Pharmaceutical composition and application thereof in preparation of drugs for preventing and/or treating Alzheimer's disease
A technology for Alzheimer's disease and a composition, applied in the field of biopharmaceuticals, can solve the problem that the value of anthocyanins has not been fully developed, and achieve the effects of preventing neuronal cell necrosis, improving learning and memory ability, and increasing the number of crossing platforms
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Embodiment 1
[0029] Embodiment 1 Experimental design
[0030] The experimental subjects were SAMR1 and SAMP8 mice, SPF grade, male, 4 months old, body weight 30g±2g, among which 10 SAMR1 mice and 50 SAMP8 mice were equally divided into 5 groups. The experiment began after one week of adaptive feeding of the experimental animals. Each mouse was reared in a single cage, free to eat and drink, the light setting was 12 hours in the daytime and 12 hours in the dark, the indoor temperature was 20±2°C, and the relative humidity was 55%±5%. The daily treatment of each experimental group is as follows:
[0031] Normal group: SAMR1 mice were the normal group (coded as SAMR1), fed with sterile water;
[0032] Model group: a group of SAMP8 mice were randomly selected as the model group (coded as SAMP8), and sterilized water was administered to the stomach;
[0033] Donepezil group: Randomly select a group of SAMP8 mice to give the positive drug donepezil (coded as Donepezil), and administer 1 mg / kg ...
Embodiment 2
[0038] Embodiment 2 water maze experiment
[0039] The direction and learning and memory ability of the mice were evaluated by the water maze experiment. The experimental results of the number of times the mice in the water maze experiment of different treatment groups crossed the platform are as follows: figure 1 shown. The experimental results showed that compared with the model group, the metformin and cyanidin-3-O-galactoside group significantly increased the number of times the mice crossed the platform, improved the learning and memory ability of the mice, and were significantly better than the donepezil group, metformin group and sagittarius group. The cyanidin-3-O-galactoside group.
Embodiment 2Y
[0040] Embodiment 2Y maze experiment
[0041] The spontaneous alternating response rate and learning and memory ability of the mice were evaluated by the Y maze test. The experimental results of the spontaneous alternating response rate of the mice in the Y maze experiment of different treatment groups are as follows: figure 2 shown. The experimental results showed that compared with the model group, the metformin and cyanidin-3-O-galactoside group could significantly increase the rate of spontaneous alternation and improve the learning and memory ability of the mice, and it was significantly better than the donepezil group, metformin group and sagittarius group. The cyanidin-3-O-galactoside group.
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