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Preparation method for small-size targeting laminar aluminosilicate drug loading platform, drug loading platform and application thereof

An aluminosilicate, small-scale technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve problems such as less research in the field of drug carriers, and achieve drug targets The effect of weak tropism, improved targeting, and good biocompatibility

Pending Publication Date: 2020-12-29
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In recent years, layered aluminosilicates have been widely used in the fields of batteries, silicon nanomaterials, textiles, and chemical adsorption, but less research has been done in the field of drug carriers.

Method used

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  • Preparation method for small-size targeting laminar aluminosilicate drug loading platform, drug loading platform and application thereof
  • Preparation method for small-size targeting laminar aluminosilicate drug loading platform, drug loading platform and application thereof
  • Preparation method for small-size targeting laminar aluminosilicate drug loading platform, drug loading platform and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038]Preparation of a small-size targeted layered aluminosilicate drug-loading platform

[0039]Step 1. Take 10 mg of layered aluminosilicate and add 50 mL of deionized water to dissolve it, and then filter with a 0.45 μm water phase filter to obtain a small-sized layered aluminosilicate mixed solution.

[0040]Step 2. After the above solution is allowed to stand for 12 hours, take 40 mL of the supernatant, add the anti-cancer drug doxorubicin to it to reach a concentration of 2 mg / mL, and magnetically stir for 4 hours at 70°C under dark conditions at a speed of 500r / min.

[0041]Step 3. After cooling to room temperature, after two centrifugal washing with water, a dark red precipitate is obtained.

[0042]Step 4. Add 6 mL of a folic acid solution with a concentration of 8 mg / L to the precipitation, and react for 3 hours under 500 r / min magnetic stirring to obtain a suspension solution.

[0043]Step 5. Finally, freeze-dry the suspension solution (temperature: -54° C., time: 24 h, vacuum degree: ...

Embodiment 2

[0046]Preparation of a small-size targeted layered aluminosilicate drug-loading platform

[0047]Step 1. Take 10 mg of layered aluminosilicate and add 50 mL of deionized water to dissolve it, and then filter with a 0.45 μm filter to obtain a small-sized layered aluminosilicate mixed solution.

[0048]Step 2. After leaving the above solution for 12 hours, take 40mL of the supernatant, add the anticancer drug doxorubicin to it to make the concentration reach 2mg / mL, and magnetically stir for 3 hours at 70°C and protected from light. The stirring speed is 500r / min.

[0049]Step 3. After cooling to room temperature, after two centrifugal washing with water, a dark red precipitate is obtained.

[0050]Step 4. Add 6 mL of a folic acid solution with a concentration of 8 mg / L to the precipitation, and react for 3 hours under 500 r / min magnetic stirring to obtain a suspension solution.

[0051]In step 5, it is finally freeze-dried (temperature: -54°C, time: 24h, vacuum degree: 8.7Pa) to obtain a small-size...

Embodiment 3

[0053]Preparation of a small-size targeted layered aluminosilicate drug-loading platform

[0054]Step 1. Take 10 mg of layered aluminosilicate and add 50 mL of deionized water to dissolve it, and then filter with a 0.45 μm filter to obtain a small-sized layered aluminosilicate mixed solution.

[0055]Step 2. After leaving the above solution for 12 hours, take 40 mL of the supernatant, add the anti-cancer drug doxorubicin to it to reach a concentration of 2 mg / mL, and magnetically stir for 6 hours at 70°C and protected from light. The stirring speed is 500r / min.

[0056]Step 3. After cooling to room temperature, after two centrifugal washing with water, a dark red precipitate is obtained.

[0057]Step 4. Add 6 mL of a folic acid solution with a concentration of 8 mg / L to the precipitation, and react for 3 hours under 500 r / min magnetic stirring to obtain a suspension solution.

[0058]In step 5, it is finally freeze-dried (temperature: -54°C, time: 24h, vacuum degree: 8.7Pa) to obtain a small-size ...

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Abstract

The invention discloses a preparation method for a small-size targeting laminar aluminosilicate drug loading platform, the drug loading platform and application thereof. The preparation method comprises the steps of dissolving laminar aluminosilicate in deionized water, carrying out filtering so as to obtain a mixed solution of the laminar aluminosilicate, carrying out standing, then, taking out supernatant, adding an anti-cancer drug into the supernatant, carrying out stirring under shaded conditions, then, carrying out centrifugation washing so as to obtain precipitates, adding a folic acidsolution into the precipitates, carrying out stirring so as to obtain a suspension, and finally, subjecting the suspension to freeze drying, thereby obtaining the small-size targeting laminar aluminosilicate drug loading platform. According to the small-size targeting laminar aluminosilicate drug loading platform prepared by the preparation method, small-size laminar aluminosilicate has good biocompatibility, the surface of the small-size laminar aluminosilicate is bonded to folic acid, and thus, the small-size laminar aluminosilicate can be more accurately bonded to a folic acid acceptor on tumor cells; and the drug loading platform can stably release adriamycin and is excellent in antitumor effect, and in-vivo toxic or side effects of the drug are lowered. Simultaneously, the drug loading platform disclosed by the invention is simple in synthesis process, and thus, actual operations are simple and efficient.

Description

Technical field[0001]The invention belongs to the technical field of anti-tumor layered nano materials, and specifically relates to a preparation method and application of a small-size targeted layered aluminosilicate drug-loading platform.Background technique[0002]Malignant tumor is currently one of the diseases with the highest mortality rate in the world, and the annual incidence is on the rise. More and more researchers around the world are devoted to the research of tumor treatment. At present, the effective methods for the treatment of malignant tumors mainly include surgical treatment, radiotherapy and chemotherapy.[0003]Chemotherapy usually uses anti-tumor drugs to treat patients. Doxorubicin belongs to the anthracycline class of broad-spectrum anti-tumor antibiotics. Its hydrochloride is commonly used clinically, which can produce a wide range of biological effects on the body. Adriamycin has a strong cytotoxic effect and has a good effect on liver cancer, thyroid cancer, l...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K47/02A61K47/22A61K31/704A61P35/00
CPCA61K9/5115A61K9/5123A61K31/704A61P35/00
Inventor 周宁琳张盼沈健孙宝宏李东辉楚晓红王玉丽张启成石绍泽王志轩
Owner NANJING NORMAL UNIVERSITY
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