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Application of cashew nut shell oil active substance as melanin generation and transfer inhibitor

A technology of cashew nut shell oil and active substances, which can be used in skin care preparations, medical preparations containing active ingredients, cosmetic preparations, etc., and can solve problems such as poor stability

Inactive Publication Date: 2020-10-30
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The currently widely used melanin deposition inhibitors are mainly kojic acid or arbutin, which have good inhibitory activity but poor stability

Method used

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  • Application of cashew nut shell oil active substance as melanin generation and transfer inhibitor
  • Application of cashew nut shell oil active substance as melanin generation and transfer inhibitor
  • Application of cashew nut shell oil active substance as melanin generation and transfer inhibitor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0026] The effect research of the melanin deposition inhibitor of the present invention mainly comprises the following steps:

[0027] The zebrafish were treated with the crude extract of cashew nut shell oil (CNCE), and the melanin in the zebrafish was directly observed and measured through a stereoscope and lysed fish body.

[0028] Zebrafish egg culture and drug treatment with CNCE:

[0029] Select a normal, healthy female zebrafish that is about to spawn and place it in the incubation system, and take another healthy sexually mature male zebrafish to mate with it. Before mating, use a partition to isolate it overnight, and take it out for isolation at 9:00 the next morning. After about 30 minutes, start to collect fish eggs. The fertilized zebrafish eggs were placed in a 28 ° incubator for 24 h, 12 h light culture, 12 h dark cult...

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Abstract

The invention discloses an application of cashew nut shell oil active substances as melanin generation and transfer inhibitors, and relates to cashew nut shell oil active substances. The cashew nut shell oil active substances comprise cashew nut shell oil crude extract and cashew nut shell oil refined extract. The cashew nut shell oil crude extract can be obtained by stirring cashew nut shell oilactive substances and an organic solvent, and the mass percent of the cashew nut shell oil active substances to the organic solvent can be (90%-95%): (5%-10%). Experiments show that the cashew nut shell oil crude extract can significantly inhibit the generation of melanin in zebra fish bodies, and the Cardanol diene component in the cashew nut shell oil refined extract can inhibit the generation and transfer of melanin. The cashew nut shell oil active substance has a good inhibition effect on melanin generation and transport, has good stability, and can be used as a melanin generation and transport inhibitor.

Description

technical field [0001] The invention relates to an active material of cashew nut shell oil, in particular to an application of the active material of cashew nut shell oil as an inhibitor of melanin production and transfer. Background technique [0002] Cashew nut shell liquid is a by-product of cashew nut planting and processing, with low price and abundant sources. Natural cashew nut shell oil contains active substances such as about 90% anacardic acid and 10% cardol. Studies have found that cashew nut shell liquid active substances contain many natural unsaturated long-chain phenols, which is one of the important sources of natural phenols. [0003] Melanosome is a subcellular lysosome-like organelle, which is the place where melanin is synthesized and stored before being distributed to the surrounding keratinocytes, and exists in melanocytes. Melanosomes are able to synthesize melanin from tyrosine or phenylalanine through many specific enzymes and mature structural pro...

Claims

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Application Information

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IPC IPC(8): A61K8/92A61Q19/02
CPCA61K8/922A61K2800/782A61Q19/02
Inventor 陈婷苏伟超陈清西王勤石艳
Owner XIAMEN UNIV