Continuous Production Process of Diphenylacetone

Abstract

The invention belongs to the technical field of organic synthesis, and in particular relates to a continuous production process of metaphenylacetone. Firstly, under a nitrogen protective atmosphere and an anhydrous dry environment, the Grignard reagent was prepared by using chlorobenzene, tetrahydrofuran and magnesium chips, and then the Grignard reagent was transferred to the Grignard reactor to react with lactate, and the reaction solution generated by the reaction was transferred to Quenching is carried out in a quenching kettle filled with dilute hydrochloric acid solution. After the reaction is completed, stand still for liquid separation. The separated organic phase is post-treated, and sulfuric acid is added for high-temperature dehydration. The upper layer product was recrystallized from methanol to obtain partial diphenylacetone. The preparation process realizes the continuous and industrialized production of the partial diphenylacetone, produces less three wastes, the solvent can be reused after being recovered, and the yield and purity of the prepared partial diphenylacetone are high.

Description

technical field [0001] The invention belongs to the technical field of organic synthesis, and in particular relates to a continuous production process of metaphenylacetone. Background technique [0002] The pure product of metadiphenylacetone is a colorless solid, and the industrial product is a yellow crystal. It can be used as an intermediate in the production of anticoagulant rodenticides, diquatine sodium salt, dirabatine and chlortetramone, and can also be used as a pharmaceutical intermediate for prostaglandin I2 agonists. body. [0003] Existing partial diphenylacetone synthetic route has following several kinds: [0004] 1. Starting from acetone, one-time chlorination produces monochloroacetone, and then secondary chlorination produces 1,1,1-trichloroacetone, and 1,1,1-trichloroacetone is reduced to obtain 1,1,1-trichloroacetone Chloroisopropanol, followed by phenylation to produce diphenylacetone; the reaction scheme for this method is as follows: [0005] [...

AI Technical Summary

Problems solved by technology

The recrystallization process is cumbersome and complicated, and sulfuric acid needs to be added a large amount of liquid caustic soda for neutralization reaction during the reaction process, resulting in a large amount of wastewater, which increases the pressure of wastewater treatment

[0019] In summary, the above method is only suitable for the synthesis of diphenylacetone in the laboratory, the process flow is complex, the synthesis route is long, the requirements for production equipment are high, the waste water and waste gas produced are large, and continuous production cannot be realized

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