Degradable filling composition for tooth extraction wounds and preparation method and use of degradable filling composition

A technology of filling composition and tooth extraction wound, which is applied in the field of biomedical materials for oral care, which can solve the problems of unstable tooth extraction socket, short action time, and poor plasticity, and achieve no need for pressing, small foreign body sensation, and good plasticity Effect

Active Publication Date: 2021-01-08
诺一迈尔(山东)医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] In order to solve the technical problem of short action time caused by the poor plasticity and good water solubility of the existing tooth extraction socket filling compo

Method used

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  • Degradable filling composition for tooth extraction wounds and preparation method and use of degradable filling composition
  • Degradable filling composition for tooth extraction wounds and preparation method and use of degradable filling composition
  • Degradable filling composition for tooth extraction wounds and preparation method and use of degradable filling composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029]The degradable dental extraction wound filling composition includes the following raw materials by weight: 6g calcium stearate, 3g alginic acid / chitosan complex, 2g bioactive glass, and 6g tocopherol acetate;

[0030]The preparation method of the degradable tooth extraction wound filling composition: weigh the components according to the formula, mechanically mix the dry solid components, and gradually add the liquid component tocopherol acetate after mixing, mix mechanically at room temperature, and treat to a uniform putty Shape, that is, a degradable tooth extraction wound filling composition is obtained. Physical imagefigure 1As shown, the degradable dental extraction wound filling composition of this embodiment can be arbitrarily shaped and deformed in the tooth socket, and can fully fill, especially the irregular tooth socket.

[0031]The preparation method of the alginic acid / chitosan complex in this embodiment is as follows: Dissolve 0.1g sodium alginate and 3.0g chitosan in...

Embodiment 2

[0034]The degradable dental extraction wound filling composition includes the following raw materials by weight: 5g calcium stearate, 4g alginic acid / chitosan complex, 2g bioactive glass, 5g tocopherol acetate, 1g poloxamer (Pluronic L35);

[0035]The preparation method of the degradable tooth extraction wound filling composition is the same as in Example 1.

[0036]The preparation method of the alginic acid / chitosan complex in this example is the same as that of Example 1.

[0037]The bioactive glass in this example is the same as in example 1.

[0038]The physical characteristics of the composition obtained in this example are similar to those of the composition of Example 1, but the water resistance of Example 1 is weakened, the swelling time is shortened, and the viscosity of the composition of this example is increased.

[0039]The retention time of the composition in the extraction socket can be controlled by adjusting the amount of poloxamer in the formula. Poloxamer is used to adjust the s...

Embodiment 3

[0042]The degradable dental extraction wound filling composition includes the following raw materials by weight: 4g calcium stearate, 6g alginic acid / chitosan complex, 1g bioactive glass, and 6g tocopherol acetate;

[0043]The preparation method of the degradable dental extraction wound filling composition is the same as in Example 1.

[0044]The preparation method of the alginic acid / chitosan complex in this embodiment is as follows: prepare 20 mL of sodium alginate-acetic acid aqueous solution with a concentration of 0.3% pH=5 and 5 mL of chitosan-acetic acid aqueous solution with a concentration of 0.15% pH=5. Slowly drip the chitosan-acetic acid aqueous solution into the sodium alginate-acetic acid aqueous solution under ultrasonic conditions, and after stirring for 30 minutes, the sodium alginate / chitosan gel microspheres were precipitated, and the gel microspheres were obtained by centrifugation for 20 minutes. Glue microspheres are washed with water: washed with 30%, 70% and 100% e...

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Abstract

The present invention relates to a degradable filling composition for tooth extraction wounds and a preparation method and a use of the degradable filling composition. The degradable filling composition is characterized by comprising the following raw materials in parts by weight: 20-60 parts of calcium stearate, 10-40 parts of an alginic acid/chitosan compound, 5-30 parts of bioactive glass, 10-60 parts of tocopherol acetate and 0-30 parts of poloxamer. The preparation method comprises the following steps: mechanically and uniformly mixing the calcium stearate, alginic acid/chitosan compound,bioactive glass and poloxamer, then adding the tocopherol acetate, uniformly mixing the materials to form a muddy ash-shaped mixture, and shaping, packaging and sterilizing are conducted to obtain the degradable filling composition for the tooth extraction wounds. After tooth extraction, the composition is filled in the tooth extraction wounds to prevent complications of tooth extraction. The degradable filling composition for the tooth extraction wounds is a putty-shaped material which can be shaped and deformed at will, can be used for filling tooth extraction nests in any shapes, is also long in acting time, can also stabilize a hemostatic effect, and plays roles in repairing and inhibiting microorganisms at the same time.

Description

Technical field[0001]The invention relates to the technical field of biomedical materials for oral care, in particular to a degradable dental extraction wound filling composition and a preparation method and application thereof.Background technique[0002]In oral and maxillofacial surgery, tooth extraction is the most basic and most widely used operation. Like other operations, it can cause varying degrees of damage to local soft and hard tissues, causing bleeding, swelling, pain, infection and other symptoms and signs. The most common complications after bleeding after surgery, if not handled properly, can cause more serious complications. Compression method is currently the most commonly used clinical method for hemostasis of tooth extraction wounds. Usually, a cotton ball or gauze ball is placed on the tooth extraction wound and occluded for a period of time to achieve compression and hemostasis. However, this hemostasis method has certain risks. For example, cotton balls or gauze ...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/02A61L31/14A61L31/16A61L24/02A61L24/00A61L24/08
CPCA61L31/129A61L31/026A61L31/16A61L31/14A61L24/0015A61L24/0094A61L24/02A61L24/001A61L2400/04A61L2300/41A61L2300/418A61L2300/402
Inventor 李明郭刚孟洋王丽朱晓强
Owner 诺一迈尔(山东)医学科技有限公司
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