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Hair growing oil and preparation method thereof

A growth factor and oily liquid technology, applied in the field of hair tonic and its preparation, can solve the problems of difficult biological activity, poor stability, and difficult hair growth effect

Active Publication Date: 2020-11-06
WENZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this kind of liniment for external use needs to be administered through the skin, and the epidermis, especially the stratum corneum, is the main barrier layer of the skin. Studies have found that only a small number of drugs can enter the skin, and the stability is poor, and the biological activity is difficult to maintain for a long time, resulting in This kind of liniment is difficult to play a good hair growth effect

Method used

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  • Hair growing oil and preparation method thereof
  • Hair growing oil and preparation method thereof
  • Hair growing oil and preparation method thereof

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preparation example Construction

[0033] The present invention also provides the preparation method of the hair growth oil described in the above technical solution, comprising the following steps:

[0034] (1) geranic acid and choline are mixed to carry out metathesis reaction to obtain ionic liquid;

[0035] (2) drying the ionic liquid obtained in the step (1) to obtain an oily liquid;

[0036] (3) mixing keratinocyte growth factor and PBS buffer to obtain growth factor solution;

[0037] (4) mixing the oily liquid obtained in the step (2) with the growth factor solution obtained in the step (3) to obtain hair growth oil;

[0038] The steps (1)-(2) and step (3) are not in order.

[0039] In the present invention, geranic acid and choline are mixed to carry out metathesis reaction to obtain ionic liquid. In the present invention, the mixing of geranic acid and choline is preferably carried out under stirring conditions. The present invention does not have a special limitation on the stirring time, as long...

Embodiment 1

[0047] (1) get 48.195wt% geranic acid (purity of 90%) and 29.076wt% choline in a round-bottomed flask and stir at room temperature until no carbon dioxide gas is generated to obtain an ionic liquid;

[0048] (2) vacuum drying the ionic liquid obtained in step (1) at 60° C. for 48h to obtain an oily liquid;

[0049] (3) Dissolving 0.005wt% KGF-2 in 22.724wt% PBS buffer to obtain a growth factor solution;

[0050] (4) uniformly mixing the oily liquid obtained in the step (2) and the growth factor solution obtained in the step (3) to obtain a hair growth oil.

Embodiment 2

[0052] (1) get 48.197wt% geranic acid (purity of 90%) and 29.077wt% choline in a round-bottomed flask and stir at room temperature until no carbon dioxide gas is generated to obtain an ionic liquid;

[0053] (2) vacuum drying the ionic liquid obtained in step (1) at 60° C. for 48h to obtain an oily liquid;

[0054] (3) Dissolving 0.001wt% KGF-2 in 22.725wt% PBS buffer to obtain a growth factor solution;

[0055] (4) uniformly mixing the oily liquid obtained in the step (2) and the growth factor solution obtained in the step (3) to obtain a hair growth oil.

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Abstract

The invention provides hair growing oil. The hair growing oil is prepared from the following components in percentage raw material: 45 to 50 weight percent of geranic acid, 25 to 32 weight percent ofcholine, 20 to 25 weight percent of PBS buffer solution and 0.001 to 0.1 weight percent of keratinocyte growth factor. The proportion of the geranic acid and the choline is adjusted, the geranic acidand the choline serve as carriers of the keratinocyte growth factors, the permeability of the skin can be improved, a relatively stable ion environment is provided in cooperation with the PBS buffer solution, the keratinocyte growth factors penetrate through the skin, and the activity of the keratinocyte growth factors is guaranteed; the proliferation and differentiation of hair follicle stem cells and hair mother cells are further stimulated, so that the hair follicle regeneration and maturation are promoted, and the hair growth is realized. The result of the embodiment shows that the hair growing oil provided by the invention is uniformly applied to the skin of an adult black mouse with shaved back hair, and most of the shaved part recovers to the length and density before being shaved within three weeks.

Description

technical field [0001] The invention belongs to the technical field of daily cosmetics, and particularly relates to a hair tonic and a preparation method thereof. Background technique [0002] Seborrheic alopecia, the scientific name is androgenetic alopecia, accounts for about 90% of hair loss patients. The speed and range of hair loss in seborrheic alopecia vary from person to person. Some only have mild baldness, or can last for many years. It can also reach the level of senile baldness in just a few years, and generally progresses fastest around the age of 30. In our country, anti-hair loss products are included in the scope of special product production license management. This series of reasons has led to slow progress in research on hair loss in the past few decades. [0003] The current drug for hair loss is minoxidil liniment, which is applied to the affected area of ​​the head. After being absorbed by the scalp, it can expand the blood vessels under the scalp, imp...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/36A61K8/41A61K8/24A61K8/20A61Q7/00A61P17/14
CPCA61K8/64A61K8/361A61K8/416A61K8/24A61K8/20A61Q7/00A61P17/14A61K2800/592A61K2800/805Y02P20/54
Inventor 何华成吴疆廖雨萍黄文齐巧玉安颖
Owner WENZHOU UNIVERSITY
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