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A tumor vessel normalization detection system and detection method

A tumor blood vessel and detection system technology, applied in the tumor blood vessel normalization detection system and detection field, can solve the problems of difficult to guarantee accuracy, complicated operation, limited application, etc., and achieve the effect of accurate judgment and prediction

Active Publication Date: 2022-05-20
WUHAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, due to the high cost and complicated operation of these methods, the accuracy is difficult to guarantee, which greatly limits their application in research.

Method used

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  • A tumor vessel normalization detection system and detection method
  • A tumor vessel normalization detection system and detection method
  • A tumor vessel normalization detection system and detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] [Example 1] Tumor blood vessel normalization detection system

[0070] The system and method for detecting normalization of tumor blood vessels according to the embodiments of the present invention. refer to figure 1 As shown, the system consists of a laser light source module, an imaging module, an image processor, a blood flow detection and analysis module, a blood vessel morphology analysis module, an artificial intelligence analysis module and a display module.

[0071] The laser light emitted by the He-Ne laser is firstly attenuated by a variable attenuator, then the beam diameter and divergence angle of the laser are changed by a beam expander, and finally the laser is evenly irradiated to the surface of tumor tissue by a reflector. The light reflected by the tumor tissue is magnified by a stereo microscope and collected by a CCD camera. The CCD camera transmits the collected speckle images to the blood flow detection and analysis module for blood flow image rec...

Embodiment 2

[0106] [Example 2] In a lung cancer xenograft model, the vascular normalization detection device guides Melafolone to enhance the efficacy of anti-PD-1 therapy

[0107] (1) Grouping and handling of animals

[0108] Mouse lung cancer cells LLC and CMT167 (5×10 6 ) were subcutaneously inoculated into C57BL / 6 mice. The tumor-bearing mice were randomly divided into blank control group, PD-1 monoclonal antibody group, Melafolone (Mel, which can induce normalization of tumor blood vessels) group, PD-1 monoclonal antibody and Mel combination group.

[0109] (2) Experimental detection

[0110] 1. Record the survival rate: observe the survival of the mice every day, and make a survival curve.

[0111] 2. Determination of tumor weight: The animals were sacrificed 24 hours after the last administration, the tumor was completely stripped off, the color and texture of the tumor tissue samples were observed, and the tumor weight was weighed with an electronic balance to calculate the tum...

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Abstract

The invention discloses a tumor vessel normalization detection system and detection method, the system comprising: a laser light source module, an imaging module, an image processor, a blood flow detection and analysis module, a blood vessel morphology analysis module, an artificial intelligence analysis module and a display module The blood flow detection and analysis module is used to obtain the blood flow velocity image, and the speckle image is processed into the blood flow velocity image through an algorithm; the vascular morphology analysis module is used to extract the tumor vascular morphological structure, and to analyze the tumor vascular density and the degree of vascular distortion Measurement; artificial intelligence analysis module, which is used to comprehensively evaluate tumor blood flow velocity, blood vessel density, and degree of distortion, determine whether tumor blood vessels are normalized, and give the prediction results of the normalization window period of tumor blood vessels. By imaging the structure and function of tumor blood vessels, the present invention can evaluate whether the tumor blood vessels are in the normalization window period, improves the clinical status of anti-tumor angiogenesis therapy, and provides a basis for formulating a more reasonable anti-tumor combined treatment plan.

Description

technical field [0001] The invention relates to the technical field of artificial intelligence detection of normalization of tumor blood vessels, in particular to a detection system and method for normalization of tumor blood vessels. Background technique [0002] With the change of people's lifestyle and the pollution of living environment, the incidence of tumor diseases is getting higher and higher. Tumor has become a common disease that seriously endangers human health and life. According to the "Global Cancer Statistics 2018" report, it is estimated that there will be 18.1 million new cancer cases and 9.7 million cancer deaths worldwide in 2018. By the end of this century, cancer will become the world's number one "killer" and also the biggest "blocker" hindering the extension of human life expectancy. According to the latest statistics, China accounts for nearly 20% of the world's malignant tumor patients and nearly 24% of the world's deaths. The incidence rate and m...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/00A61B5/026A61B5/1455G06T7/00G06T7/11G06T7/136
CPCA61B5/0059A61B5/0077A61B5/0261A61B5/1455G06T7/0004G06T7/11G06T7/136G06T2207/10056G06T2207/20024G06T2207/30024G06T2207/30101G06T2207/30096
Inventor 汪洋刘立龙陈亚昕陈雪寒袁茜杨静
Owner WUHAN UNIV