Traditional Chinese medicine composition for treating myelodysplastic syndromes (MDS), and preparation method thereof
A technology for myelodysplasia and composition, which is applied in the directions of drug combination, pharmaceutical formula, and inactive ingredient medical preparations, etc., can solve the problems of complex composition, limited therapeutic effect, cumbersome preparation method, etc., and achieves high total effective rate, Significant curative effect and enhanced efficacy
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[0045] In a second aspect, the present invention provides a method for preparing the above-mentioned traditional Chinese medicine composition, comprising the following steps:
[0046] Step 1. Preparation of inclusion compound: preparing orange peel water decoction and inclusion compound of dried orange peel volatile oil.
[0047] Extracting tangerine peel into volatile oil and water decoction can retain the active ingredients in tangerine peel to the greatest extent, and inclusion of volatile oil can solidify liquid medicine, greatly improving its stability.
[0048] Sub-step 1: steam distillation and extraction of tangerine peel to obtain tangerine peel volatile oil and tangerine peel water decoction.
[0049] In the above-mentioned distillation extraction process, the mass ratio of orange peel and water is 1: (6-10), preferably 1:8; the extraction time is 7-13 hours, preferably 8 hours, to obtain orange peel volatile oil and orange peel distillate; The tangerine peel distil...
Embodiment 1
[0070] The Chinese medicine composition of the present embodiment comprises following bulk drug:
[0071] 15.1g realgar powder, 30.2g Qingdai powder, 906g white peony root, 453g bran-fried Atractylodes macrocephala,
[0072] Fangfeng 453g, tangerine peel 453g;
[0073] Also includes: Beta-Cyclodextrin 60.4g.
[0074] The preparation method of above-mentioned Chinese medicine composition comprises the steps:
[0075] (1) Distillation and extraction: the tangerine peel is subjected to steam distillation and extraction treatment to obtain tangerine peel volatile oil and tangerine peel water decoction.
[0076] Among them, the mass ratio of tangerine peel and water is 1:8, and the extraction time is 8 hours to obtain tangerine peel volatile oil and tangerine peel distillate; then filter the tangerine peel distillate to obtain the filtrate as tangerine peel water decoction, and collect it in another device for later use.
[0077] (2) Inclusion: the above-mentioned tangerine peel...
Embodiment 2
[0090] This embodiment is the pilot test and molding process of the traditional Chinese medicine composition, taking 1000 prescriptions of medicinal materials, and preparing the traditional Chinese medicine composition capsule.
[0091] The present embodiment is to get the medical material of 1000 prescription quantities.
[0092] Pilot test:
[0093] Take 6kg of Radix Paeoniae Alba, 3kg of Bran-fried Atractylodes Rhizoma Atractylodes Rhizome, and 3kg of Fangfeng. Add 120L of water for extraction, extract twice, each time for 1.5 hours, filter the medicinal solution, and combine the filtrates. Take 3 kg of tangerine peel and extract separately, add 18 L of water, and extract for 8 hours to obtain 50 mL of volatile oil of tangerine peel and medicinal solution, which is filtered for later use. The above filtrates were combined. Concentrate the filtrate at 85°C to the first clear paste with a relative density of 1.05-1.10 (60°C), add ethanol to make the alcohol content 50%, le...
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