Medical water-based adhesive and method of use thereof
A water-based, medical technology, applied in the field of medical water-based adhesives and medical adhesives, which can solve the problems of inconvenient use and lack of scientific evidence.
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[0026] Such as figure 1 As shown, the preparation method of the medical water-based adhesive provided by the present invention includes the following steps: step 1 obtains mucus from the skin of a living giant salamander, and freeze-dries the mucus; step 2 pulverizes the freeze-dried mucus in a frozen state to obtain a particle size Powder less than 1000 μm; Step 3: Sterilize the powder to obtain freeze-dried powder of giant salamander skin mucus; The weight ratio is mixed to form a medical water-based adhesive.
[0027] The method of collecting mucus in step 1 should be carried out in strict accordance with China's animal protection law, without killing the giant salamander and without causing permanent disability of the giant salamander. Scratching method or electrical stimulation method can be used, which is not limited in the present invention.
[0028] In step 2, the collected giant salamander skin mucus is freeze-dried, pulverized by a ball mill at a low temperature an...
Embodiment 1
[0033] Example 1: Preparation of medical water-based viscose and analysis of swelling rate
[0034] The preparation of the medical water-based adhesive of the present invention adopts the weight ratio of the freeze-dried powder of giant salamander skin mucus to the aqueous solution of 1:2 to 1:6, that is, 1 part of the freeze-dried powder of giant salamander skin mucus and 2 to 6 parts by weight of The medical water-based adhesive is obtained after the aqueous solution is mixed.
[0035] When the giant salamander skin mucus freeze-dried powder is mixed with an aqueous solution, the polypeptide cross-linked network expands rather than dissolves, and after mixing, the entangled protein network driven by hydrogen bonds in the giant salamander skin mucus freeze-dried powder is changed to form a gel. This process is called into glue. During the gelation process, the amino acid residues of the polypeptide chain undergo a conformational transformation to form a gel-like adhesive, an...
Embodiment 2
[0043] Embodiment 2: Structural analysis of medical water-based adhesive of the present invention
[0044] The medical water-based adhesive provided by the invention has a porous structure after being gelled, so that it can facilitate the exchange of nutrients and metabolites in interstitial fluid during clinical application.
[0045] Analyze the porous structure of the medical water-based adhesive obtained in Example 1 of the present invention with a scanning electron microscope (Hitachi, S-3400N II, Japan), as Figure 3A shown. The freeze-dried powder of giant salamander skin mucus formed after the freeze-drying of giant salamander skin mucus is a white powder, which is shown as uneven lumps by scanning electron microscope analysis. However, when the lyophilized powder of giant salamander skin mucus was mixed with an aqueous solution, the polypeptide chains in the clumps would expand and interpenetrate to form a medical water-based adhesive with a three-dimensional honeycom...
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