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Application of fibroblast growth factor FGF21 to preparation of drug for treating skin ultraviolet injury

A technology of FGF21 and fibroblasts, applied in skin diseases, drug combinations, medical preparations containing active ingredients, etc., can solve the problem of lack of drugs for skin damage

Active Publication Date: 2020-12-04
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is in order to solve the problem that lacks the medicine that treats UVB to cause skin damage, provides fibroblast growth factor FGF21 in the medicine of preparation treatment skin ultraviolet damage application

Method used

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  • Application of fibroblast growth factor FGF21 to preparation of drug for treating skin ultraviolet injury
  • Application of fibroblast growth factor FGF21 to preparation of drug for treating skin ultraviolet injury
  • Application of fibroblast growth factor FGF21 to preparation of drug for treating skin ultraviolet injury

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specific Embodiment approach 1

[0026] Embodiment 1: The application of fibroblast growth factor FGF21 in the preparation of a drug for treating skin ultraviolet damage according to this embodiment.

[0027] FGF21 can protect skin tissue against damage caused by UVB. At the same time, Hoechst 33342 staining in vitro showed that UVB induced nuclear hyperchromatism, but this effect was reversed by administration of FGF21. This suggests that FGF21 protects skin tissue and inhibits apoptosis. Apoptosis mainly has two pathways: mitochondria and death receptors, among which Caspase-3 is an apoptosis execution protein, and inhibiting its activation can effectively resist UVB-induced apoptosis. In vitro experiments found that FGF21 can effectively inhibit the activation of caspase-3 induced by UVB in both epidermal cells and dermal cells. This suggests that FGF21 protects skin tissue by inhibiting apoptosis, and the above mechanism is different from the existing mechanism of FGF repairing tissue damage.

specific Embodiment approach 2

[0028] Embodiment 2: The difference between this embodiment and Embodiment 1 is that FGF21 is used to improve the survival rate of human epidermal cells HacaT after UVB irradiation. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0029] Embodiment 3: This embodiment differs from Embodiment 1 or Embodiment 2 in that: FGF21 inhibits the apoptosis of human epidermal cells HacaT after UVB irradiation by inhibiting the activation of UVB-induced apoptosis executive protein Caspase-3. Others are the same as those in Embodiment 1 or 2.

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Abstract

The invention relates to application of a fibroblast growth factor FGF21 to preparation of a drug for treating skin ultraviolet injury. The invention aims to solve the problem that a drug for treatingthe skin injury caused by UVB lacks, and provides the application of the fibroblast growth factor FGF21 to the preparation of the drug for treating the skin ultraviolet injury. According to the application of the fibroblast growth factor FGF21 to the preparation of the drug for treating the skin ultraviolet injury, the FGF21 can improve the survival rate of human epidermal cells (HacaT) and dermal fibroblast cells (NIH3T3) after suffering from UVB irradiation, and meanwhile, it is found that the action mechanism of the FGF21 is related to inhibition of apoptosis of cells. The invention is applicable to the field of biological pharmacy.

Description

technical field [0001] The invention relates to the application of fibroblast growth factor FGF21 in the preparation of medicine for treating skin ultraviolet damage. Background technique [0002] As one of the components of sunlight, UVB has a wavelength range of 280-315nm. Long-term or short-term exposure to large amounts of UVB can cause skin inflammation, photoaging and even the risk of cancer, so UVB has always been the focus of people's prevention. There are differences in the effects of UVB exposure on the skin. For epidermal cells, UVB irradiation mainly induces apoptosis. For dermal cells, on the one hand, UVB irradiation causes dermal cells to release inflammatory factors, and then induces and activates immune cells to migrate to the damaged site, eventually causing skin inflammation; on the other hand, UVB irradiation can also inhibit the ability of dermal fibroblasts to synthesize collagen. At the same time, the increase in the activity of matrix metalloprotei...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P17/16
CPCA61K38/1825A61P17/16
Inventor 赵叶利林丽叶莎莎林静静王雪王鹏
Owner WENZHOU MEDICAL UNIV
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