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A device for regulating red blood cells in the blood vessels of living animals

A red blood cell, animal technology, applied in biological testing, treatment, radiation therapy, etc., can solve problems such as reduced control accuracy and stability, poor compatibility, etc.

Active Publication Date: 2022-08-02
JINAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the above schemes require invasive implantation of external materials, such as implanting magnetically controlled nanoparticles, ultrasound sources, and metal electrodes into blood vessels as manipulation markers or excitation sources. The above materials themselves are poorly compatible with organisms and are prone to induce The immune system feedback in the body reduces the accuracy and stability of the control

Method used

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  • A device for regulating red blood cells in the blood vessels of living animals
  • A device for regulating red blood cells in the blood vessels of living animals
  • A device for regulating red blood cells in the blood vessels of living animals

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Embodiment 1

[0073] 1. The device of the present invention is built around a scanning optical tweezers system (Tweez250si, Aresis Company), such as figure 2 shown. The laser wavelength was set to 1064 nm. First, the outgoing laser will interact with the acousto-optic polarizer to achieve dynamic scanning of the laser focus with a scanning frequency of 100 KHz. After being adjusted by the acousto-optic polarizer, the laser beam is broadened by a beam broadening device composed of a double lens, and focused on the sample surface by a 60´ water immersion objective. The experimental process was observed and video recorded in real time through a CCD camera connected to a computer. The requirements of each component in the experimental device are as follows:

[0074] 1) Laser: emit single-mode laser with a wavelength of 1064nm. The power requirement is continuously adjustable from 0 to 4 W;

[0075] 2) Acousto-optic modulator: The outgoing laser is vertically incident on the surface of the...

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Abstract

The invention provides a device for regulating red blood cells in a blood vessel of a living animal and an application thereof, belonging to the field of optoelectronic technology; the device comprises a laser emission component, an acousto-optic modulation component, a beam broadening component, a short-wave pass dichroic component in sequence along a laser path mirror and inverted objective lens; the device also includes image input and output components, a convex lens, a concentrator and a white light emitting component on the imaging optical path; after the laser emitted from the laser emitting component passes through the acousto-optic modulation component and the beam broadening component in sequence, irradiates the Change the transmission direction of the laser light on the short-wave pass dichroic mirror; after changing the transmission direction, the laser light is focused to the sample chamber through the inverted objective lens. The laser emitted by the laser emitting component will interact with the acousto-optic modulation component to realize the dynamic scanning of the laser focus. Fast scanning can realize the quasi-static distribution of the laser focus in multiple positions, and then be applied to the stable capture and precise arrangement of multiple red blood cells. and rotation control.

Description

technical field [0001] The invention relates to the field of optoelectronic technology, in particular to a device for regulating red blood cells and its application. Background technique [0002] It is well known that there is a complex vascular network system in animals, which supplies fresh oxygen and nutrients to tissues and organs through continuous blood flow, and takes away metabolic products such as carbon dioxide to maintain normal physiological balance in the body. In-depth understanding of the physiological mechanism of blood flow, non-contact precise intervention and multi-functional control of blood flow will provide potential ideas and alternatives for further clinical diagnosis and treatment, drug delivery and anti-cancer treatment. [0003] At present, technologies based on magnetic fields, ultrasound, and electric fields have been applied to the dynamic regulation of blood flow. However, the above solutions require the invasive implantation of external mater...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/49A61N5/067
CPCA61N5/06A61N2005/0626A61N2005/0632A61N2005/0664A61N5/067
Inventor 刘晓帅李宝军李宇超高晴张垚
Owner JINAN UNIVERSITY
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