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Liquid dressing and preparation method thereof

A technology of liquid dressing and sodium hyaluronate, applied in medical science, bandages and other directions, can solve the problems of lack of moisturizing ingredients, unfavorable wound recovery, etc., and achieve the effects of reducing irritation and sensitization risks, simple preparation method and low cost.

Pending Publication Date: 2020-12-22
西安博和医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent CN108671264 A discloses a hemostatic body dressing for body surface trauma, using fatty alcohol polyoxyethylene ether sodium sulfate, β-glucose, and benzalkonium bromide to play the role of hemostasis and antibacterial, but this technical solution only uses water as a solvent, lacking Moisturizing ingredients, not conducive to wound recovery

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A liquid dressing, comprising the following components by mass percentage: 8% glycerin, 3% polyethylene glycol 400, 0.05% macromolecular sodium hyaluronate, 0.08% low molecular weight sodium hyaluronate, hydrolyzed sodium hyaluronate 0.1%, trehalose 0.5%, methylparaben 0.1%, phenoxyethanol 0.2%, ethylparaben 0.05%, purified water to make up the balance.

[0023] The preparation steps of the liquid dressing are:

[0024] 1) Disperse macromolecular sodium hyaluronate, low molecular weight sodium hyaluronate and hydrolyzed sodium hyaluronate with glycerin, and after the dispersion is uniform, dispersion A is obtained;

[0025] 2) Add polyethylene glycol and trehalose to the dispersion A prepared in step 1) in sequence, and stir evenly to obtain a mixture B;

[0026] 3) Heat the purified water to 90°C and keep it warm for 10 minutes. When the temperature of the purified water drops to 70°C, add the mixed solution B and stir evenly. When the temperature drops to 40°C, disch...

Embodiment 2

[0028] A liquid dressing, comprising the following components by mass percentage: 6% glycerin, 3% polyethylene glycol 400, 0.08% macromolecular sodium hyaluronate, 0.1% low molecular weight sodium hyaluronate, hydrolyzed sodium hyaluronate 0.3%, trehalose 0.5%, methylparaben 0.05%, phenoxyethanol 0.15%, ethylparaben 0.15%, purified water to make up the balance.

[0029] The preparation steps of the liquid dressing are:

[0030] 1) Disperse macromolecular sodium hyaluronate, low molecular weight sodium hyaluronate and hydrolyzed sodium hyaluronate with glycerin, and after the dispersion is uniform, dispersion A is obtained;

[0031] 2) Add polyethylene glycol and trehalose to the dispersion A prepared in step 1) in sequence, and stir evenly to obtain a mixture B;

[0032] 3) Heat the purified water to 90°C and keep it warm for 10 minutes. When the temperature of the purified water drops to 75°C, add the mixed solution B and stir evenly. When the temperature drops to 40°C, disc...

Embodiment 3

[0034] A liquid dressing, comprising the following components by mass percentage: glycerin 5%, polyethylene glycol 400 2%, macromolecular sodium hyaluronate 0.01%, low molecular weight sodium hyaluronate 0.01%, hydrolyzed sodium hyaluronate 0.01%, trehalose 0.1%, ethylparaben 0.1%, purified water to make up the balance.

[0035] The preparation steps of the liquid dressing are:

[0036] 1) Disperse macromolecular sodium hyaluronate, low molecular weight sodium hyaluronate and hydrolyzed sodium hyaluronate with glycerin, and after the dispersion is uniform, dispersion A is obtained;

[0037] 2) Add polyethylene glycol and trehalose to the dispersion A prepared in step 1) in sequence, and stir evenly to obtain a mixture B;

[0038] 3) Heat the purified water to 90°C and keep it warm for 10 minutes. When the temperature of the purified water drops to 75°C, add the mixed solution B and stir evenly. When the temperature drops to 40°C, discharge the material to obtain the liquid dr...

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Abstract

The invention belongs to the field of medical dressings, and particularly relates to a liquid dressing and a preparation method thereof. The liquid dressing is prepared from glycerin, polyethylene glycol, sodium hyaluronate, trehalose and purified water. The liquid dressing prepared according to the technical scheme is safe and non-irritant, can protect a wound from being infected by external pollutants and bacteria, and meanwhile has effects of moisturizing and repairing wound skin.

Description

technical field [0001] The invention belongs to the field of medical dressings, in particular to a liquid dressing and a preparation method thereof. Background technique [0002] In daily work and life, superficial skin injuries often occur. However, traditional wound care products such as band-aids / gauze have shortcomings such as strong foreign body sensation, easy adhesion to the wound, and easy to fall off after being wet. Therefore, liquid wound dressings that are more convenient to use and better in user experience have become a research hotspot in recent years. [0003] Patent CN108721687 A discloses a compound repair solution, which is compounded by adding gradient hyaluronic acid solution, growth factor solution and plant extract solution to achieve the effects of skin repair, protection and care, but the added plant extract components pose a higher risk of sensitization. Patent CN108671264 A discloses a hemostatic body dressing for body surface trauma, using fatty...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0095A61L26/0066A61L2300/216A61L2300/404C08L5/08
Inventor 李飞艳
Owner 西安博和医疗科技有限公司
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