Desloratadine oral liquid preparation and preparation method thereof

A desloratadine and loratadine technology, applied in the field of desloratadine oral liquid preparation and preparation thereof, can solve problems such as difficulty in preparing oral liquid, achieve good stability and improve bioavailability. Effect

Active Publication Date: 2021-01-15
JIANGSU ALPHA PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For slightly soluble or poorly soluble active pharmaceutical ingredients, it is difficult to prepare oral liquids, and only syrups, dry suspensions or dispersible tablets can be prepared

Method used

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  • Desloratadine oral liquid preparation and preparation method thereof
  • Desloratadine oral liquid preparation and preparation method thereof
  • Desloratadine oral liquid preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Prescription composition:

[0037]

[0038] Preparation process: (1) Add hypromellose to purified water, heat to 70-100°C, stir to dissolve, and cool to room temperature; (2) Add citric acid, sodium citrate, sorbitol and Sucralose and disodium edetate are stirred and dissolved for later use; (3) adding the active ingredient desloratadine and the solubilizer meglumine to propylene glycol, stirring and dissolving, adding to the solution of (2) above, and stirring evenly; (4) Add essence to the above solution and stir evenly; (5) Filter and add purified water to the full amount; (6) Divide.

Embodiment 2

[0040] Prescription composition:

[0041]

[0042] Preparation process: (1) Add hypromellose to purified water, heat to 70-100°C, stir to dissolve, and cool to room temperature; (2) Add citric acid, sodium citrate, sorbitol and Sucralose and disodium edetate are stirred and dissolved for later use; (3) adding the active ingredient desloratadine and the solubilizer meglumine to propylene glycol, stirring and dissolving, adding to the solution of (2) above, and stirring evenly; (4) Add essence to the above solution and stir evenly; (5) Filter and add purified water to the full amount; (6) Divide.

Embodiment 3

[0044] Prescription composition:

[0045]

[0046]

[0047] Preparation process: (1) Add hypromellose to purified water, heat to 70-100°C, stir to dissolve, and cool to room temperature; (2) Add citric acid, sodium citrate, sorbitol and Sucralose, disodium edetate, stirred and dissolved for later use; (3) Add active ingredient desloratadine and solubilizer povidone K30 into propylene glycol, stir and dissolve, add to the above solution of (2), stir evenly (4) Add essence to the above solution and stir evenly; (5) Filter and add purified water to the full amount; (6) Subpackage.

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PUM

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Abstract

The invention belongs to the field of pharmacy, particularly relates to the field of oral liquid preparations, and more particularly relates to a desloratadine oral liquid preparation and a preparation method thereof. The desloratadine oral liquid preparation is an aqueous solution and is composed of a desloratadine active component, a stabilizer, pharmaceutically acceptable auxiliary materials and solvent water. According to the desloratadine oral solution and the preparation method thereof disclosed by the invention, the preparation process is simple, and the patient compliance is good. It can be known through influence factor tests and acceleration tests that products with stable quality can be prepared through the formula technology.

Description

technical field [0001] The invention belongs to the field of pharmacy, in particular to the field of oral liquid preparations, and more specifically relates to desloratadine oral liquid preparations and a preparation method thereof. Background technique [0002] Desloratadine, its chemical name is: 8-chloro-11-(piperidin-4-alkylene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2 -b] pyridine. The structural formula is: [0003] [0004] Desloratadine is a new third-generation antihistamine, a non-sedating long-acting histamine antagonist with selective peripheral H 1 Receptor antagonist activity, after oral administration, desloratadine selectively blocks peripheral histamine H 1 receptors, so the substance does not enter the central nervous system. Desloratadine is used to relieve systemic and local symptoms of chronic urticaria and allergic rhinitis. The drug with desloratadine as the active ingredient has the advantages of fast onset of action, strong efficacy, no cardi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/4545A61K47/10A61K47/18A61K47/32A61K47/26A61K47/38A61P37/08A61P11/02A61P17/00
CPCA61K9/0095A61K31/4545A61K47/10A61K47/183A61K47/32A61K47/26A61K47/38A61P37/08A61P11/02A61P17/00Y02A50/30
Inventor 陈本顺石利平叶金星李大伟张维冰徐春涛程瑞华郭炳华孙伟振孟鑫刘春河何义
Owner JIANGSU ALPHA PHARM CO LTD
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