Full-view imaging device for pathological tissue slide

Abstract

The invention discloses a full-view imaging device for a pathological tissue slide, and the device comprises an image sensor chip, wherein a photosensitive area is arranged in the middle of the imagesensor chip, and the pathological tissue slice is directly fixed on the surface of the photosensitive area so as to record projection microscopic image data of the pathological tissue slide; the light-emitting surface of a light source device covers the photosensitive area and is used for providing illumination during pathological tissue slide imaging; a driving device is used for respectively providing driving force for the image sensor chip and the light source device; and computer equipment is used for receiving and processing the projection microscopic image data of the pathological tissueslide. Beneficial effects are as follows: the full-view imaging device is low in structural complexity; the imaging process is simple and convenient, imaging in the full-view range can be achieved while the resolution is guaranteed, the detection efficiency of pathological tissue slide is improved, the view field range only depends on the size of a photosensitive area of the image sensor chip, and one-time full-view imaging can be conducted on the pathological tissue slide under the centimeter-level and sub-centimeter-level sizes.

Description

technical field [0001] The invention relates to the technical field of optical microscopic imaging, in particular to a full-field imaging device for pathological tissue slices. Background technique [0002] Pathological examination has been widely used in clinical work and scientific research. In clinical practice, pathological examination of cadavers and surgical pathology are mainly carried out. The purpose of surgical pathological examination is, on the one hand, to clarify the diagnosis and verify the preoperative diagnosis, and improve the level of clinical diagnosis; on the other hand, after the diagnosis is confirmed, the next treatment plan can be determined and the prognosis can be estimated, thereby improving the level of clinical treatment. Through clinical and pathological analysis, a large amount of extremely valuable scientific research data can also be obtained. [0003] Pathological slices are a type of pathological specimens. Part of the diseased tissues or...

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Problems solved by technology

[0004] At present, the general diagnostic method of pathological tissue sections in the pathology department of the hospital is mainly based on observation under the optical microscope. Due to the existence of the lens system of the optical microscope, the field of view decreases sharply with the increase of the magnification. Therefore, most scenes The diameter of the field of view of the optical microscope is on the order of millimeters or submillimeters, which makes it impossible for the optical microscope to complete one-time imaging of tissue sections. In order to observe and compare different areas, medical staff must repeatedly move the field of view. At the same time, extremely high requirements are put forward for the richness of work experience of diagnostic medical staff, which also results in a shortage of resources for diagnostic doctors in the pathology department

[0005] Another method of automatic data collection is to install a high-precision mechanical scanning device under the microscope. After mechanical scanning, hundreds of microscopic images of a single small field of view are obtained by using software algorithms to stitch together a full field of view. Microscopic images of pathological slices, this method not only increases the cost of high-precision hardware and is time-consuming, but also causes uneven slices due to differences in the level of different slicers, resulting in changes in the clear focus of the microscope, which further leads to complete stitching Field of view image is inaccurate or out of focus

At the same time, stitching by algorithms is prone to distortion and distortion of image information at the stitching between small fields of view

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