Milbemycin oxime and praziquantel flavored tablet and preparation method thereof

A technology of mirboxime and praziquantel, which can be applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. and other problems to achieve the effect of improving stability, increasing active feeding rate, and increasing willingness to feed

Pending Publication Date: 2021-01-15
ZHEJIANG HISUN ANIMAL HEALTH PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Based on the above reasons, in order to solve the deficiencies in the prior art, the present invention provides a pet milbexime praziquantel flavor tablet for treating and preventing internal and external parasites, which can not only solve the problem of pet parasites, but also overcome The disadvantage of difficulty in drug administration of commercially available preparations increases the willingness of pets to eat food independently, avoids regurgitation, and facilitates the administration of pet owners

Method used

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  • Milbemycin oxime and praziquantel flavored tablet and preparation method thereof
  • Milbemycin oxime and praziquantel flavored tablet and preparation method thereof
  • Milbemycin oxime and praziquantel flavored tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Tablet prescription:

[0046] Table 1

[0047]

[0048] Coating Solution Prescription:

[0049] Table 2

[0050]

[0051]

[0052] Note: Purified water will be dried during the coating preparation process, and the amount of purified water will not be calculated in the coating prescription.

[0053] Preparation:

[0054] 1) Pass the prescribed amount of milbexime, praziquantel, filler sucrose, and disintegrant croscarmellose sodium through a 50-mesh sieve, and put them into a fluidized bed, and the drugs and auxiliary materials are placed in the lower part of the fluidized bed Under the action of hot air flow at 45°C, mix evenly to obtain a mixture;

[0055] 2) Spray into the mixture in step 1) the adhesive agent 15% povidone aqueous solution of recipe quantity, the powder that has absorbed the solution begins to bond into small particles, along with the continuous adding of adhesive agent povidone aqueous solution, small particle The particles slowly aggre...

Embodiment 2

[0065] Tablet prescription:

[0066] Table 4

[0067]

[0068] Coating Solution Prescription:

[0069] table 5

[0070]

[0071] The preparation method is the same as in Example 1, wherein the weight gain of the coating treatment is 3%.

[0072] Note: Purified water will be dried during the coating preparation process, and the amount of purified water will not be calculated in the coating prescription.

Embodiment 3

[0074] Tablet prescription:

[0075] Table 6

[0076]

[0077]

[0078] Coating Solution Prescription:

[0079] Table 7

[0080]

[0081] Note: Purified water will be dried during the coating preparation process, and the amount of purified water will not be calculated in the coating prescription.

[0082] The preparation method is the same as in Example 1, wherein the weight gain of the coating treatment is 3%.

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PUM

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Abstract

The invention relates to a milbemycin oxime and praziquantel flavored tablet and a preparation method thereof. The milbemycin oxime and praziquantel flavored tablet consists of a tablet core and a drug-free coating layer coating the surface of the tablet core, wherein the coating layer can be one or more layers, and the coating layer contains at least one phagostimulant or flavoring agent; and thetablet core consists of pellets, a flow aid and a lubricant. The preparation process of the milbemycin oxime and praziquantel flavored tablet comprises preparation of drug-containing powder, preparation of the pellets, preparation of the tablet core, preparation of the coating layer and preparation of the flavored tablet. The preparation technology is simple, and the main drug and the auxiliary agent can be uniformly mixed together, so that the auxiliary agent can better play a role, the stability of the drug is improved, the taste of the drug is improved, and the milbemycin oxime and praziquantel flavored tablet is suitable for industrial production and has a wide application prospect.

Description

technical field [0001] The invention relates to the technical field of pet medicines, in particular, the invention relates to a milbexime praziquantel flavored tablet and a preparation method thereof. Background technique [0002] China's pet industry is developing rapidly, and the number of people keeping pets is increasing, and there are more and more pets, among which most of the pets are cats and dogs. Pet cats and dogs are very susceptible to parasites, such as nematodes, roundworms, trematodes, etc., and most parasites can be transmitted to humans. Therefore, it is very important for pets to resist parasites. At present, there are tablets and liquids for external use in the prevention and control of parasites in the market, mainly oral tablets. And most medicines have certain peculiar smell and bitter taste, pet's sense of smell and sense of taste are very sensitive, therefore, the problem that all there is administration difficulty in the oral tablet of pet currently...

Claims

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Application Information

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IPC IPC(8): A61K9/36A61K9/22A61K47/36A61K47/32A61K47/38A61K47/46A61K47/02A61K47/20A61K47/10A61K31/365A61K31/4985A61P33/10A61P33/14
CPCA61K9/2077A61K9/2095A61K9/2059A61K9/2027A61K9/2054A61K9/288A61K9/282A61K9/2813A61K9/2853A61K9/2866A61K9/2893A61K9/2886A61K31/365A61K31/4985A61P33/10A61P33/14A61K2300/00
Inventor 王盈峰谢等龙冀伟王以跃占爱瑶朱齐凤徐红波张华英
Owner ZHEJIANG HISUN ANIMAL HEALTH PROD CO LTD
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