Use of berberine in treatment or prevention of non-infectious ocular surface inflammation

A non-infectious, berberine technology, applied in the field of treatment or prevention of non-infectious ocular surface inflammation, berberine, can solve problems affecting the efficacy of treatment

Pending Publication Date: 2020-11-27
XIAMEN UNIV
View PDF10 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, tacrolimus is difficult to dissolve in the hydrophilic

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Use of berberine in treatment or prevention of non-infectious ocular surface inflammation
  • Use of berberine in treatment or prevention of non-infectious ocular surface inflammation
  • Use of berberine in treatment or prevention of non-infectious ocular surface inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] formula:

[0066]

[0067] Preparation Process:

[0068] 1. Accurately weigh 2.00g of berberine hydrochloride, 0.03g of benzalkonium chloride, 8.30g of sodium chloride, 30mL of 0.1mol / L hydrochloric acid, add 200mL of water for injection to dissolve, stir evenly, and dilute to 2000mL with water for injection to obtain liquid medicine.

[0069] 2. Filter the above solution once through a 0.45 μm microporous membrane, and then twice through a 0.22 μm microporous membrane.

[0070] 3. In a grade A environment, fill 5.0mL of the above liquid medicine into a 5mL single-dose packaging plastic container and seal it to obtain the finished product.

Embodiment 2

[0072] formula:

[0073]

[0074]

[0075] Preparation Process:

[0076] 1. Accurately weigh 2.00g of berberine hydrochloride, add 300mL of water for injection to dissolve it, and obtain solution ① for later use.

[0077] 2. Accurately weigh 0.05g of chlorhexidine acetate, 7.20g of sodium dihydrogen phosphate, 0.95g of disodium hydrogen phosphate, and 4.79g of sodium chloride, add 200mL of water for injection to dissolve them, stir and mix them evenly, and obtain the solution ② for later use .

[0078] 3. Mix solution ① and solution ②, stir evenly, and dilute to 1000mL with water for injection to obtain a medicinal solution.

[0079] 4. Filter the above medicinal solution once through a 0.45 μm microporous membrane, and then twice through a 0.22 μm microporous membrane.

[0080] 5. In a grade A environment, fill 5.0mL of the above liquid medicine into a 5mL single-dose packaging plastic container and seal it to obtain the finished product.

Embodiment 3

[0082] formula:

[0083]

[0084] Preparation Process:

[0085] 1. Accurately weigh 2.00g berberine hydrochloride, 0.03g benzalkonium bromide, 6.40g sodium dihydrogen phosphate, 1.89g disodium hydrogen phosphate, 4.72g sodium chloride, 0.10g disodium edetate, add 200mL Dissolve in water for injection, stir evenly, and dilute to 1000mL with water for injection to obtain a medicinal solution.

[0086] 2. Filter the medicinal solution prepared above through a 0.45 μm microporous membrane once, and then through a 0.22 μm microporous membrane once.

[0087] 3. The filtered liquid medicine is sterilized at 121° C. for 8 minutes by autoclaving, and then cooled.

[0088] 4. In a grade A environment, fill 5.0mL of the above liquid medicine into a 5mL single-dose packaging plastic container and seal it to obtain the finished product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to use of berberine, a stereisomer thereof, pharmaceutically acceptable salt thereof, a pharmaceutically acceptable hydrate thereof or a pharmaceutically acceptable solvate thereof in preparation of drugs, wherein the drugs are used for treating or preventing and inhibiting non-infectious ocular surface inflammation, promoting repairing of ocular surface tissues, increasing conjunctival goblet cells and promoting secretion of tear and/or maintaining the stability of tear films. The berberine locally applied to the ocular surface is capable of inhibiting the non-infectiousocular surface inflammation, promoting the repairing of the ocular surface tissues and increasing the conjunctival goblet cells and has relatively good effects of promoting the secretion of the tearand maintaining the stability of the tear films.

Description

technical field [0001] The invention relates to the field of medicinal chemistry, in particular to the use of berberine in the treatment or prevention of non-infectious ocular surface inflammation. Background technique [0002] Non-infectious ocular surface inflammation is inflammation of the ocular surface caused by non-infectious causes such as immune and metabolic diseases and chemical substances, including dry eye, meibomian gland dysfunction, blepharitis, blepharitis, corneal chemical injury, Ocular surface diseases such as allergic conjunctivitis, Stevens-Johnson syndrome, allergic conjunctivitis, giant papillary conjunctivitis, vernal conjunctivitis, atopic keratoconjunctivitis, pterygium, Mooren corneal ulcer, scleritis, and episcleritis And various types of uveal inflammation. Their common feature is persistent ocular surface inflammation caused by non-infectious factors. Chronic inflammation plays a key role in causing ocular surface damage, and effective and sa...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/4375A61P27/02A61P29/00
CPCA61K31/4375A61P27/02A61P29/00
Inventor 刘祖国韩忆
Owner XIAMEN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap