A method of directly using a razor blade to prepare a three-dimensional metal microneedle array

Abstract

A method for directly using a razor blade to prepare a three-dimensional metal microneedle array. First, a double-sided razor blade is used as a microneedle preparation blank, a clamping tool is processed, and the blades are alternately stacked in the groove of the clamping tool. Secondly, the blade is cut according to the shape and size of the microneedle array to obtain half-sheet or full-sheet microneedle sheets, and the processed microneedle sheets are taken out for use. Thirdly, design and process the three-dimensional microneedle array packaging fixture for half-chip and full-chip microneedle array packaging, put the microneedle sheet and gasket into the packaging structure at intervals, and obtain the three-dimensional microneedle array by bolt fastening. The invention makes full use of the structural characteristics of conventional razor blades, has fewer manufacturing procedures, low cost, high efficiency, sharp needle points, and is suitable for mass production; the designed processing tooling makes the blades stack alternately on the blade part, minimizing the gap between each blade. Clearance, improve processing accuracy; matching packaging structure is easy to use, easy to carry, detachable cleaning and disinfection, can be reused.

Description

technical field [0001] The invention belongs to the technical field of medical equipment and the field of mechanical processing, and relates to a three-dimensional metal microneedle array and a preparation method thereof. Background technique [0002] Oral administration, injection administration and transdermal administration are the three most commonly used administration methods at present, and each of these three delivery methods has advantages and disadvantages. For example, oral administration is very convenient to store, carry and use, but because the drug needs to pass through tissues and organs such as the gastrointestinal tract and liver, intestinal inactivation and the "first-pass effect" of the liver will cause part of the drug to be metabolized, and the absorption efficiency is greatly reduced. However, some drugs may cause side effects such as adverse stimulation to the stomach, thereby limiting the scope of application of oral administration, especially not su...

AI Technical Summary

Problems solved by technology

At present, metal microneedle processing methods are quite rich, including chemical etching, ultraviolet lithography, micro-milling, laser cutting, electroplating, etc., but these processing methods have the disadvantages of low processing accuracy, low processing efficiency and high cost, and it is difficult to meet the requirements of mass production. Production requirements

Our team once proposed a design and preparation method of a planar metal microneedle array based on wire cutting, which has the advantages of high efficiency, simple preparation, low cost, and controllable precision, and is suitable for mass production. However, the microneedles are cut from thin metal sheets. Therefore, the size along the thickness direction remains unchanged, and the needle tip can only be sharpened by changes in the width direction, which affects the overall sharpness of the microneedle tip, resulting in a relatively large force when the microneedle penetrates the skin, which is not conducive to full use. The advantages of microneedling are painless and minimally invasive

In addition, since the metal flakes used as raw materials are often large-sized, they need to be processed into small-sized flakes before use, which increases the process and cost

Images