Chain transfer agent for preparing antibacterial polymer and preparation method thereof

A technology of chain transfer agent and polymer, which is applied in the fields of chemicals for biological control, botanical equipment and methods, animal repellent, etc. question

Inactive Publication Date: 2020-10-30
吴张峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Conventional polymer materials have almost no antibacterial properties, such as polyethylene, polypropylene, polystyrene, polyvinyl chloride, polymethyl methacrylate, etc. In order to make the obtained polymer materials antibacterial, some antibacterial agents are usually added. The antibacterial agent makes the polymer material have antibacterial properties. On the one hand, the added antibacterial agent may have poor compatibility with the polymer material, and the dispersibility is not good. On the other hand, there may be a problem that the antibacterial agent is easy to lose. RAFT chain transfer agent with antibacterial effect, when the RAFT chain transfer agent is used to initiate monomer copolymerization, the copolymerized material has antibacterial properties, and there is no need to add antibacterial agents to the polymer material; in addition, the prepared chain transfer agent can be used as a lubricating oil additive , has good anti-wear and anti-friction effect

Method used

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  • Chain transfer agent for preparing antibacterial polymer and preparation method thereof
  • Chain transfer agent for preparing antibacterial polymer and preparation method thereof
  • Chain transfer agent for preparing antibacterial polymer and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of 2-(Ethylmercaptothioformylthio)-2-methylpropionyl chloride.

[0038] Add 2-(ethylmercaptothioformylthio)-2-methylpropionic acid (5mmol) and 11.2mL carbon tetrachloride into a 25mL branch bottle, mix thoroughly, and then add 1.2mL acyl chloride reagent chlorine Add sulfoxide, stir continuously until clarification; heat the mixed solution to 77°C for 2 hours, after the reaction, evaporate the solvent in a vacuum rotary, petroleum ether: ethyl acetate (v / v) 10:1 as the mobile phase and pass through the column for purification , to obtain a yellow oily liquid, which was dried under vacuum at room temperature to obtain 2-(ethylmercaptothioformylthio)-2-methylpropionyl chloride with a yield of 91.4%.

Embodiment 2

[0040] Preparation of benzyltrithiocarbonate propionyl chloride.

[0041] The same reaction conditions as in Example 1, the chain transfer agent uses benzyl trithiocarbonate propionic acid to replace 2-(ethylmercaptothioformylthio)-2-methyl propionic acid to obtain benzyl trisulfide Substituted carbonyl propionyl chloride, the yield was 87.3%.

Embodiment 3

[0043] N 2 Under protection, 2'-bromo-2,6-difluoro-4-hydroxyacetophenone (5mmol), freshly distilled pyridine (10mmol) and 8mL tetrahydrofuran were added to a 50mL branched-necked flask, and 2'-bromo-2, After 6-difluoro-4-hydroxyacetophenone is completely dissolved; the 2-(ethylmercaptothioformylthio)-2-methylpropionyl chloride (5mmol) prepared in the above steps is dissolved in tetrahydrofuran and heated at 0°C Added dropwise to 2'-bromo-2,6-difluoro-4-hydroxyacetophenone solution, stirred at room temperature for 1 hour, then added 15 mL of chloroform, raised the temperature to 65°C and reacted for 10 hours, and washed with saturated sodium bicarbonate, Deionized water and dilute hydrochloric acid washed the mixed solution, and the obtained crude product was evaporated to dryness under reduced pressure, and petroleum ether: ethyl acetate (v / v) was 12:1 as the mobile phase for column purification to obtain chain transfer agent esterification product A1 , and the yield was 82.6...

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Abstract

The invention discloses a chain transfer agent for preparing an antibacterial polymer and a preparation method of the chain transfer agent. The chain transfer agent for preparing the antibacterial polymer has a structure as described in the specification. In the formula, R is as defined in the specification. The preparation method for the chain transfer agent used for preparing the antibacterial polymer has the advantages that operation is simple, no toxic by-product is generated, and the price of synthesis raw materials is low; the polymer prepared from the chain transfer agent has a good bactericidal effect; and the chain transfer agent can be used as a lubricating oil additive and has good anti-wear and anti-friction effects.

Description

technical field [0001] The invention belongs to the field of chemical synthesis, and in particular relates to a chain transfer agent for preparing antibacterial polymers and a preparation method thereof. Background technique [0002] RAFT polymerization is based on the addition of the propagating free radical to the double bond of the compound containing -S-C=S structure, and the S-C bond is broken to introduce a reversible chain transfer reaction to realize the active growth of the polymer chain, so it is called reversible addition-break chain Transfer radical polymerization; the biggest advantage of RAFT is that it is applicable to a wide range of monomers. In addition to common monomers, acrylic acid, sodium p-vinylbenzenesulfonate, hydroxyethyl methacrylate, aminoethyl methacrylate and other protic Monomers or acidic and basic monomers can be polymerized smoothly, which is very beneficial to the polymerization of ethylenic monomers containing special functional groups; t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D263/32C08F2/38C08F120/54A01N47/06A01P1/00C10M135/14C10N30/06
CPCC07D263/32C08F2/38C08F120/54A01N47/06C10M135/14C10M2219/09
Inventor 吴张峰陈继云
Owner 吴张峰
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