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Traditional Chinese medicine composition for inhibiting helicobacter pylori and preparation method thereof

A Helicobacter pylori, anti-Helicobacter pylori technology, applied in the direction of antibacterial drugs, pharmaceutical formulations, food science, etc., can solve the problems of the increase of Hp strains and the lack of effective drugs to inhibit Hp, and achieve strong inhibition and drug resistance. The effect of low rate and few adverse reactions

Active Publication Date: 2020-09-11
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the technical problems such as the increase of antibiotic-resistant Hp strains in the prior art and the lack of drugs for effectively inhibiting Hp, and to provide a Chinese medicine composition for inhibiting Hp and a preparation method thereof

Method used

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  • Traditional Chinese medicine composition for inhibiting helicobacter pylori and preparation method thereof
  • Traditional Chinese medicine composition for inhibiting helicobacter pylori and preparation method thereof
  • Traditional Chinese medicine composition for inhibiting helicobacter pylori and preparation method thereof

Examples

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Effect test

Embodiment 1

[0025] A traditional Chinese medicine composition for inhibiting Helicobacter pylori, comprising 15 parts of green fruit, 6 parts of Huai Mi and 5 parts of licorice in parts by weight.

[0026] The preparation method of the above-mentioned Chinese medicine composition for inhibiting Helicobacter pylori is characterized in that it comprises the following steps:

[0027] S1. Mix green fruit, pagoda japonica and licorice according to the proportion, and add 10-15mL of water per gram of medicinal material;

[0028] S2. Boil the mixture obtained in step S1 in an electric heating mantle at a voltage of 220V and then decoct at a voltage of 100V for 1 to 3 hours to obtain an extract;

[0029] S3. Purify the extract obtained in step s2. The specific purification method is: filter the extract with two layers of medium-speed filter paper while it is hot, remove the filter residue, concentrate the filtrate by rotary evaporation under reduced pressure, refrigerate at -80°C overnight for p...

Embodiment 2

[0031] A traditional Chinese medicine composition for inhibiting Helicobacter pylori, comprising 5 parts of green fruit, 1 part of Sophora japonica and 0.5 part of licorice in parts by weight.

[0032] The preparation method of the above-mentioned Chinese medicine composition for inhibiting Helicobacter pylori is characterized in that it comprises the following steps:.

[0033] S1. Mix green fruit, pagoda japonica and licorice according to the proportion, and add 10-15mL of water per gram of medicinal material;

[0034] S2. Boiling the mixture obtained in step S1 in an electric heating mantle at a voltage of 220V and then decocting at a voltage of 100V for 1 to 3 hours to obtain an extract;

[0035] S3. Purify the extract obtained in step S2. The specific purification method is: filter the extract with two layers of medium-speed filter paper while it is hot, remove the filter residue, concentrate the filtrate by rotary evaporation under reduced pressure, refrigerate at -80°C ...

Embodiment 3

[0037] A traditional Chinese medicine composition for inhibiting Helicobacter pylori, comprising 10 parts of green fruit, 3 parts of Huai Mi and 1 part of licorice in parts by weight.

[0038] The preparation method of the above-mentioned Chinese medicine composition for inhibiting Helicobacter pylori is characterized in that it comprises the following steps:

[0039] S1. Mix green fruit, pagoda japonica and licorice according to the proportion, and add 10-15mL of water per gram of medicinal material;

[0040] S2. Boil the mixture obtained in step S1 in an electric heating mantle at a voltage of 220V and then decoct at a voltage of 100V for 1 to 3 hours to obtain an extract;

[0041] S3. Purify the extract obtained in step S2. The specific purification method is: filter the extract with two layers of medium-speed filter paper while it is hot, remove the filter residue, concentrate the filtrate by rotary evaporation under reduced pressure, refrigerate at -80°C overnight for pr...

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Abstract

The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for inhibiting helicobacter pylori and a preparation method thereof. Thetraditional Chinese medicine composition comprises the following components in parts by weight: 5-15 parts of fructus canarii, 0-6 parts of flos sophorae immaturus and 0-5 parts of radix glycyrrhizae. The traditional Chinese medicine composition for inhibiting the helicobacter pylori disclosed by the invention has the action characteristics of multiple components, multiple ways and multiple targets, and a traditional Chinese medicine therapy method is low in drug resistance occurrence rate, few in adverse reactions and good in patient medication compliance. The composition is reasonable in compatibility, has a strong inhibiting effect on helicobacter pylori antibiotic-sensitive strains and drug-resistant strains, prevents bitter cold from injuring the stomach, and is suitable for helicobacter pylori infected people, and the use of antibiotics can be reduced by applying traditional Chinese medicines, so that the drug resistance rate of the helicobacter pylori is reduced.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for inhibiting Helicobacter pylori and a preparation method thereof. [0002] technical background [0003] Helicobacter pylori (Hp) is a helical, microaerophilic, Gram-negative bacterium that colonizes the stomach of about 50% of the world's population. Studies have shown that the rate of H. pylori infection has continued to increase over the past three decades. The fifth national consensus report on the management of Helicobacter pylori infection pointed out that Hp infection is an infectious disease, regardless of whether there are clinical symptoms, once infected, eradication treatment should be carried out. Hp infection is closely related to a variety of gastrointestinal diseases such as gastritis, peptic ulcer, mucosa-associated lymphoid tissue lymphoma and gastric cancer, and is also related to a variety of extra-gastr...

Claims

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Application Information

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IPC IPC(8): A61K36/489A61P31/04A23L33/105
CPCA23V2002/00A61K36/32A61K36/484A61K36/489A61K2236/331A23L33/105A61P31/04A61K2300/00A23V2200/32
Inventor 姚美村彭昶申雪袁月梅严家慧张唯佳陈鹏婷
Owner SHANDONG NEWTIME PHARMA
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