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Sodium alginate swollen microneedle patch and preparation method thereof

A technology of sodium alginate and microneedle paste, which is applied in the direction of microneedles, needles, and pharmaceutical formulations, and can solve the problem of continuous limitation of diffusion channels for large-dose administration, poor biocompatibility of human protein, and the impact of embedded protein properties, etc. problems, to achieve excellent physiological inertia, excellent biocompatibility, and protect the effect of protein activity

Pending Publication Date: 2020-09-04
无锡元旭生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies of the above-mentioned prior art, the present invention provides a sodium alginate swollen microneedle patch, the purpose of which is to solve the problem of poor biocompatibility with human protein in the existing microneedle preparation materials for embedding proteins, large-dose administration and diffusion channels. The sustainability of the product is limited, and the technical problem that the preparation conditions are severe will affect the properties of the embedded protein

Method used

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  • Sodium alginate swollen microneedle patch and preparation method thereof
  • Sodium alginate swollen microneedle patch and preparation method thereof
  • Sodium alginate swollen microneedle patch and preparation method thereof

Examples

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Embodiment 1

[0025] The sodium alginate swelling microneedle patch provided in this embodiment has a specific technical scheme as follows:

[0026] Sodium alginate swollen microneedle patches, such as figure 2 As shown, it includes a needle body and a microneedle substrate, and the needle body array is distributed on the microneedle substrate and integrally formed with the microneedle substrate. The needle body includes sodium alginate and polyvinylpyrrolidone, and the composition ratio is 6:1 in terms of weight percentage. The pitch of the needles is 600 μm, and the vertical height of the needles is 200 μm. The needle body is a tapered structure, and the taper of the needle body is 70°.

[0027] This embodiment provides the above-mentioned method for swelling the microneedle patch with sodium alginate, comprising the following steps:

[0028] S1, using silicon microneedles with a height of 200 μm and a needle spacing of 600 μm as a mold, pouring a mixture of polydimethylsiloxane and c...

Embodiment 2

[0033] The sodium alginate swelling microneedle patch provided in this embodiment has a specific technical scheme as follows:

[0034] Sodium alginate swollen microneedle patches, such as image 3 As shown, it includes a needle body and a microneedle substrate, and the needle body array is distributed on the microneedle substrate and integrally formed with the microneedle substrate. The needle body includes sodium alginate and polyvinylpyrrolidone, and the composition ratio is 6:1 in terms of weight percentage. The pitch of the needles is 800 μm, and the vertical height of the needles is 450 μm. The needle body is a tapered structure, and the taper of the needle body is 80°.

[0035] This embodiment provides the above-mentioned method for swelling the microneedle patch with sodium alginate, comprising the following steps:

[0036] S1, using silicon microneedles with a height of 450 μm and a needle spacing of 800 μm as a mold, pouring a mixture of polydimethylsiloxane and cu...

Embodiment 3

[0041] The sodium alginate swelling microneedle patch provided in this embodiment has a specific technical scheme as follows:

[0042] The sodium alginate swollen microneedle patch includes a needle body and a microneedle substrate, and the needle body array is distributed on the microneedle substrate and integrally formed with the microneedle substrate. The needle body includes sodium alginate and polyvinylpyrrolidone, and the composition ratio is 5:1 in terms of weight percentage. The pitch of the needles is 700 μm, and the vertical height of the needles is 800 μm. The needle body is a tapered structure, and the taper of the needle body is 70°.

[0043] This embodiment provides the above-mentioned method for swelling the microneedle patch with sodium alginate, comprising the following steps:

[0044]S1, using silicon microneedles with a height of 800 μm and a needle spacing of 700 μm as a mold, pouring a mixture of polydimethylsiloxane and curing agent at a ratio of 10:1, ...

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Abstract

The invention belongs to the technical field of fine processing, and particularly relates to a sodium alginate swollen microneedle patch. The patch comprises a needle body and a microneedle substrate,wherein the needle body comprises sodium alginate and polyvinylpyrrolidone, and the weight percentage ratio of the sodium alginate to the polyvinylpyrrolidone is (4-6): 1. The sodium alginate swollenmicroneedle patch provided by the invention adopts the sodium alginate and the polyvinylpyrrolidone as embedding vectors of protein drugs, so that the microneedle patch has good biocompatibility, maintains a continuous drug diffusion channel, allows large-dose drug delivery, and can control drug release as required. Besides, the preparation method of the sodium alginate swollen microneedle patchprovided by the invention is simple in preparation process and mild in condition, avoids high temperature and other harmful conditions, and is beneficial to protection of protein activity.

Description

technical field [0001] The invention belongs to the technical field of fine processing, and in particular relates to a sodium alginate swelling microneedle patch and a preparation method thereof. Background technique [0002] With the development of biotechnology, protein and polypeptide drugs have been continuously developed. Since these drugs are easily degraded in the gastrointestinal tract when taken orally, the sustained and controlled release preparations of polypeptide / protein drugs have attracted widespread attention in recent years. Because microneedle technology can directly break through the barrier of the stratum corneum of the skin, it can significantly promote the transdermal absorption of various drug molecules, including proteins / polypeptides and drug-loaded nanoparticles. Microneedle technology is a brand-new drug delivery technology that combines the advantages of injection and transdermal patch, so it has become the most promising new technology for transd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/36A61K47/32A61K38/00A61M37/00
CPCA61K9/0021A61K47/36A61K47/32A61K38/00A61M37/0015A61M2037/0046A61M2037/0053
Inventor 赵科研杨淑艳郭文平
Owner 无锡元旭生物技术有限公司