Rare earth photo-thermal nano particle and preparation method thereof

A technology of nano-particles and rare earth ions, applied in nano-technology, nano-optics, nano-technology, etc., can solve problems such as limited scope of application, poor light-to-heat conversion characteristics, complex synthesis methods, etc., and achieve simple process and reaction conditions and large application Foreground, the effect of increasing the intensity of up-converted luminous

Active Publication Date: 2020-10-16
HUZHOU TEACHERS COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In response to the above problems, the present invention researches and designs a kind of rare earth photothermal nanoparticles and its preparation method to solve the shortcomings of traditional photothermal nanoparticles, such as complex synthesis methods, poor photothermal conversion characteristics, and limited scope of application.

Method used

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  • Rare earth photo-thermal nano particle and preparation method thereof
  • Rare earth photo-thermal nano particle and preparation method thereof
  • Rare earth photo-thermal nano particle and preparation method thereof

Examples

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Embodiment 1

[0027] A Rare Earth Photothermal Nanoparticle NaYF 4 :20%Yb 3+ / 1%Er 3+ @NaYF 4 @NaYF 4 :20%Yb 3+ / 5%Sm 3+ , under a single 980nm excitation, its inner layer emits strong green up-conversion luminescence, which can be used for fluorescent marking and luminous temperature sensing; the outer layer absorbs infrared radiation and converts it into heat; the middle layer is a transparent isolation layer in the visible band, used for blocking Break the energy transfer channel between the dopant ions in the light-emitting layer and the heat-generating layer.

[0028] The preparation method of the above-mentioned rare earth photothermal nanoparticles comprises the following steps:

[0029] S1, preparation of the inner core solution: according to the molar ratio Yb 3+ :Er 3+ :Y 3+ =20:1:79 Take a total of 2mL of acetate aqueous solution and add it to a three-necked flask. Under the condition of magnetic stirring, add 3mL of oleic acid and 8mL of octadecene to the above solution...

Embodiment 2

[0033] A Rare Earth Photothermal Nanoparticle NaYF 4 :20%Yb 3+ / 1%Er 3+ @NaYF 4 @NaYF 4 :20%Nd 3+ / 5%Sm 3+ , under the co-excitation of dual wavelengths of 808nm and 980nm, its inner layer absorbs 980nm photons and emits strong green upconversion luminescence, which can be used for fluorescent marking and luminescent temperature sensing; the outer layer absorbs 808nm infrared radiation and converts it into heat; the middle layer is visible The band-transparent isolation layer is used to block the energy transfer channel between the light-emitting layer and the dopant ions in the heat-generating layer.

[0034] The preparation method of the above-mentioned rare earth photothermal nanoparticles comprises the following steps:

[0035] S1, preparation of the inner core solution: according to the molar ratio Yb 3+ :Er 3+ :Y 3+ =20:1:79 Take a total of 2mL of acetate aqueous solution and add it to a three-necked flask. Under the condition of magnetic stirring, add 3mL of ol...

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Abstract

The invention discloses a rare earth photo-thermal nano particle and a preparation method thereof. The rare earth photo-thermal nano particle comprises an inner layer, a middle layer and an outer layer; the inner layer is a light-emitting layer with up-conversion luminescence and optical temperature sensing functions, the outer layer is a heating layer with a photo-induced heating function, and the middle layer is an isolation layer for blocking energy transfer between doping ions of the inner layer and doping ions of the outer layer. The invention further discloses a preparation method of therare earth photo-thermal nano particle. The process and reaction conditions for preparing the rare earth photo-thermal nano particle are simple, and the prepared rare earth photo-thermal nano particle has significantly improved up-conversion luminescence intensity, temperature detection signal-to-noise ratio and photo-thermal conversion performance, so that the rare earth photo-thermal nano particle has great application prospects in tumor targeted photo-thermal therapy.

Description

technical field [0001] The invention relates to the field of tumor photothermal therapy, in particular to a rare earth photothermal nano particle and a preparation method thereof. Background technique [0002] Compared with traditional tumor treatment methods that often bring huge physical and mental torture to patients, thermal therapy has almost zero side effects, and is called "green therapy" by the international medical community. At present, a variety of hyperthermia techniques including radiofrequency, microwave, laser, focused ultrasound, whole-body hyperthermia and isolated perfusion have been developed, but these hyperthermia techniques are poorly targeted, and while heating tumor tissue, often lead to damage to surrounding health. The thermal damage to the tissue limits its clinical application. In recent years, nanoparticle-mediated photothermal therapy has attracted much attention. In this method, nanoparticles injected into tumor tissue first absorb external n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/85B82Y20/00B82Y30/00B82Y40/00C09K5/14A61K41/00A61P35/00B82Y5/00
CPCC09K11/7773B82Y20/00B82Y30/00B82Y40/00C09K5/14A61K41/0052A61P35/00B82Y5/00
Inventor 庞涛
Owner HUZHOU TEACHERS COLLEGE
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