Graphene nanocomposite for treating burn wound multi-drug-resistant bacterial infection

Abstract

The invention relates to the technical field of medical treatment, in particular to a graphene nanocomposite for treating burn wound multi-drug-resistant bacterial infection, which comprises the following steps: A, designing and preparing; B, characterization performance research: (1) hydrated particle size detection, (2) photo-thermal performance detection, (3) material stability analysis, (4) material surface size and morphology size analysis, (5) Fourier transform infrared spectrum, ultraviolet-visible light absorption spectrum and Raman spectrum analysis, and (6) material component analysis. Carboxylated graphene is used as a carrier, polydopamine is loaded on the surface, ethylene glycol chitosan is cross-linked into the system to prepare a modified graphene nano material, and finally, the modified graphene nano material is loaded on GCS-PDA-coated CG through non-covalent bond binding, the efficient photo-thermal induced targeted graphene nano antibacterial material (AIBI-GCS-PDA(@) CG) is formed, alkyl radicals can be released to kill multi-drug-resistant bacteria, and a new treatment strategy is expected to be provided for infection of the multi-drug-resistant bacteria on burn wounds.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a graphene nanocomposite material for the treatment of multidrug-resistant bacterial infections on burn wounds. Background technique [0002] With the development of modern medical technology, the success rate of anti-shock resuscitation in the early stage of burn injury has been significantly improved. The incidence of infection has risen dramatically, posing a serious challenge to the health of burn patients. Wound multidrug-resistant bacterial infection will not only aggravate wound deterioration, delay healing, and even lead to sepsis and eventually death, and has become one of the main causes of death in burn patients [1-3] . Due to the irrational use and slow development of antibiotics, the world is facing an incurable bacterial infection, which can be very serious and catastrophic. [4-6] . Therefore, the control of multidrug-resistant bacterial infection in wounds is ...

AI Technical Summary

Problems solved by technology

[0002] With the development of modern medical technology, the success rate of anti-shock resuscitation in the early stage of burn inju...