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Hyaluronic acid composition with penetration promoting effect as well as preparation method and application thereof

A technology of hyaluronic acid and hydrolyzed hyaluronic acid, which can be applied in cosmetic preparations, skin care preparations, pharmaceutical formulations, etc., can solve the problem of hyaluronic acid composition promoting target active substances, and achieve excellent absorption speed, particle size Small diameter, the effect of promoting absorption

Pending Publication Date: 2021-01-08
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, there is currently no report on the use of hyaluronic acid compositions alone to promote target actives

Method used

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  • Hyaluronic acid composition with penetration promoting effect as well as preparation method and application thereof
  • Hyaluronic acid composition with penetration promoting effect as well as preparation method and application thereof
  • Hyaluronic acid composition with penetration promoting effect as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Accurately weigh 20g of sodium hyaluronate with a molecular weight of 400kDa, 10g of acetylated sodium hyaluronate with a molecular weight of 100kDa, and 70g of hydrolyzed sodium hyaluronate with a molecular weight of 18kDa. After mixing evenly, add 1000ml of purified water to make a 10% Aqueous solution is processed by spray drying. Set the feed temperature to 125°C, the discharge temperature to 90°C, and the atomizer frequency to 40 Hz to obtain uniform fine powder.

Embodiment 2

[0111] Accurately weigh 30g of sodium hyaluronate with a molecular weight of 250kDa, 30g of acetylated sodium hyaluronate with a molecular weight of 30kDa, and 40g of hydrolyzed sodium hyaluronate with a molecular weight of 10kDa. After mixing evenly, add 2000ml of purified water to make a 5% Aqueous solution is processed by spray drying. Set the feed temperature to 125°C, the discharge temperature to 90°C, and the atomizer frequency to 40 Hz to obtain uniform fine powder.

Embodiment 3

[0113] Accurately weigh 35g of sodium hyaluronate with a molecular weight of 280kDa, 25g of acetylated sodium hyaluronate with a molecular weight of 25kDa, and 40g of hydrolyzed sodium hyaluronate with a molecular weight of 8kDa. After mixing evenly, add 3000ml of purified water to make 3.33% Aqueous solution is processed by spray drying. Set the feed temperature to 125°C, the discharge temperature to 90°C, and the atomizer frequency to 40 Hz to obtain uniform fine powder.

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Abstract

The invention discloses a hyaluronic acid composition with a penetration promoting effect as well as a preparation method and application thereof. The invention provides the hyaluronic acid composition comprising hyaluronic acid or a salt thereof, acetylated hyaluronic acid or a salt thereof, and hydrolyzed hyaluronic acid or a salt thereof. According to the hyaluronic acid composition with the penetration promoting effect as well as the preparation method and the application thereof, the hyaluronic acid composition is small in addition amount, capable of effectively promoting absorption of other effective components in a formula and achieving a synergistic effect, small and uniform in particle size, high in dissolving speed and excellent in absorption speed in a product, is superior to hyaluronic acid treated by a simple mixing mode in the aspect of improving the hydration degree of skin, compared with a traditional penetration enhancer, the hyaluronic acid composition has no damage to the skin and is safe.

Description

technical field [0001] The invention relates to the technical field of hyaluronic acid, in particular to a hyaluronic acid composition with an effect of promoting penetration, a preparation method and an application thereof. Background technique [0002] From ancient times to the present, beauty is the eternal pursuit of people, especially women. With age, dull, dry, sagging, sagging, and wrinkled skin plague all people. Therefore, most young people know It is understood that if you want to maintain the skin's youthful characteristics such as moisture, fairness, elasticity, and water-oil balance, you should take skin care as soon as possible to delay the aging speed of the skin. [0003] The skin is the largest organ in the human body, with an average adult skin surface area of ​​about 1.6m 2 , the total weight accounts for about 16% of the body weight. The skin is divided into three parts: the epidermis, the dermis and the subcutaneous tissue from the outside and the insid...

Claims

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Application Information

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IPC IPC(8): A61K8/73A61Q19/00A61L26/00
CPCA61K8/735A61Q19/00A61L26/0023A61L26/008A61L26/0061C08L5/08A61K31/122A61K31/195A61L26/0066A61K31/728A61K31/05A61Q19/08A61K8/44A61K8/35A61K47/36A61K2800/10A61L2300/214A61L2300/216
Inventor 王玉玲郭学平吕慧侠乔莉苹任姝静温喜明李霞王静耿凤
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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