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Process for removing tetrahydrocannabinol in cannabidiol

A technology of tetrahydrocannabinol and cannabidiol, which is applied in the chemical field, can solve problems such as difficult cost comparison, and achieve the effects of low cost, easy operation, and mild reaction conditions

Active Publication Date: 2020-10-13
云南古润生物科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, industrial hemp processing companies mainly extract cannabidiol products. Due to the problem of the extraction process, the extracted cannabidiol products contain tetrahydrocannabinol. However, tetrahydrocannabinol is an addictive drug and requires The content of THC is less than 0.3%. At present, the method of chromatography is basically used to remove THC from cannabidiol products. The tetrahydrocannabinol in cannabidiol is relatively difficult and the cost ratio is high. In view of the above problems, a process for removing THC in cannabidiol is needed in the industry to solve the problems faced by the industry

Method used

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  • Process for removing tetrahydrocannabinol in cannabidiol

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Experimental program
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Embodiment 1

[0031] A process for removing tetrahydrocannabinol in cannabidiol, the process steps are as follows:

[0032] A. Prepare 100g cannabidiol raw material 1, the content of cannabidiol in the cannabidiol raw material 1 is greater than or equal to 50g, add methyl chloride solution 2 to the cannabidiol raw material 1 to form the first mixed liquid 4, methyl chloride solution 2 The content of cannabidiol is 500ml, and the first mixed liquid 4 is stirred until the cannabidiol raw material 1 is completely dissolved, and then the first mixed liquid 4 is cooled to -5°C;

[0033] B. Use a separating funnel to add bromine solution 5 dropwise to the first mixed liquid 4 at an even speed to form the second mixed liquid 6. The dropping process is completely protected from light and kept stirring. The molar concentration of the bromine solution 5 is 0.3mol / L , the ratio of the bromine solution 5 to the cannabidiol raw material 1 is 1.0mol-1.05mol: 1mol. After the bromine solution 5 is added dr...

Embodiment 2

[0041] A. Prepare 150g cannabidiol raw material 1, the cannabidiol content in the cannabidiol raw material 1 is greater than or equal to 50g, add chloroform solution 3 to the cannabidiol raw material 1 to form the first mixed liquid 4, the content of chloroform solution 3 750ml, stir the first mixed liquid 4 until the cannabidiol raw material 1 is completely dissolved, and then cool down the first mixed liquid 4 to -8°C;

[0042] B. Use a separating funnel to add bromine solution 5 dropwise to the first mixed liquid 4 at an even speed to form the second mixed liquid 6. The dropping process is completely protected from light and kept stirring. The molar concentration of the bromine solution 5 is 0.3mol / L , the ratio of the bromine solution 5 to the cannabidiol raw material 1 is 1.0mol-1.05mol: 1mol. After the bromine solution 5 is added dropwise, monitor it with a TLC board every half an hour to observe the bromination of cannabidiol and the reaction time for 5 hours;

[0043]...

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Abstract

The invention relates to a process for removing tetrahydrocannabinol in cannabidiol, and belongs to the technical field of chemistry. The process includes following steps: dropwise adding a bromine solution into the first mixed liquid to form a second mixed liquid, adding absolute ethyl alcohol into the concentrate to form a fourth mixed liquid, adding a second chloromethane solution or a second chloroform solution into the brominated cannabidiol crystals to form a fifth mixed liquid, and adding zinc powder into the sixth mixed liquid to form a seventh mixed liquid. The beneficial effects of the invention are that by means of the bromination reaction on olefinic bonds in a cannabidiol structure and bromine liquid under specific conditions; therefore, the polarity is changed, and the solubility difference of brominated cannabidiol and tetrahydrocannabinol in ethanol is increased; after crystallization, the brominated cannabidiol crystal can be completely separated from the tetrahydrocannabinol; and a reduction reaction is carried out on the brominated cannabidiol to obtain the cannabidiol with the tetrahydrocannabinol being completely removed. According to the invention, the methodhas the advantages that the reaction conditions are mild, the operation is easy, the cost is low, and the content of tetrahydrocannabinol in the cannabinol product can be favorably controlled in industrial production.

Description

Technical field: [0001] The invention relates to a process for removing tetrahydrocannabinol from cannabidiol, which belongs to the field of chemical technology. Background technique: [0002] Cannabidiol, referred to as CBD, English: cannabidiol, is a pure natural ingredient extracted from the hemp plant. The molecular formula of cannabidiol is C21H30O2, and its properties are white to light yellow resin or crystal, with a melting point of 66°C~67°C, almost insoluble in water, and soluble in organic solvents such as ethanol, methanol, ether, benzene, and chloroform. Cannabidiol can block the adverse effects of certain polyphenols on the human nervous system, and has a series of physiologically active functions such as blocking breast cancer metastasis, treating epilepsy, anti-rheumatoid arthritis, and anti-insomnia. Has a good effect. [0003] Tetrahydrocannabinol referred to as THC, English: Tetrahydrocannabinol, also known as Δ9-tetrahydrocannabinol (Δ9-THC), Δ1-THC (ac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/00C07C39/21C07C37/62C07C37/72C07C37/84C07C39/42
CPCC07C37/002C07C37/62C07C37/72C07C37/84C07C2601/16C07C39/42C07C39/21
Inventor 曹建锋李卫星陈梦达
Owner 云南古润生物科技有限责任公司