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Method for separating and extracting cannabidiol

A cannabidiol and screening technology, applied in the field of biomedicine, can solve the problems of poor purification effect and the like

Pending Publication Date: 2020-09-25
ZHEJIANG SHOUXIANGU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a method for separating and extracting cannabidiol, which solves the problem of poor purification effect

Method used

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  • Method for separating and extracting cannabidiol
  • Method for separating and extracting cannabidiol
  • Method for separating and extracting cannabidiol

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 A method for separating and extracting cannabidiol

[0035] This embodiment is a method for separating and extracting cannabidiol, comprising the following steps in sequence:

[0036] 1) Pulverization: Take hemp leaves as raw materials, pulverize them through a pulverizer, and sieve through a 40-mesh sieve to obtain a powder with a particle size of ≤40 mesh, which is material A;

[0037] Crush the hemp leaves to less than 40 meshes, which is helpful for the dissolution of cannabidiol (CBD), and can better increase the extraction rate of CBD.

[0038] 2) Three extractions: Take 1kg of material A and soak it in 10L of ethanol at 25°C for 12 hours, then filter to obtain filtrate B and 0.987 kg of residue C;

[0039] Residue C was then soaked in 10 L of ethanol at 25°C for 12 hours, filtered to obtain filtrate D and 0.969 kg of residue E;

[0040] Finally, the residue E was soaked in 10 L of ethanol at 25°C for 12 hours, then filtered to obtain the filtrate F an...

Embodiment 2-6

[0068] Example 2-6 The method of separating and extracting cannabidiol

[0069] Examples 2-6 are respectively a method for separating and extracting cannabidiol, and their steps are basically the same as in Example 1, the only difference being that the process parameters are different, see Table 1 for details:

[0070] List of various process parameters in table 1 embodiment 2-7

[0071]

[0072] The content of other parts of embodiment 2-7 is the same as embodiment 1.

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Abstract

The invention belongs to the technical field of biological medicines and discloses a method for separating and extracting cannabidiol. The preparation method comprises the following steps: crushing and screening hemp leaves serving as a raw material; extracting hemp leaves for three times by ethanol at 20 to 35 DEG C; carrying out concentration, eluting the obtained extract by silica gel column chromatography, wherein the eluent is a petroleum ether / dichloromethane mixed solution with the volume ratio of 50: 1, a petroleum ether / ethyl acetate mixed solution with the volume ratio of 100: (1-2)or a petroleum ether / dichloromethane / ethyl acetate mixed solution with the volume ratio of (200-100): 1: 1; collecting and concentrating the eluent until the purity is greater than or equal to 90%, and concentrating and crystallizing the eluent to obtain cannabidiol. The purity of the crude cannabidiol product obtained through separation and extraction exceeds 90%, the purity of the refined cannabidiol product is larger than or equal to 99%, the content of tetrahydrocannabinol is smaller than or equal to 0.2%, and the problem that the purification effect is poor is solved. The method is used for separating and extracting cannabidiol.

Description

technical field [0001] The invention belongs to the technical field of biomedicine and relates to a method for producing cannabidiol, in particular to a method for separating and extracting cannabidiol. Background technique [0002] Cannabidiol, referred to as CBD, is the main chemical component of the medicinal plant cannabis, which has pharmacological effects such as anti-epilepsy, anti-anxiety, pain relief and anti-inflammation, blocking breast cancer metastasis and treating neonatal hypoxic-ischemic encephalopathy . Cannabidiol can not only be used for the treatment of many difficult diseases, but also can effectively eliminate the hallucinogenic effect of tetrahydrocannabinol (THC) on the human body, and is called "anti-drug compound". The application of cannabidiol in the medical field is mainly based on its protective effect on the nervous system. And it has stable genetics and good pharmacokinetic properties. Scientists have synthesized a series of cannabidiol anal...

Claims

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Application Information

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IPC IPC(8): C07C37/70C07C37/72C07C37/82C07C37/84C07C39/23
CPCC07C37/004C07C37/685C07C37/72C07C37/82C07C37/84C07C2601/16C07C39/23
Inventor 李明焱王彩霞李振皓李振宇王瑛徐靖
Owner ZHEJIANG SHOUXIANGU PHARMA CO LTD
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