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Degradable self-healing chitosan composite aldehyde guar gum hydrogel as well as preparation method and application thereof

A guar gum and aldehyde-based technology, applied in the field of degradable self-healing chitosan complex aldehyde-based guar gum hydrogel and its preparation, can solve the problem of excessive modification and undiscussed hydrogel self-healing And degradability and other issues, to achieve the effect of broad application prospects, good solubility, good biocompatibility

Inactive Publication Date: 2020-10-02
WUHAN INSTITUTE OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The raw materials used in this preparation method are too modified, and the method does not discuss the self-healing and degradability of the hydrogel

Method used

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  • Degradable self-healing chitosan composite aldehyde guar gum hydrogel as well as preparation method and application thereof
  • Degradable self-healing chitosan composite aldehyde guar gum hydrogel as well as preparation method and application thereof
  • Degradable self-healing chitosan composite aldehyde guar gum hydrogel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Step (1): Dissolving CHI (5 g) in 100 mL of hydrochloric acid solution with pH = 3, dialysis in a dialysis bag for 7 days, and then freeze-drying to obtain protonated CHI soluble in deionized water;

[0054] Step (2): Dissolve 2g of GG in 100mL of deionized water, and stir magnetically at room temperature until completely dissolved;

[0055] Step (3): Dissolve 0.44g of sodium periodate in 10mL of deionized water, add dropwise to the GG solution and stir evenly;

[0056] Step (4): Stir the mixed solution at room temperature in the dark for 12 hours, and the oxidation reaction occurs to generate AGG;

[0057] Step (5): Add 1 mL of ethylene glycol to the solution in step (4) and stir for 1 h to terminate the reaction. Pour AGG into a dialysis bag for dialysis for 7 days, spin-evaporate and freeze-dry for 3 days for later use;

[0058]Step (6): The protonated CS solution with a mass fraction of 7% and the AGG with a mass fraction of 15% were uniformly mixed at a volume ra...

Embodiment 2

[0060] Step (1): Dissolving CHI (5 g) in 100 mL of hydrochloric acid solution with pH = 4, dialysis in a dialysis bag for 10 days, and then freeze-drying to obtain protonated CHI soluble in deionized water;

[0061] Step (2): Dissolve 2g of GG in 100mL of deionized water, and stir magnetically at room temperature until completely dissolved;

[0062] Step (3): Dissolve 1.2g of sodium periodate in 10mL of deionized water, add dropwise to the GG solution and stir evenly;

[0063] Step (4): Stir the mixed solution at room temperature in the dark for 10 hours, and the oxidation reaction occurs to generate AGG;

[0064] Step (5): Add 1.5 mL of ethylene glycol to the solution in step (4) and stir for 1.5 h to terminate the reaction. Pour AGG into the dialysis bag for dialysis for 15 days, then spin evaporate, and freeze-dry the solution obtained by spin steam for 5 days for later use;

[0065] Step (6): The protonated CHI solution with a mass fraction of 5% and the AGG with a mass ...

Embodiment 3

[0067] Step (1): Dissolving CHI (5 g) in 100 mL of hydrochloric acid solution with pH = 5, dialyzed in a dialysis bag for 14 days, and then evaporating, and lyophilizing the evaporating solution to obtain protonated CHI soluble in deionized water;

[0068] Step (2): Dissolve 2g of GG in 100mL of deionized water, and stir magnetically at room temperature until completely dissolved;

[0069] Step (3): Dissolve 2.3g of sodium periodate in 10mL of deionized water, add dropwise to the GG solution and stir evenly;

[0070] Step (4): Stir the mixed solution at room temperature in the dark for 6 hours, and the oxidation reaction occurs to generate AGG;

[0071] Step (5): Add 2 mL of ethylene glycol to the solution in step (4) and stir for 6 h to terminate the reaction. Pour AGG into the dialysis bag for dialysis for 14 days, then spin evaporate, and freeze-dry the spin evaporate liquid for 3 days for later use;

[0072] Step (6): The protonated CS solution with a mass fraction of 6%...

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Abstract

The invention belongs to the technical field of hydrogel materials, and particularly relates to degradable self-healing chitosan composite aldehyde guar gum hydrogel as well as a preparation method and application thereof. The method comprises the following steps: 1) obtaining a chitosan (CHI) solution; 2) preparing a solution of aldehyde guar gum (AGG); and 3) carrying out a reaction on the solution of aldehyde guar gum with the solution of chitosan to prepare the degradable self-healing chitosan composite aldehyde guar gum hydrogel. According to the preparation method, an aldehyde group on an AGG chain and an amino group on a CHI chain are subjected to a Schiff base reaction to form an imine bond, and the CHI / AGG hydrogel is obtained by taking the imine bond as a cross-linking point. Dueto a dynamic crosslinking mechanism, the hydrogel can realize self-healing within 5 minutes and can be degraded near a neutral environment.

Description

technical field [0001] The invention belongs to the technical field of hydrogel materials, and in particular relates to a degradable self-healing chitosan composite aldylated guar gum hydrogel and a preparation method and application thereof. Background technique [0002] A hydrogel is a high molecular polymer with a three-dimensional network structure that can absorb large amounts of water or biological fluids. It can be chemically stable, or it can degrade and eventually disintegrate or dissolve. Hydrogels have a wide range of applications and prospects in biomedical fields such as biosensors, tissue engineering scaffolds, drug carriers, artificial implants, and cell or ion growth templates. [0003] Self-healing hydrogels refer to hydrogels that enable materials to heal damage and restore their normal properties in essence. Self-healing typically occurs in prepared materials without the intervention of external stimuli that promote self-healing to occur. It is an import...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/08C08L5/00C08B37/00
CPCC08J3/075C08B37/0096C08J2305/00C08J2405/08
Inventor 吴江渝王映桂刘璨曾小平王大威郑华明
Owner WUHAN INSTITUTE OF TECHNOLOGY
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