Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of tea saponin thiosemicarbazone zinc complex and its preparation method and application

The technology of aglycone peptide amino and zinc complex is applied in the field of medicine, and can solve the problems of only considering antibacterial activity, no report on research, and no consideration of immune function regulation effect, etc., and achieves improvement of immune enhancement effect, simple preparation process, The effect of facilitating industrial production

Active Publication Date: 2021-11-19
SOUTH CHINA UNIV OF TECH
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this series of products only considers the antibacterial activity, and does not consider the regulation of immune function
[0005] Modification of tea saponin aldehyde group to obtain anti-drug-resistant bacteria and enhance immune function prodrug compounds, the research in this area has not been reported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of tea saponin thiosemicarbazone zinc complex and its preparation method and application
  • A kind of tea saponin thiosemicarbazone zinc complex and its preparation method and application
  • A kind of tea saponin thiosemicarbazone zinc complex and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A preparation method of tea saponin thiosemicarbazone zinc complex, comprising the steps of:

[0036] (1) Theosaponin (C 30 h 48 o 6 ) 10g mixed with 10g thiosemicarbazide, added 100g of absolute ethanol, added 1g of glacial acetic acid, refluxed at 60°C for 10h, and evaporated the solvent under reduced pressure to obtain product 1 (11.5g).

[0037] (2) Dissolve 10 g of product 1 in 100 g of methanol, add 1 g of 0.5% zinc acetate methanol solution, reflux at 50° C. for 10 h, cool to room temperature, filter, and the solid is the final product (11.0 g).

Embodiment 2

[0039] A preparation method of tea saponin thiosemicarbazone zinc complex, comprising the steps of:

[0040] (1) Theosaponin (C 30 h 48 o 6 ) 10g was mixed with 30g of thiosemicarbazide, 300g of absolute ethanol was added, 0.5g of glacial acetic acid was added, refluxed at 90°C for 5h, and the solvent was distilled off under reduced pressure to obtain product 1 (12.6g).

[0041] (2) Dissolve 10 g of product 1 in 300 g of methanol, add 0.5 g of a mass concentration of 5% zinc chloride methanol solution, reflux at 80° C. for 5 h, cool to room temperature, filter, and the solid is the final product (10.5 g) .

Embodiment 3

[0043] A preparation method of tea saponin thiosemicarbazone zinc complex, comprising the steps of:

[0044] (1) Theosaponin (C 30 h 48 o 6 ) 10g mixed with 20g of thiosemicarbazide, added 200g of absolute ethanol, added 0.8g of glacial acetic acid, refluxed at 70°C for 8h, evaporated the solvent under reduced pressure, and obtained product 1 (11.8g).

[0045] (2) Dissolve 10 g of product 1 in 200 g of methanol, add 0.8 g of a mass concentration of 3% zinc sulfate in methanol, reflux at 70° C. for 8 h, cool to room temperature, filter, and the solid is the final product (10.7 g).

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a tea saponin thiosemicarbazone zinc complex, a preparation method and application thereof. The method comprises: mixing tea saponin and thiosemicarbazide, then adding into absolute ethanol, then adding glacial acetic acid, raising the temperature for reflux reaction, removing the solvent, and obtaining product 1; adding product 1 into methanol, and then adding zinc salt The methanol solution was heated up for reflux reaction, cooled to room temperature, and the filter residue was collected by filtration to obtain the tea saponin thiosemicarbazone zinc complex. The invention utilizes the active aldehyde group reaction of tea saponin to obtain a new compound containing sulfide group and amino group, which makes the whole molecule positively charged, and is easy to combine with bacterial cell membrane to realize targeted antibacterial and can be used as anti-drug resistance Bacteria and immune-enhancing pharmaceutical preparations, suitable for humans or livestock and poultry; at the same time, it cooperates with zinc atoms to enhance lipophilicity and improve its immune-enhancing effect. The preparation process of the invention is simple, does not require group protection, has mild conditions, and is convenient for industrialized production.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a tea saponin thiosemicarbazone zinc complex, a preparation method thereof and its application as a medicine for resisting drug-resistant bacteria and enhancing immune function. Background technique [0002] Due to the abuse of antibiotics, more and more drug-resistant bacteria have caused a great threat to human health. In order to solve the above problems, people are working hard to develop alternatives to antibiotics. Tea saponin has antibacterial effect and can reduce the occurrence of drug resistance. [0003] Tea saponin is a hydrolyzed product of tea saponin, which has a smaller molecule and stable structure, and has stronger biological activity than tea saponin. However, the active group in the molecular structure of tea saponin is only hydroxyl, and the interaction with other molecules is weak, resulting in poor selectivity and targeting of drug-resistant bacteria. ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00A61P31/04A61P37/00
CPCA61P31/04A61P37/00C07J63/008
Inventor 叶勇黄传庆刘泽宇
Owner SOUTH CHINA UNIV OF TECH