Biodegradable medical dressing and preparation method thereof

Abstract

The invention discloses a biodegradable medical dressing and a preparation method thereof. A side, close to a wound surface, of the biodegradable medical dressing serves as an inner layer; the biodegradable medical dressing sequentially comprises an isolation layer, an antibacterial healing promoting layer, an repair inducing layer and a back lining layer from inside to outside; the sizes of the isolation layer and the back lining layer are larger than the sizes of the antibacterial healing promoting layer and the repair inducing layer; the antibacterial healing promoting layer is prepared from the following raw materials in parts by weight: poly(3-hydroxybutyrate-co-3-hydroxyvalerate), type I collagen, hydroxypropyl cellulose, bioactive glass, a silver nitrate solution, cocoa seed butter,1 to 3 parts of glycerol, acetic acid and a solvent; and the repair inducing layer is prepared from the following raw materials in parts by weight: carbomer, hydroxypropyl tetrahydropyrantriol, glycyl-l-histidyl-l-lysine, superoxide dismutase, resveratrol and a wetting agent. According to the dressing, the antibacterial healing promoting layer and the repair inducing layer have a synergistic effect, and wound healing and scar repair are combined. The antibacterial healing promoting layer is made of a biodegradable high polymer material, has low immunogenicity, and thus can facilitate wound healing.

Description

technical field [0001] The invention relates to a medical dressing, in particular to a biodegradable medical dressing and a preparation method thereof. Background technique [0002] The healing of skin wounds is a complex dynamic process, mainly involving three overlapping stages of inflammation, proliferation and remodeling. In the process of wound healing, medical dressings play an important role. Traditional gauze dressings are mainly made of cotton and hemp raw materials through deep processing. Causes secondary mechanical damage during drug use. In addition, traditional dressings are not antibacterial, and the wound surface is susceptible to bacterial infection, producing unpleasant odors and causing wound complications, which is not conducive to wound healing. With the advancement of modern technology, new types of medical dressings continue to emerge, and new clinical efficacy is also constantly improving. [0003] Biodegradable materials in medicine refer to a cla...

AI Technical Summary

Problems solved by technology

The advantage of this type of material is that the degradation products are easily absorbed without inflammatory response, but they have the weakness of poor mechanical properties, and due to different sources of natural materials, the molecular weight and physical properties of the same material may also have certain differences. destabilizing effect on the release properties of the

(2) Synthetic degradable polymer materials: they are the main research objects of biomaterials for tissue engineering at present, among which polylactide series materials are the main ones; the degradation speed and strength of this kind of materials can be adjusted, and it is easy to shape and construct high-quality materials. Porous three-dimensional scaffolds, the defect of this kind of material is that the concentrated release of its degradation products is easy to produce inflammatory reaction, which will make the contact environment too acidic, and this kind of material has weak affinity to cells and poor adhesion to cells. It is beneficial to the healing of the wound, and the wound after healing is prone to scarring, which affects the appearance

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