaesthesia depth and its use requires only less muscle relaxing medicine, so that it is one safe and effective general anaesthetic.

Description

technical field [0001] The present invention relates to an intravenous general anesthetic, that is, an emulsified inhalation anesthetic for intravenous injection and a preparation method thereof, in particular to a method in which the inhalation general anesthetic is dissolved in a fat emulsion and injected intravenously to produce general anesthesia medicine. Background technique [0002] At present, there are generally two kinds of general anesthetics used in surgery in the medical field, namely inhalation general anesthetics and intravenous general anesthetics. Inhalation general anesthetics can be subdivided into volatile general anesthetics and gaseous general anesthetics. The existing inhaled general anesthetics need to be used through a special anesthesia machine and equipped with an inhaled general anesthetic volatilizer. The cost of anesthesia and medical expenses are high, and due to the influence of the breathing circuit and lung function residual capacity, the ...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K31/08A61P23/00
Inventor 刘进宁新宇王晟
Owner 刘进
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