Glycyrrhizic acid-based slow-release porous foam material capable of embedding hydrophilic functional factors and preparation method and application thereof

A technology of porous foam materials and functional factors, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve the problems of poor stability, easy scattering, and difficulty in molding.

Active Publication Date: 2020-10-30
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Utilize natural small-molecule surfactants, such as glycyrrhizic acid, the prepared foam has good foaming property (foaming property as high as 300-400%), high porosity (70-98%), and high embedding rate, but the foam produced by independent licorice The foam hydrogel prepared by acid has problems such as poor stability, fragility after freeze-drying, easy to scatter and difficult to form.

Method used

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  • Glycyrrhizic acid-based slow-release porous foam material capable of embedding hydrophilic functional factors and preparation method and application thereof
  • Glycyrrhizic acid-based slow-release porous foam material capable of embedding hydrophilic functional factors and preparation method and application thereof
  • Glycyrrhizic acid-based slow-release porous foam material capable of embedding hydrophilic functional factors and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] In terms of mass fraction, 4 parts of glycyrrhizic acid were uniformly dispersed in 4 parts of deionized water, heated and stirred at 80° C. to obtain a transparent glycyrrhizic acid solution with a concentration of 4 wt%.

[0044] In terms of mass fraction, 4 parts of hydroxyethyl cellulose with different masses were uniformly dispersed in deionized water, heated and stirred at 80°C to obtain transparent hydroxyethyl cellulose with concentrations of 1wt%, 4wt%, and 8wt%, respectively. solution.

[0045] Add 3 parts of hydroxyethyl cellulose transparent solutions of different concentrations to 3 parts of glycyrrhizic acid solutions with the same concentration respectively, and control the final concentration of hydroxyethyl cellulose to be 0.5wt%, 2wt%, 4wt% respectively; at 80 °C in a water bath with stirring.

[0046] The remaining 1 part of glycyrrhizic acid solution and the remaining hydroxyethyl cellulose solution were used as a blank control, heated and stirred i...

Embodiment 2

[0053] In terms of mass fraction, 3 parts of glycyrrhizic acid were uniformly dispersed in deionized water, heated and stirred at 80° C. to obtain a transparent glycyrrhizic acid solution with a concentration of 4 wt%. Three parts of hydroxyethyl cellulose with different masses were uniformly dispersed in deionized water respectively, heated and stirred at 80°C to obtain transparent solutions with different concentrations. Add 3 parts of hydroxyethyl cellulose solutions of different concentrations to 3 parts of glycyrrhizic acid solutions with the same concentration, control the final concentration of hydroxyethyl cellulose to 0.5wt%, 2wt%, 4wt%, heat in a water bath at 80°C and Stir. Homogenize the mixed solution for 2min at a speed of 20000rpm. The foam gel was obtained by placing it in an ice-water bath, and the foam gel was placed in liquid nitrogen for 5 minutes and then freeze-dried to obtain a porous foam material.

[0054] In embodiment 2, image 3 It is the appeara...

Embodiment 3

[0057] In terms of mass fraction, 3 parts of glycyrrhizic acid were uniformly dispersed in deionized water, heated and stirred at 80° C. to obtain a transparent glycyrrhizic acid solution with a concentration of 4 wt%.

[0058] A certain amount of riboflavin sodium phosphate was added to 3 parts of glycyrrhizic acid solution, heated and stirred at 80° C. to obtain a yellow mixed solution containing 20% ​​riboflavin sodium phosphate.

[0059] In terms of mass fraction, 3 parts of hydroxyethyl cellulose with different masses were uniformly dispersed in deionized water, heated and stirred at 80°C to obtain transparent solutions with concentrations of 1 wt%, 4 wt%, and 8 wt%.

[0060] Add 3 parts of hydroxyethyl cellulose solutions of different concentrations to 3 parts of glycyrrhizic acid solutions loaded with riboflavin sodium phosphate respectively, and control the final concentration of hydroxyethyl cellulose to 0.5wt%, 2wt%, 4wt%, Heat and stir in a water bath at 80°C. The ...

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Abstract

The invention discloses a glycyrrhizic acid-based slow-release porous foam material capable of embedding hydrophilic functional factors and a preparation method and application thereof. The method comprises the following steps: respectively and uniformly dispersing glycyrrhizic acid and hydroxyethyl cellulose in water, and heating and stirring to obtain a transparent glycyrrhizic acid solution anda hydroxyethyl cellulose solution; then adding the hydroxyethyl cellulose solution into the glycyrrhizic acid solution, carrying out homogeneous gasification treatment on the mixed solution, and standing in an ice-water bath to obtain foam gel; and carrying out freeze drying treatment on the foam gel to obtain the porous foam material. The obtained product has good mechanical properties, active substance loading capacity and highly controllable release characteristics. The process conditions are simple and rapid, rapid and continuous production can be carried out, foam type products applied to medicine and tissue engineering can be prepared by controlling the process conditions, and the material has industrial and large-scale application value.

Description

technical field [0001] The invention relates to a glycyrrhizic acid-based sustained-release porous foam material embedded with hydrophilic functional factors, in particular to a porous foam induced by natural small molecules and a preparation method thereof; it belongs to the medical fields of drug release and tissue engineering. Background technique [0002] Porous foam material is a new type of functional material composed of a solid skeleton and a large number of pores. The existence of pores reduces the quality of the material. The pore structure makes the foam material have the characteristics of high surface area, low density and good permeability. At present, raw materials used in active transport, such as cellulose and polymers, are endowed with amphiphilicity and environmental stimulus responsiveness due to the chemical structure of the main chain and polymer branch chains, and the polymers can undergo rich self-assembly behaviors. , has important applications in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/54A61L27/50A61L27/20A61K47/38A61K47/28A61K31/525A61K31/675A61P3/02
CPCA61K31/525A61K31/675A61K47/28A61K47/38A61L27/20A61L27/50A61L27/54A61L27/56A61L2300/428A61L2300/602A61P3/02C08L1/284
Inventor 万芝力苏恩谊李青杨晓泉
Owner SOUTH CHINA UNIV OF TECH
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